“…22,26 The relationship between CHD and GP can be explained by the activation of the free-radical lipid oxidation (FRLO) processes and the imbalance in the antioxidant protection system, which underlie the pathogenesis of most diseases. 22,27 In patients under study, activation of FRLO processes is probably a result of chronic hypoxia, which is a result of microcirculation disorders, 22,28 activation of pro-inflammatory cytokines, and other inflammatory mediators, including ADMA, 21 galectin-3 18 , NLPR3 and IL-1β. 20 In its turn, oxidative stress causes activation of the remodulation processes of target organs.…”