Modification of miRNA Expression through plant extracts and compounds against breast cancer: Mechanism and translational significance

Ahmed, Fayyaz; Ijaz, Bushra; Ahmad, Zarnab; Farooq, Nadia; Sarwar, Muhammad; Husnain, Tayyab

doi:10.1016/j.phymed.2020.153168

Cited by 48 publications

(32 citation statements)

References 166 publications

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“…EGCG can inhibit tumor cell proliferation by regulating mir-16 and miR-21, and can regulate the expression of miRNAs in HepG2 cells. In addition, EGCG can inhibit miR-21 expression in solid tumors such as prostate cancer [28] . EGCG also reduced the expressions of miR-21 and mir-192, increased the level of miR-29a/b/c, and attenuated disease severity in a rat model of cadmium chloride-induced chronic renal injury and brosis [29] .…”

Section: Discussionmentioning

confidence: 99%

WITHDRAWN: Network Pharmacology and Molecular Docking Study of Jinwei Decoction for Enhancement of Glucocorticoid Anti-Inflammatory Effect in COPD through miR-21

Zhang

Chen

et al. 2021

Preprint

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PurposeJinwei decoction can enhance the anti-inflammatory effect of glucocorticoid (GC) on chronic obstructive pulmonary disease (COPD) by restoring the activity of HDAC2. But the upstream mechanism of Jinwei decoction on HDAC2 expression is not clear. ObjectiveTo explore whether Jinwei decoction can enhance the anti-inflammatory effect of GC on COPD through microRNA21 (miR-21) by network pharmacology. MethodsThe TCMSP database was used to screen active ingredients and target genes of Jinwei decoction, and miRWalk2.0 was used to predict downstream target genes of miR-21. COPD-related genes were identified by searching GeneCards and OMIM databases; Venny 2.1 was used to screen intersection genes; Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways of intersection genes were analyzed by R software. Protein-protein interactions (PPIs) were analyzed by Cytoscape 3.7.2 software to identify core genes. Finally, interactions between main compounds and potential targets were verified by molecular docking. ResultsTwo hundred ninety-two active ingredients, 316 Jinwei drug targets, 10170 miR-21 target genes, 6617 COPD target genes, and 184 intersection gene were identified. Eleven core proteins of PPI networks may be involved. GO enrichment analysis showed that oxidative stress, regulation of inflammatory response, hormone transport, and histone modification were involved; KEGG pathway enrichment analysis concentrated in the PI3K-Akt, mitogen-activated protein kinase (MAPK), HIF-1, neutrophil extracellular bactericidal network, and other signaling pathways. ConclusionJinwei decoction can regulate histone deacetylase-2 activity and enhance the anti-inflammatory effect of GC on COPD by modulating miR-21. Its mechanism of action may be related to its effect on the PI3K Akt, MAPK, and TNF signaling pathways and neutrophil extracellular trap formation through miR-21.

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Section: Discussionmentioning

confidence: 99%

WITHDRAWN: Network Pharmacology and Molecular Docking Study of Jinwei Decoction for Enhancement of Glucocorticoid Anti-Inflammatory Effect in COPD through miR-21

Zhang

Chen

et al. 2021

Preprint

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“…Previous studies have indicated that genistein could exert an anti-cancer role in cancers, such as breast cancer, retinoblastoma and laryngeal cancer. 16,17,30 In NSCLC, genistein could facilitate the radiotherapy effect, 31,32 and increase multiple drugs' sensitivity like gefitinib, trichostatin A and cisplatin. [33][34][35] These all suggested the importance of genistein in NSCLC treatment.…”

Section: Discussionmentioning

confidence: 99%

“…The anti-tumor activity of genistein may be associated with the dysregulated noncoding RNAs. 16,17 Circular RNAs (circRNAs) are a group of noncoding RNAs with closed-loop structures, which have important roles in NSCLC progression. 18 Moreover, circRNA/microRNA (miRNA)/mRNA axes are involved in the tumorigenesis, invasion and metastasis of NSCLC.…”

Section: Introductionmentioning

confidence: 99%

Soy isoflavone genistein inhibits hsa_circ_0031250/miR‐873‐5p/FOXM1 axis to suppress non‐small‐cell lung cancer progression

Xing

Zhang

et al. 2020

IUBMB Life

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The foods of plants provide the rich nutrition and have protective function in human diseases, including cancers. Genistein is a major isoflavone constituent in soybeans, which has an anti-cancer role in non-small-cell lung cancer (NSCLC). Nevertheless, the mechanism underlying the anti-cancer function of genistein in NSCLC remains largely unknown. NSCLC cells (H292 and A549) were exposed to genistein. Circular RNA hsa_circ_0031250 (circ_0031250), microRNA (miR)-873-5p and forkhead box M1 (FOXM1) abundances were examined via quantitative reverse transcription polymerase chain reaction and Western blotting. The function of genistein, circ_0031250, miR-873-5p, and FOXM1 on NSCLC progression was investigated via Cell Counting Kit-8, colony formation, transwell well, wound healing, flow cytometry, Western blotting and xenograft model. The target relationship was analyzed by dualluciferase reporter analysis and RNA immunoprecipitation. Results showed that genistein inhibited NSCLC cell viability in dose-time-dependent patterns. circ_0031250 abundance was elevated in NSCLC samples and cell lines, and it was reduced via genistein exposure. circ_0031250 knockdown aggravated genistein-caused suppression of cell proliferation, migration and invasion and elevation of apoptosis. miR-873-5p expression was decreased in NSCLC samples and cells. miR-873-5p was targeted via circ_0031250, and miR-873-5p knockdown attenuated the influence of circ_0031250 silence on NSCLC progression in the presence of genistein. FOXM1 was regulated via circ_0031250/ miR-873-5p axis. miR-873-5p constrained cell proliferation, migration and

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“…Besides single strand interfering RNAs, such as miR MRX34 in a phase I study (NCT01829971), natural compounds have gained attention due to their possible applications in the regulation of miRNAs. Interestingly, these related findings even point out that single compounds are promising drug candidates in that they can regulate multiple miRNAs at the same time [ 22 ]. Thus, this review is aimed at illustrating the function and importance of miRNAs in the EMT process as promising targets in cancer treatment and the collection of compounds with the capacity to suppress EMT via regulating microRNA in cancer.…”

Section: Introductionmentioning

confidence: 99%

MicroRNAs in Epithelial–Mesenchymal Transition Process of Cancer: Potential Targets for Chemotherapy

Peng

Fan

Sui

et al. 2021

IJMS

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In the last decades, a kind of small non-coding RNA molecules, called as microRNAs, has been applied as negative regulators in various types of cancer treatment through down-regulation of their targets. More recent studies exert that microRNAs play a critical role in the EMT process of cancer, promoting or inhibiting EMT progression. Interestingly, accumulating evidence suggests that pure compounds from natural plants could modulate deregulated microRNAs to inhibit EMT, resulting in the inhibition of cancer development. This small essay is on the purpose of demonstrating the significance and function of microRNAs in the EMT process as oncogenes and tumor suppressor genes according to studies mainly conducted in the last four years, providing evidence of efficient target therapy. The review also summarizes the drug candidates with the ability to restrain EMT in cancer through microRNA regulation.

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Modification of miRNA Expression through plant extracts and compounds against breast cancer: Mechanism and translational significance

Cited by 48 publications

References 166 publications

WITHDRAWN: Network Pharmacology and Molecular Docking Study of Jinwei Decoction for Enhancement of Glucocorticoid Anti-Inflammatory Effect in COPD through miR-21

WITHDRAWN: Network Pharmacology and Molecular Docking Study of Jinwei Decoction for Enhancement of Glucocorticoid Anti-Inflammatory Effect in COPD through miR-21

Soy isoflavone genistein inhibits hsa_circ_0031250/miR‐873‐5p/FOXM1 axis to suppress non‐small‐cell lung cancer progression

MicroRNAs in Epithelial–Mesenchymal Transition Process of Cancer: Potential Targets for Chemotherapy

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