Achieving uterine auto‐transplantation in a sheep model using iliac vessel anastomosis: a short‐term viability study

Saso, Srdjan; Petts, Gemma; Thum, Meen Yau; Corless, D.; Boyd, Michael; Noakes, D.E.; Priore, Giuseppe Del; Ghaem‐Maghami, Sadaf; Smith, J. R.

doi:10.1111/aogs.12550

Cited by 21 publications

(34 citation statements)

References 19 publications

(29 reference statements)

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“…Each transplant procedure is referred to by a UTx number (rabbits: 3 to 9; sheep: 1 to 5) corresponding to the results described in our surgical papers. 11,12 No imaging was performed in rabbit UTx 1 or 2.…”

Section: Resultsmentioning

confidence: 99%

“…Full details of the surgical procedures may be found in separate papers relating to the sheep 11 and rabbit operations. 12 …”

Section: Materials and Methodologymentioning

confidence: 99%

“…Detailed descriptions of the surgical method and results have been published separately. 11,12 These measurements enable intraoperative quantitative measures of perfusion to be recorded along with spatial information, at different time points in addition to subjective observations. The results of this study help to identify typical trends in organ oxygen saturation that may occur during surgery and recovery, with reference to a baseline.…”

Section: Optical Imaging Of Hemodynamicsmentioning

confidence: 99%

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Multispectral imaging of organ viability during uterine transplantation surgery in rabbits and sheep

et al. 2016

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Abstract. Uterine transplantation surgery (UTx) has been proposed as a treatment for permanent absolute uterine factor infertility (AUFI) in the case of the congenital absence or surgical removal of the uterus. Successful surgical attachment of the organ and its associated vasculature is essential for the organ's reperfusion and long-term viability. Spectral imaging techniques have demonstrated the potential for the measurement of hemodynamics in medical applications. These involve the measurement of reflectance spectra by acquiring images of the tissue in different wavebands. Measures of tissue constituents at each pixel can then be extracted from these spectra through modeling of the light-tissue interaction. A multispectral imaging (MSI) laparoscope was used in sheep and rabbit UTx models to study short-and long-term changes in oxygen saturation following surgery. The whole organ was imaged in the donor and recipient animals in parallel with point measurements from a pulse oximeter. Imaging results confirmed the re-establishment of adequate perfusion in the transplanted organ after surgery. Cornual oxygenation trends measured with MSI are consistent with pulse oximeter readings, showing decreased StO 2 immediately after anastomosis of the blood vessels. Long-term results show recovery of StO 2 to preoperative levels. © The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

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Section: Resultsmentioning

confidence: 99%

“…Full details of the surgical procedures may be found in separate papers relating to the sheep 11 and rabbit operations. 12 …”

Section: Materials and Methodologymentioning

confidence: 99%

Section: Optical Imaging Of Hemodynamicsmentioning

confidence: 99%

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Multispectral imaging of organ viability during uterine transplantation surgery in rabbits and sheep

et al. 2016

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“…Saso et al investigated, developed, and evaluated anatomical, surgical, and anastomotic aspects necessary for a successful uterine transplant in a large animal model [11]. Five auto-transplants were performed in five ewes of proven fertility.…”

Section: Discussionmentioning

confidence: 99%

“…In those, at least two of the four possible anastomoses were finished, and the grafted uteri demonstrated immediate perfusion and appropriate viability 45 min post-operatively. The group concluded that internal to external iliac vessel anastomoses are an acceptable surgical technique that should be applied in a human model to ensure adequate subsequent uterine perfusion [11].…”

Section: Discussionmentioning

confidence: 99%

Human Uterus Transplantation: Have We Opened a Pandora’s Box?

Allahbadia

2015

J Obstet Gynecol India

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Intraoperative multispectral and hyperspectral label‐free imaging: A systematic review of in vivo clinical studies

Shapey

Xie

Nabavi

et al. 2019

Journal of Biophotonics

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Multispectral and hyperspectral imaging (HSI) are emerging optical imaging techniques with the potential to transform the way surgery is performed but it is not clear whether current systems are capable of delivering real-time tissue characterization and surgical guidance. We conducted a systematic review of surgical in vivo label-free multispectral and HSI systems that have been assessed intraoperatively in adult patients, published over a 10-year period to May 2018. We analysed 13 studies including 7 different HSI systems. Current in-vivo HSI systems generate an intraoperative tissue oxygenation map or enable tumour detection. Intraoperative tissue oxygenation measurements may help to predict those patients at risk of postoperative complications and in-vivo intraoperative tissue characterization may be performed with high specificity and sensitivity. All systems utilized a line-scanning or wavelength-scanning method but the spectral range and number of spectral bands employed varied significantly between studies and according to the system's clinical aim. The time to acquire a hyperspectral cube dataset ranged between 5 and 30 seconds. No safety concerns were reported in any studies. A small number of studies have demonstrated the capabilities of intraoperative in-vivo label-free HSI but further work is needed to fully integrate it into the current surgical workflow.

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Achieving uterine auto‐transplantation in a sheep model using iliac vessel anastomosis: a short‐term viability study

Abstract: Internal to external iliac vessel anastomoses are an acceptable surgical technique that should be applied in a human model to ensure adequate subsequent uterine perfusion.

Cited by 21 publications

References 19 publications

Multispectral imaging of organ viability during uterine transplantation surgery in rabbits and sheep

Multispectral imaging of organ viability during uterine transplantation surgery in rabbits and sheep

Human Uterus Transplantation: Have We Opened a Pandora’s Box?

Intraoperative multispectral and hyperspectral label‐free imaging: A systematic review of in vivo clinical studies

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