Modes development of PLGA scaffolds modification by magnetron co-sputtering of Cu and Ti targets

Badaraev, Arsalan D.; Sidelev, Dmitrii V.; Yurjev, Y N; Bukal, V. R.; Tverdokhlebov, Sergei I.

doi:10.1088/1742-6596/1799/1/012001

Cited by 5 publications

(3 citation statements)

References 10 publications

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“…Polymer scaffolds were modified by titanium (Ti-modified) using an ion-plasma setup equipped with a magnetron sputtering system [32]. For this modification, an APEL-M-5PDC power supply (Applied Electronics, Tomsk, Russia) working in unipolar mode (according to the reference [33]) with a frequency of 100 kHz and a duty cycle of 70% was connected to a magnetron with a titanium (99.95%) target. The polymer scaffolds were modified under the following parameters: discharge power: 750 W, voltage: 500 V, current: 1.5 A, modification time: 35 min, working pressure in the chamber: 0.3 Pa, working gas: argon (Ar, 99.99%), target shape: a disk with a diameter of 90 mm and a thickness of 8 mm.…”

Section: Surface Modification Proceduresmentioning

confidence: 99%

Surface Modification of Electrospun Bioresorbable and Biostable Scaffolds by Pulsed DC Magnetron Sputtering of Titanium for Gingival Tissue Regeneration

et al. 2022

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In this study, polymer scaffolds were fabricated from biodegradable poly(lactide-co-glycolide) (PLGA) and from non-biodegradable vinylidene fluoride-tetrafluoroethylene (VDF-TeFE) by electrospinning. These polymer scaffolds were subsequently surface-modified by sputtering titanium targets in an argon atmosphere. Direct current pulsed magnetron sputtering was applied to prevent a significant influence of discharge plasma on the morphology and mechanical properties of the nonwoven polymer scaffolds. The scaffolds with initially hydrophobic properties show higher hydrophilicity and absorbing properties after surface modification with titanium. The surface modification by titanium significantly increases the cell adhesion of both the biodegradable and the non-biodegradable scaffolds. Immunocytochemistry investigations of human gingival fibroblast cells on the surface-modified scaffolds indicate that a PLGA scaffold exhibits higher cell adhesion than a VDF-TeFE scaffold.

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Section: Surface Modification Proceduresmentioning

confidence: 99%

Surface Modification of Electrospun Bioresorbable and Biostable Scaffolds by Pulsed DC Magnetron Sputtering of Titanium for Gingival Tissue Regeneration

et al. 2022

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“…The targets had a disk-like shape with a diameter of 90 mm and a thickness of 8 mm. Two separate power supplies (APEL-M-5PDC, Applied Electronics, Tomsk, Russia) were used to power the first magnetron with the copper target and the second magnetron with the titanium target operating in a unipolar mode (according to reference [ 49 ]) with a pulse frequency of 100 kHz and a duty cycle of 70%.…”

Section: Methodsmentioning

confidence: 99%

Antibacterial Activity and Cytocompatibility of Electrospun PLGA Scaffolds Surface-Modified by Pulsed DC Magnetron Co-Sputtering of Copper and Titanium

et al. 2023

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Biocompatible poly(lactide-co-glycolide) scaffolds fabricated via electrospinning are having promising properties as implants for the regeneration of fast-growing tissues, which are able to degrade in the body. The hereby-presented research work investigates the surface modification of these scaffolds in order to improve antibacterial properties of this type of scaffolds, as it can increase their application possibilities in medicine. Therefore, the scaffolds were surface-modified by means of pulsed direct current magnetron co-sputtering of copper and titanium targets in an inert atmosphere of argon. In order to obtain different amounts of copper and titanium in the resulting coatings, three different surface-modified scaffold samples were produced by changing the magnetron sputtering process parameters. The success of the antibacterial properties’ improvement was tested with the methicillin-resistant bacterium Staphylococcus aureus. In addition, the resulting cell toxicity of the surface modification by copper and titanium was examined using mouse embryonic and human gingival fibroblasts. As a result, the scaffold samples surface-modified with the highest copper to titanium ratio show the best antibacterial properties and no toxicity against mouse fibroblasts, but have a toxic effect to human gingival fibroblasts. The scaffold samples with the lowest copper to titanium ratio display no antibacterial effect and toxicity. The optimal poly(lactide-co-glycolide) scaffold sample is surface-modified with a medium ratio of copper and titanium that has antibacterial properties and is non-toxic to both cell cultures.

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“…Many biocompatible polymers are used in medical implants with some demonstrating high biocompatibility [25]. The most commonly used biocompatible polymers are polyglycolic acid (PGA) [26,27], poly(lactic-co-glycolic acid) (PLGA) [26,[28][29][30], polycaprolactone (PCL) [26,31,32], polyurethane (PU) [33], polyvinyl alcohol (PVA) [34][35][36], silicone [33,37,38], polylactic acid (PLA) [26,[39][40][41][42][43][44], polypropylene (PP) [45,46], and polymethyl methacrylate (PMMA) [47][48][49]. Each polymer has distinct advantages and limitations in various biomedical applications, as mentioned in Table 1.…”

Section: Polymers Used In Biomedical Applicationsmentioning

confidence: 99%

Progress in Nanostructured Mechano-Bactericidal Polymeric Surfaces for Biomedical Applications

Kumara,

Senevirathne,

Mathew

et al. 2023

Nanomaterials

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Bacterial infections and antibiotic resistance remain significant contributors to morbidity and mortality worldwide. Despite recent advances in biomedical research, a substantial number of medical devices and implants continue to be plagued by bacterial colonisation, resulting in severe consequences, including fatalities. The development of nanostructured surfaces with mechano-bactericidal properties has emerged as a promising solution to this problem. These surfaces employ a mechanical rupturing mechanism to lyse bacterial cells, effectively halting subsequent biofilm formation on various materials and, ultimately, thwarting bacterial infections. This review delves into the prevailing research progress within the realm of nanostructured mechano-bactericidal polymeric surfaces. It also investigates the diverse fabrication methods for developing nanostructured polymeric surfaces with mechano-bactericidal properties. We then discuss the significant challenges associated with each approach and identify research gaps that warrant exploration in future studies, emphasizing the potential for polymeric implants to leverage their distinct physical, chemical, and mechanical properties over traditional materials like metals.

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Modes development of PLGA scaffolds modification by magnetron co-sputtering of Cu and Ti targets

Cited by 5 publications

References 10 publications

Surface Modification of Electrospun Bioresorbable and Biostable Scaffolds by Pulsed DC Magnetron Sputtering of Titanium for Gingival Tissue Regeneration

Surface Modification of Electrospun Bioresorbable and Biostable Scaffolds by Pulsed DC Magnetron Sputtering of Titanium for Gingival Tissue Regeneration

Antibacterial Activity and Cytocompatibility of Electrospun PLGA Scaffolds Surface-Modified by Pulsed DC Magnetron Co-Sputtering of Copper and Titanium

Progress in Nanostructured Mechano-Bactericidal Polymeric Surfaces for Biomedical Applications

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