Modification of polysaccharides: Pharmaceutical and tissue engineering applications with commercial utility (patents)

Malviya, Rishabha; Sharma, Pramod Kumar; Dubey, Susheel Kumar

doi:10.1016/j.msec.2016.06.093

Cited by 48 publications

(20 citation statements)

References 88 publications

(61 reference statements)

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“…In spite of having its own unique properties, NCC are also impaired from poor electrical conductivity which is not practically desired in an electrochemical biosensor. To alleviate its nature property limitations, NCC can be grafted with various foreign monomers through chain reaction to turn NCC into a customizable material [30].…”

Section: Introductionmentioning

confidence: 99%

Reduced Graphene Oxide/TEMPO-Nanocellulose Nanohybrid-Based Electrochemical Biosensor for the Determination ofMycobacterium tuberculosis

et al. 2020

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A novel peptide nuclide acid (PNA) electrochemical biosensor based on reduced graphene oxide (NH2-rGO)/2,2,6,6-tetramethylpiperidin-1-yl)oxyl nanocrystalline cellulose (TEMPO-NCC) for the detection of Mycobacterium tuberculosis (M. Tuberculosis) is described. In this study, the nanohybrid films NH2-rGO/TEMPO-NCC were immobilized onto screen-printed carbon electrode (SPE) via a simple drop-coating method. The electrochemical characterization of the designed electrode was investigated using cyclic voltammetry (CV) and impedance spectroscopy (EIS). Meanwhile, the sensitivity and selectivity of the designed biosensor against M. tuberculosis were measured by the differential pulse voltammetry (DPV). The response of the PNA probe-modified (NH2-rGO)/TEMPO-NCC demonstrated that the fabricated biosensor was able to distinguish between complementary, noncomplementary, and one-base mismatch DNA sequences using methylene blue (MB) as the electrochemical indicator. The developed electrochemical biosensor exhibited a linear calibration curve in the concentration range of 1×10−8 M to 1×10−13 M with the limit of detection of 3.14×10−14 M. The developed electrochemical biosensor has also been tested with a polymerase chain reaction (PCR) product of M. tuberculosis DNA which has shown successful results in distinguishing between negative and positive samples of M. tuberculosis.

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Section: Introductionmentioning

confidence: 99%

Reduced Graphene Oxide/TEMPO-Nanocellulose Nanohybrid-Based Electrochemical Biosensor for the Determination ofMycobacterium tuberculosis

et al. 2020

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“…The responses are classified into chemical and physical categories where multiple responses result in one or more responses or one stimulus results in more than one response. The modified polymer has been used in the application of bone tissue engineering [5]. Stimuli responsive polymers are those polymers that responses with property changes to mall changes in their environment.…”

Section: Introductionmentioning

confidence: 99%

Stimuli-responsive supramolecules for bone tissue engineering

2020

Biointerface Res Appl Chem

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In the recent scenario Stimuli responsive supramolecules are used for bone tissue engineering. Stimuli responsive Supramolecules are responding towards the desired stimuli. This has a property to change their dynamics and undergo impulsive and continual assembly or disassembly processes under specific conditions. These supramolecules respond towards chemical and physical stimuli which include: pH, temperature, light, ionic strength, magnetic and electric field sensitive. Stimuli responsive supramolecules are used to various preparations such as hydrogels, scaffolds, hydrogel scaffolds, 3D bioprinting, 4D bioprinting, nanogels and microgels used for the bone tissue repair and regenerative medicine. Manuscript deals with various approaches used to prepare stimuli responsive supramolecules for bone engineering applications.

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“…Due to hydrophilicity and viscous solution of gums, they may be easily prepared in water and cast to develop films or patches of different dimensions. Grafting is a novel tool to prepare tailored materials with prerequisite properties [10].…”

Section: Introductionmentioning

confidence: 99%

Non-invasive drug delivery system for the delivery of protein/peptide using neem gum and its derivatives

2020

Biointerface Res Appl Chem

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The present investigation is continuation of author’s previous work. In previous work, the author was prepared acrylamide grafted copolymer of neem gum and carboxymethylatedneem gum derivatives. Neem gum polysaccharide (NGP) and its derivatives viz. acrylamide grafted neem gum (NGP-g-Am) and carboxymethylated neem gum (CMNGP) were explored as film forming agent for transdermal delivery of protein/peptide drug (albumin). It was observed that films were not prepared at all the concentrations of NGP with a given concentration range. Studies show that film cannot be prepared using CMNGP even at ahigher concentration of polymer (2 % w/v solution). So only acrylamide grafted neem gum based film were prepared and evaluated. Transdermal films were prepared by using solvent casting method. The developed films were evaluated for various parameters such as drug content, folding endurance, thickness, weight variation, surface pH, moisture uptake, in vitro drug release study and ex-vivo permeation study. The films showed more than 300 folding endurance which demonstrated the good mechanical strength of film. It was also observed that after permeation studies small cracks were also formed in the films. Fabricated films were able to deliver drug upto 7 h. Drug release study and drug permeation studies showed that formulations followed zero order and KorsmeyerPepass model of kinetics. It can be concluded from the findings of the results that acrylamide graft copolymers of neem gum were able to deliver protein/peptide drugs through transdermal route.

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Modification of polysaccharides: Pharmaceutical and tissue engineering applications with commercial utility (patents)

Cited by 48 publications

References 88 publications

Reduced Graphene Oxide/TEMPO-Nanocellulose Nanohybrid-Based Electrochemical Biosensor for the Determination ofMycobacterium tuberculosis

Reduced Graphene Oxide/TEMPO-Nanocellulose Nanohybrid-Based Electrochemical Biosensor for the Determination ofMycobacterium tuberculosis

Stimuli-responsive supramolecules for bone tissue engineering

Non-invasive drug delivery system for the delivery of protein/peptide using neem gum and its derivatives

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