2010
DOI: 10.1590/s0004-282x2010000200024
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Modification in body weight associated with antiepileptic drugs

Abstract: Antiepileptic drugs (AED) may cause body weight changes. Objective: To evaluate the dietary habits and body weight associated with AED in epileptic patients. Method: Sixtysix patients were subjected to two interviews, and had their weight and body mass index calculated and compared at both times, interval between six to eight months. Results: It was observed that 59.1% showed weight gain. The patients who had no weight gain had a greater proportion of individuals who engaged in some form of physical activity. … Show more

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Cited by 31 publications
(16 citation statements)
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“…Therapy with valproate (VPA) is often associated with weight gain in adults with epilepsy. 1 Although many studies have examined the magnitude of weight gain, [2][3][4][5][6] relatively few have quantified the distribution of fat in patients taking AEDs. 7 Changes in the distribution of body fat have important health implications, specifically the association of increased relative abdominal fat with risk for cardiovascular disease.…”
mentioning
confidence: 99%
“…Therapy with valproate (VPA) is often associated with weight gain in adults with epilepsy. 1 Although many studies have examined the magnitude of weight gain, [2][3][4][5][6] relatively few have quantified the distribution of fat in patients taking AEDs. 7 Changes in the distribution of body fat have important health implications, specifically the association of increased relative abdominal fat with risk for cardiovascular disease.…”
mentioning
confidence: 99%
“…Epilepsi tedavisi uzun süren bir tedavi oldu¤u için muhtemel yan etkilerin de¤erlendirilmesi ve takibi önemlidir (1). VPA ve KBZ'nin yan etkilerini tart›flan yazarlar genellikle her iki ilac›n da kilo art›fl› yapt›¤› görüflünü savunmakta ve bu ilaçlar kilo art›fl› yapan ilaç-lar olarak kabul edilmektedir (2).…”
Section: Giriflunclassified
“…Benzer flekilde KBZ ile yap›lan çal›flmalarda da %15 ile %25 oran›nda kilo art›fl›na neden oldu¤u sonucuna var›lm›flt›r (7)(8)(9). VPA ve KBZ'nin kilo art›r›c› etkileriyle ilgili bir çok teori ileri sürülmüfl olmakla beraber kilo art›r›c› etki mekanizmalar› tam olarak aç›kl›¤a kavufltu-rulamam›flt›r (1,3,(10)(11)(12)(13). Son y›llarda bu konuda yap›lm›fl olan baz› çal›flmalarda KBZ ve VPA tedavisi sonucunda hastalarda kilo art›fl› izlenmedi¤i belirtilmekte ve bu konuda daha ileri çal›fl-malar›n gerekti¤ine dikkat çekilmektedir (14,15).…”
Section: Giriflunclassified
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