Modern Management of Mild-to-Moderate Joint Pain due to Osteoarthritis: A Holistic Approach

Abstract

Osteoarthritis (OA) is the most common form of arthritis and it is often associated with significant disability and impaired quality of life. Once thought to be caused by an age-related 'wearing out' of articular cartilage, it is now recognized to be a dynamic process in which cartilage degradation alternates with repair. Several expert guidelines for the management of OA exist, which concur in their recommendations for a stepwise approach to the employment of pharmacological agents and the introduction of suggestions to extend the use of agents such as topical nonsteroidal anti-inflammatory drugs, especially for mild-to-moderate forms of the disease. They also emphasize the importance of non-pharmacological measures, such as nutraceuticals, education, diet, exercise and the use of aids in improving signs and symptoms and slowing progression. In many countries, effective medicinal and nutraceutical agents are available 'overthe-counter'. This review explains the modern approach to the management of mild-to-moderate osteoarthritic pain.

Pooled safety analysis of diclofenac sodium topical solution 1.5% (w/w) in the treatment of osteoarthritis in patients aged 75 years or older

“…Multimodal treatment strategies are frequently employed; these approaches generally incorporate weight management and exercise programs, physical and occupational therapy, and other types of nonpharmacologic and nonsurgical therapies 8,9. Total joint arthroplasty is employed as a definitive treatment in advanced disease; total hip and knee replacements are the most common procedures 2.…”

Evaluación de la eficacia y seguridad del ácido hialurónico por vía oral asociado con glucosamina sulfato, condroitín sulfato y metilsulfonilmetano comparado con la asociación por vía oral de glucosamina sulfato, condroitín sulfato ymetilsulfonilmetano en la osteoartritis de rodilla

“…Se realizó un ensayo clínico, doble ciego, aleatorizado para evaluar la eficacia y la seguridad en dos grupos paralelos en personas mayores de 40 años y menores de 80 años con diagnóstico de OA de rodilla o de cadera ,que tuvieran dolor de rodilla o de cadera de por lo menos tres meses de duración, con una puntuación del WOMAC para dolor entre 12 y 16, que corresponde a dolor moderado o grave, y que tuvieran una imagen radiográfica de grado II a III de Kelgren-Lawrence, de acuerdo a los criterios modificados del ACR. 14 El ensayo clínico se realizó en los servicios de Reumatología y Traumatología de la Clínica Anglo Americana, Lima, Perú, de noviembre de 2011 a febrero de 2014.…”

miR‑335‑5P contributes to human osteoarthritis by targeting HBP1

“…Osteoarthritis (OA) is a type of disease in which articular cartilage becomes fibrotic and ulcerated and can be lost (1). The common clinical manifestations of OA are joint pain and tenderness, joint stiffness, joint swelling, bone friction and joint weakness (2). In general, OA can be pathologically summarized as cartilage degeneration and synovitis, and its main features are the degradation of articular cartilage tissue and the apoptosis of chondrocytes (3).…”