Might uterus transplantation be an option for uterine factor infertility?

Akar, Münire Erman

doi:10.5152/jtgga.2015.15107

Cited by 6 publications

(3 citation statements)

References 32 publications

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“…Uterus transplantation has emerged as a new type of transplant that provides an excellent option for women with lack of a functional womb and a desire to give birth 6 - 9 . One center has already achieved great clinical success with seven transplants 10 and four live births that were successfully reported at the time of writing 9 , 11 .…”

Section: Introductionmentioning

confidence: 99%

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Sheep Model for Uterine Transplantation: The Best Option Before Starting a Human Program

Andraus¹,

Ejzenberg²,

Santos³

et al. 2017

Clinics

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OBJECTIVE:This study reports the first four cases of a uterine transplant procedure conducted in sheep in Latin America. The aim of this study was to evaluate the success of uterine transplantation in sheep.METHOD:The study was conducted at Laboratory of Medical Investigation 37 (LIM 37) at the University of São Paulo School of Medicine. Four healthy mature ewes weighing 40-60 kg were used as both the donor and recipient for a transplant within the same animal (auto-transplant). Institutional guidelines for the care of experimental animals were followed.RESULTS:The first two cases of auto-transplant were performed to standardize the technique. After complete uterine mobilization and isolation of the blood supply, the unilateral vascular pedicle was sectioned and anastomosed on the external iliac vessels. After standardization, the protocol was implemented. Procurement surgery was performed without complications or bleeding. After isolation of uterine arteries and veins as well as full mobilization of the uterus, ligation of the distal portion of the internal iliac vessels was performed with subsequent division and end-to-side anastomosis of the external iliac vessels. After vaginal anastomosis, the final case presented with arterial thrombosis in the left uterine artery. The left uterine artery anastomosis was re-opened and flushed with saline solution to remove the clot from the artery lumen. Anastomosis was repeated with restoration of blood flow for a few minutes before another uterine artery thrombosis appeared on the same side. All four animals were alive after the surgical procedure and were euthanized after the experimental period.CONCLUSION:We describe the success of four uterine auto-transplants in sheep models.

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Section: Introductionmentioning

confidence: 99%

“…Experimental models are very important tools for further study of this transplant modality, and expertise must be acquired for use in clinical procedures 3 , 6 - 8 , 12 . Sheep are predominantly used for this purpose due to their anatomic similarity to women.…”

Section: Introductionmentioning

confidence: 99%

Sheep Model for Uterine Transplantation: The Best Option Before Starting a Human Program

Andraus¹,

Ejzenberg²,

Santos³

et al. 2017

Clinics

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show abstract

“…Since 2014, the revolutionary procedure of uterus allotransplantation (UTx) in humans [9,10] has allowed women with AUFI to partially overcome such complications, introducing the possibility of giving birth to a genetically related child [11]. To date, UTx represents another quality-of-life-type improvement in transplantation, and a milestone in the gynaecological field.…”

Section: Introductionmentioning

confidence: 99%

Uterine transplantation and IVF for congenital or acquired uterine factor infertility: A systematic review of safety and efficacy outcomes in the first 52 recipients

et al. 2020

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Uterine transplantation (UTx) associated with IVF restores fertility in women affected by absolute uterine factor infertility (AUFI). Pregnancies achieved both in women undergoing any solid organ transplantation and following IVF are associated with an increased risk of maternal and neonatal complications. This systematic review evaluated this risk in UTx-IVF treated women focusing on the safety and efficacy features of the treatment. Twenty-two studies and three press releases reporting on 52 UTx-IVF treatments were identified. Regarding the safety of treatment, 38/52 (73,1%) of surgical procedures led to the restoration of uterine function in recipients, 12/52 (23,1%) of recipients experienced post-operative complications requiring hysterectomy, and 2/52 (3,8%) of procedures failed before uterine recipients' surgery due to intra-operative complications. Regarding the efficacy of treatment, results focused on transplanted patients showing full recovery of organ functioning: 16/38 (42,1%) of patients achieved a pregnancy, including two women who gave births twice. UTx-IVF pregnancies led to 16 deliveries and all new-borns were healthy. Six out of 16 (37,5%) UTx pregnancies faced major complications during gestation. Preterm births occurred in 10/16 (62,5%) UTx deliveries. Our data indicates that the risk of gestational and delivery complications deserves important consideration in AUFI women receiving UTx-IVF treatments. However, these observations are preliminary and need to be revised after larger series of data are published.

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A Systematic Review of Tissue Sampling Techniques for the Diagnosis of Adenomyosis

Movilla

Morris

Isaacson

2020

Journal of Minimally Invasive Gynecology

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Might uterus transplantation be an option for uterine factor infertility?

Cited by 6 publications

References 32 publications

Sheep Model for Uterine Transplantation: The Best Option Before Starting a Human Program

Sheep Model for Uterine Transplantation: The Best Option Before Starting a Human Program

Uterine transplantation and IVF for congenital or acquired uterine factor infertility: A systematic review of safety and efficacy outcomes in the first 52 recipients

A Systematic Review of Tissue Sampling Techniques for the Diagnosis of Adenomyosis

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