Surface Modification of Electrospun Bioresorbable and Biostable Scaffolds by Pulsed DC Magnetron Sputtering of Titanium for Gingival Tissue Regeneration

Badaraev, Arsalan D.; Sidelev, Dmitrii V.; Kozelskaya, Anna; Bolbasov, E. N.; Tran, Tuan‐Hoang; Nashchekin, A. V.; Malashicheva, Anna; Rutkowski, Sven; Tverdokhlebov, Sergei I.

doi:10.3390/polym14224922

Cited by 7 publications

(19 citation statements)

References 71 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Viable L-929 and MG-63 cells stained green were observed throughout the membrane, showing significant cell proliferation over more than 24 h of culture. It proliferated continuously over time, suggesting that it is suitable for applications in membranes for tissue and bone regeneration [8,30,31]. The PLLA/gelatin…”

Section: Cell Viability and Proliferationmentioning

confidence: 99%

Electrospun Poly(L-Lactic Acid)/Gelatin Hybrid Polymer as a Barrier to Periodontal Tissue Regeneration

Cho,

Jeong,

Kim

et al. 2023

Polymers

View full text Add to dashboard Cite

Poly(L-lactic acid) (PLLA) and PLLA/gelatin polymers were prepared via electrospinning to evaluate the effect of PLLA and gelatin content on the mechanical properties, water uptake capacity (WUC), water contact angle (WCA), degradation rate, cytotoxicity and cell proliferation of membranes. As the PLLA concentration increased from 1 wt% to 3 wt%, the tensile strength increased from 5.8 MPa to 9.1 MPa but decreased to 7.0 MPa with 4 wt% PLLA doping. The WUC decreased rapidly from 594% to 236% as the PLLA content increased from 1 to 4 wt% due to the increased hydrophobicity of PLLA. As the gelatin content was increased to 3 wt% PLLA, the strength, WUC and WCA of the PLLA/gelatin membrane changed from 9.1 ± 0.9 MPa to 13.3 ± 2.3 MPa, from 329% to 1248% and from 127 ± 1.2° to 0°, respectively, with increasing gelatin content from 0 to 40 wt%. However, the failure strain decreased from 3.0 to 0.5. The biodegradability of the PLLA/gelatin blend increased from 3 to 38% as the gelatin content increased to 40 wt%. The viability of L-929 and MG-63 cells in the PLLA/gelatin blend was over 95%, and the excellent cell proliferation and mechanical properties suggested that the tunable PLLA/gelatin barrier membrane was well suited for absorbable periodontal tissue regeneration.

show abstract

Section: Cell Viability and Proliferationmentioning

confidence: 99%

Electrospun Poly(L-Lactic Acid)/Gelatin Hybrid Polymer as a Barrier to Periodontal Tissue Regeneration

Cho,

Jeong,

Kim

et al. 2023

Polymers

View full text Add to dashboard Cite

show abstract

“…The Raman spectra of unmodified PLGA scaffolds did not show peaks because the metal coating on the fibers can easily reflect the light, which significantly reduces the signal intensity. In addition, the absence of polymer peaks in the Raman spectra and the significant change in the intensity of C1s peaks in the XPS spectra of the surface-modified PLGA scaffolds might be related to carbon contamination [ 62 ]. According to reference [ 62 ], after argon ion beam etching of surface-modified PLGA scaffolds, the intensity of C1s spectra decreased and the intensity of Ti2p and O1s spectra increased.…”

Section: Resultsmentioning

confidence: 99%

“…In addition, the absence of polymer peaks in the Raman spectra and the significant change in the intensity of C1s peaks in the XPS spectra of the surface-modified PLGA scaffolds might be related to carbon contamination [ 62 ]. According to reference [ 62 ], after argon ion beam etching of surface-modified PLGA scaffolds, the intensity of C1s spectra decreased and the intensity of Ti2p and O1s spectra increased. This indicates the formation of impurities on the surface of the framework after modification by magnetron sputtering.…”

Section: Resultsmentioning

confidence: 99%

Antibacterial Activity and Cytocompatibility of Electrospun PLGA Scaffolds Surface-Modified by Pulsed DC Magnetron Co-Sputtering of Copper and Titanium

et al. 2023

Self Cite

View full text Add to dashboard Cite

Biocompatible poly(lactide-co-glycolide) scaffolds fabricated via electrospinning are having promising properties as implants for the regeneration of fast-growing tissues, which are able to degrade in the body. The hereby-presented research work investigates the surface modification of these scaffolds in order to improve antibacterial properties of this type of scaffolds, as it can increase their application possibilities in medicine. Therefore, the scaffolds were surface-modified by means of pulsed direct current magnetron co-sputtering of copper and titanium targets in an inert atmosphere of argon. In order to obtain different amounts of copper and titanium in the resulting coatings, three different surface-modified scaffold samples were produced by changing the magnetron sputtering process parameters. The success of the antibacterial properties’ improvement was tested with the methicillin-resistant bacterium Staphylococcus aureus. In addition, the resulting cell toxicity of the surface modification by copper and titanium was examined using mouse embryonic and human gingival fibroblasts. As a result, the scaffold samples surface-modified with the highest copper to titanium ratio show the best antibacterial properties and no toxicity against mouse fibroblasts, but have a toxic effect to human gingival fibroblasts. The scaffold samples with the lowest copper to titanium ratio display no antibacterial effect and toxicity. The optimal poly(lactide-co-glycolide) scaffold sample is surface-modified with a medium ratio of copper and titanium that has antibacterial properties and is non-toxic to both cell cultures.

show abstract

“…Over the past few decades, these thin films have undergone extensive study, and numerous efforts have been made to broaden their application fields to include areas such as oil hydrophobicity [ 11 , 12 ], hydrophobic anti-icing [ 13 ], and hydrophobic anti-corrosion [ 14 , 15 ]. Additionally, fresh studies that explore approximate theories and fabrication techniques for hydrophobic thin films have emerged [ 16 , 17 , 18 , 19 ].…”

Section: Introductionmentioning

confidence: 99%

“…However, these techniques differ in terms of their efficiency, cost, simplicity of use, and requirements for specialized reagents. Some techniques are also Materials 2023, 16, 3764 2 of 22 restricted to basic laboratory experiments, and much work still needs to be performed to prepare hydrophobic films on a commercial scale. Therefore, researchers are working to make these films easier to prepare, cheaper, more durable, and more functional.…”

Section: Introductionmentioning

confidence: 99%

Review on Hydrophobic Thin Films Prepared Using Magnetron Sputtering Deposition

et al. 2023

Materials

View full text Add to dashboard Cite

Hydrophobic thin films have gained significant attention due to their broad applications in self-cleaning, anti-corrosion, anti-icing, medicine, oil–water separation, and other fields. The target hydrophobic materials can be deposited onto various surfaces thanks to the scalable and highly reproducible nature of magnetron sputtering, which is comprehensively overviewed in this review. While alternative preparation methods have been extensively analyzed, a systematic understanding of hydrophobic thin films fabricated using magnetron sputtering deposition is still absent. After outlining the fundamental mechanism of hydrophobicity, this review briefly summarizes three types of sputtering-deposited thin films that originate from oxides, polytetrafluoroethylene (PTFE), and diamond-like carbon (DLC), respectively, primarily focusing on the recent advances in their preparation, characteristics, and applications. Finally, the future applications, current challenges, and development of hydrophobic thin films are discussed, and a brief perspective on future research directions is provided.

show abstract

Surface Modification of Electrospun Bioresorbable and Biostable Scaffolds by Pulsed DC Magnetron Sputtering of Titanium for Gingival Tissue Regeneration

Cited by 7 publications

References 71 publications

Electrospun Poly(L-Lactic Acid)/Gelatin Hybrid Polymer as a Barrier to Periodontal Tissue Regeneration

Electrospun Poly(L-Lactic Acid)/Gelatin Hybrid Polymer as a Barrier to Periodontal Tissue Regeneration

Antibacterial Activity and Cytocompatibility of Electrospun PLGA Scaffolds Surface-Modified by Pulsed DC Magnetron Co-Sputtering of Copper and Titanium

Review on Hydrophobic Thin Films Prepared Using Magnetron Sputtering Deposition

Contact Info

Product

Resources

About