Objective: Long-term treatment with carbamazepine (CBZ) and valproic acid (VPA) is associated with many metabolic changes that influence the serum levels of cholesterol, high-density lipoprotein (HDL), low-density lipoprotein (LDL) and triglycerides and the body mass index (BMI). The aim is to evaluate the serum lipids and BMI in adult epileptic patients on long-term CBZ or VPA monotherapy. Methods: To evaluate the serum lipids and BMI in adult epileptic patients on long-term CBZ or VPA monotherapy. Results: Total cholesterol and LDL levels were significantly higher in patients receiving CBZ, while HDL values were found to be significantly lower in patients receiving VPA. Statistically significant differences were not found between the patient and control groups in terms of BMI. Conclusion: These data suggest that long-term VPA treatment significantly correlated with decreased HDL levels, while CBZ treatment significantly correlated with elevation in the values of total cholesterol and LDL. Long-term CBZ or VPA treatment do not seem to affect the BMI. (Archives of Neuropsychiatry 2011; 48: 103-6) Key words: Epilepsy, antiepileptic treatment, body mass index, lipid profile ÖZET Amaç: Uzun süreli karbamazepin (KBZ) ve valproik asit (VPA) tedavisi total kolesterol, düflük-yüksek dansiteli lipoprotein, trigliserit ve vücut kitle indeksini etkileyen birçok metabolik de¤iflikli¤e yol açabilir. Uzun süreli VPA ve KBZ monoterapisi alm›fl olan yetiflkin hastalarda serum lipidleri ve vücut kitle indeksini de¤erlendirmek, amaçlanm›flt›r. Yöntemler: Karbamazepin (n=36) ve valproik asit (n=53) kullanan 89 epileptik hastada total kolesterol, düflük-yüksek dansiteli lipoprotein, trigliserit ve vücut kitle indeksleri ölçüldü. De¤erler kontrol (22) grubu ile karfl›laflt›r›ld›. Bulgular: KBZ alan grupta total kolesterol ve düflük dansiteli lipoprotein anlaml› düzeyde kontrol grubundan yüksek bulundu. VPA alan grupta yüksek dansiteli lipoprotein anlaml› düzeyde kontrol grubundan düflük bulundu. Hasta gruplar› ve kontrol grubu aras›nda vücut kitle indeksi aç›s›ndan istatistiksel olarak anlaml› bir sonuç saptanmad›. Sonuç: Bu sonuçlar uzun süreli VPA tedavisinin serum yüksek dansiteli lipoprotein düzeyinde anlaml› bir düflüklük ile, KBZ tedavisinin ise düflük dansiteli lipoprotein ve total kolesterol yüksekli¤i ile beraber oldu¤unu göstermektedir. Uzun süreli VPA ve KBZ tedavisi vücut kitle indeksini etkilemiyor gibi görünmektedir. (Nöropsikiyatri Arflivi 2011; 48: 103-6)
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