Modern Potential in the Treatment of Metabolic Syndrome Patients - Focus on Endothelium

Мычка, В. Б.; Tolstov, S. N.; Салов, И. А.; Прохорова, Ю. В.; Узуева, Э. И.; Верткин, А. Л.

doi:10.15829/1560-4071-2014-3-107-113

Cited by 3 publications

(3 citation statements)

References 11 publications

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“…Elevated uric acid (UA) as a predictor of cardiovascular morbidity and mortality has been studied in virtually every large population-based study, with varying results. An independent relationship has been established between the level of uric acid, morbidity and mortality from cardiovascular pathology, as well as the risk of developing coronary diseases and the frequency of hospitalizations [1][2][3][4][5][6][7][8]. However, the results of a large number of epidemiological and clinical studies aimed at detecting the pathogenetic relationship of HU, arterial hypertension, and other risk factors are contradictory [2,4,5].…”

Section: Introductionmentioning

confidence: 99%

Hyperuricemia as a risk factor for arterial hypertension among the population of the Fergana region of the Republic of Uzbekistan

Sadikov,

Bobojonov,

Yusupova

et al. 2023

BIO Web Conf.

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Today, a lot of data has been accumulated on the role of purine metabolism disorders in the development of a number of diseases, including cardiovascular diseases. However, the results of a large number of epidemiological and clinical studies aimed at detecting the pathogenetic relationship between hyperuricemia (HU) and arterial hypertension (AH) are contradictory. According to the purpose of the study - to study the epidemiological conditions in relation to hypertension in connection with HU and other risk factors in order to be ¬able to plan multifactorial prevention on this basis, we carried out epidemiological study ¬of hypertension due to a combination of risk factors such as HU, impaired carbohydrate tolerance (IHT), pesticideemia, dyslipoproteinemia (DLP), overweight and smoking among rural men ¬and women of working age. We chose a continuous method of epidemiological examination with the measurement of blood pressure, ECG, anthropometric and biochemical studies. To determine the groups for primary, secondary and tertiary prevention, we have established the level of individual risk of developing hypertension. On this basis, a percentile distribution was built and the entire population of men and women was divided into 3 groups: 1-group of moderate risk (84.6%); 2-high-risk group (10.3%) and 3-group of patients (5.1%).

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Section: Introductionmentioning

confidence: 99%

Hyperuricemia as a risk factor for arterial hypertension among the population of the Fergana region of the Republic of Uzbekistan

Sadikov,

Bobojonov,

Yusupova

et al. 2023

BIO Web Conf.

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“…Интересно, что наиболее широкий взгляд на МС, метаболическое нездоровье появился в 2013г в российском консенсусном документе [10]. И хотя в нем были предложены достаточно традиционные для 2013г критерии МС, определение МС было предложено очень прогрессивное, в котором указывалось, что "МС характеризуется увеличением объема висцерального жира и снижением чувствительности периферических тканей к инсулину, которые вызывают развитие нарушений углеводного, липидного, пуринового обменов, артериальной гипертонии, атеросклероза, заболеваний печени, почек, репродуктивной системы, онкопатологии, что повышает риск сердечно-сосудистой и общей смертности".…”

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“…Мы в своей публикации 2013г также подчеркивали, что МС понимается слишком узко и что он требует более глубокого изучения этиопатогенетической основы МС и необходимости обязательным его элементом всегда считать именно висцеральное ожирение, диагностируемое на основании ПЕРЕДОВАЯ СТАТЬЯ превышения пороговой величины ОТ [9]. Более того, в консенсусном документе 2013г российскими экспертами определена возможность альтернативной оценки наличия висцерального ожирения на основании пороговых величин эхокардиографически определяемой толщины эпикардиального жира [10]. А уже позже, в 2023г Российским обществом профилактики неинфекционных заболеваний под руководством О. М. Драпкиной были опубликованы методические рекомендации, регламентирующие порядок организации и методику проведения ультразвукассистированной оценки ВЖТ и предлагающие алгоритм диагностики висцерального ожирения [11].…”

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Metabolic health of the population: a modern view of the problem and solutions

Chumakova,

Kuznetsova,

Druzhilov

et al. 2024

Russ J Cardiol

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Studying the metabolic health of population around the world is becoming a priority area of modern medicine. This is associated with an increase in the prevalence of overweight and obesity, which leads to a significant increase in related metabolic diseases, which are actually complications of obesity, primarily visceral. According to 2019 data, overweight and obesity are associated with 5 million deaths and 160 million disability-adjusted life years, more than half of which are due to cardiovascular diseases. This challenge requires the development of cardiometabolic medicine and the training of new specialists.

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Polymorphic variants of ACE, AGT, AGTR1, MTHFR and NOS3 candidate genes connected with arterial hypertension as part of the metabolic syndrome among the shor people

2021

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Background: The problem of high blood pressure in the framework of metabolic syndrome (MS) is one of the most important for modern medicine in connection with the predicted increase in the incidence in the future and an increase in the mortality rate from cardiovascular disease.Aims: the aim of the study is to examine the frequency of arterial hypertension (AH) as part of the MS among the members of the indigenous population of the Mountain Shoria and to state the degree of the interconnection between the expression level of the candidate genes ACE, AGT, AGTR1, MTHFR and NOS3 and certain health problem.Materials and methods: The sample included 901 members of the indigenous population living in the settlements of the Mountain Shoria region. All experimental subjects had their blood pressure measured, anthropometry (measurements of height, body weight, waist circumference) taken according to standard procedures, fasting blood taken to determine the lipid spectrum and glucose level, morning urine dose taken and albumin level detected. All the patients with hypertension underwent duplex scanning of the brachycephalic arteries and examination of the structural and functional state of the myocardium was performed using echocardiography. Gene polymorphisms ACE (I/D, rs4340), AGT (c.803T>C, rs699), AGTR1 (A1166C, rs5186), MTHFR (c.677C>T, Ala222Val, rs1801133) and NOS3 (VNTR, 4b/4a) were tested using polymerase chain reaction.Results: Among the indigenous population of the Mountain Shoria, the frequency of hypertension combined with abdominal obesity and any other additional component of MS was 28.2%. In the group of the patients with, organ changes in the form of left ventricular myocardial hypertrophy and an increase in the thickness of the intima-media complex were more common than in the group of patients with AH alone: 58.0% versus 45.1%, p = 0.029 and 81.9% versus 67 , 0%, p = 0.007, respectively. The high risk of hypertension within the framework of MS was determined by the D allel of the ACE gene [OR = 2.45; 95% CI (1.05-5.72)].Conclusions: The high frequency of the spread of high blood pressure within MS confirms that hypertension is less frequently manifested as an isolated disease, more often combined with other components of MS — abdominal obesity or disorders of carbohydrate and lipid metabolism. Stated genetic predisposition to hypertension within the MS in a specific small cohort of the Shors will undoubtedly help in the development and implementation of the health programs.

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Modern Potential in the Treatment of Metabolic Syndrome Patients - Focus on Endothelium

Cited by 3 publications

References 11 publications

Hyperuricemia as a risk factor for arterial hypertension among the population of the Fergana region of the Republic of Uzbekistan

Hyperuricemia as a risk factor for arterial hypertension among the population of the Fergana region of the Republic of Uzbekistan

Metabolic health of the population: a modern view of the problem and solutions

Polymorphic variants of ACE, AGT, AGTR1, MTHFR and NOS3 candidate genes connected with arterial hypertension as part of the metabolic syndrome among the shor people

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