Modelling of the supercritical fluid extraction of monocrotaline from Crotalaria Spectabilis

Schaeffer, Steven T.; Zalkow, Leon H.; Teja, Amyn S.

doi:10.1016/0896-8446(89)90005-3

Cited by 16 publications

(6 citation statements)

References 5 publications

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“…and Senecio cordatus Koch ex Senecio alpinus L. (10)] was investigated and compared to the classical Soxhlet extraction method. Sfe has already been applied to PA extraction by Schaeffer et al (11)(12)(13), who investigated in depth the extraction of monocrotaline from the seeds of Crotalaria spectabilis.…”

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confidence: 99%

Off-line Supercritical Fluid Extraction and Capillary Gas Chromatography of Pyrrolizidine Alkaloids in Senecio Species

Bicchi¹,

Rubiolo²,

Frattini³

et al. 1991

J. Nat. Prod.

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The pyrrolizidine alkaloid (PA) fraction of two Senecio species (Senecio inaequidenr and Senerio cordatus) was extracted by off-line supercritical fluid extraction (sfe) and analyzed by capillary gas chromatography. Sfe was carried out with a home-assembled apparatus, using MeOH/CO, as extraction medium, at 55" and 15 MPa. Compared to the classical MeOH Soxhlet extraction, this technique requires a smaller sample amount and provides a quicker extraction, a simplified PA fraction clean-up, and a higher recovery.Supercritical fluid extraction (sfe) is a very powerful method for the extraction oforganic compounds from solid matrices, e.g., flavors and fragrances from natural products, toxic organics from resins, polycyclic aromatic hydrocarbons and polychlorinated biphenyls from environmental solids, etc. The supercritical fluid most often applied is CO, because of its low critical temperature ( 3 lo) and pressure (7.3 MPa). Sfe therefore can be performed at relatively low temperatures, avoiding decomposition of thermolabile compounds. Sfe can be coupled either on-line or off-line with capillary gas chromatography (gc) (1-3). Several sfe systems have been described: Sandra, Onuska, and co-workers proposed an effective and easy-to-assemble apparatus for off-line sfe/ capillary gc (4-6).Pyrrolizidine alkaloids (PAS) with known hepatotoxic and allelopathic properties (7-9) occur in several worldwide plant families, e.g., Boraginaceae, Compositae (Senecioneae and Eupatorieae tribes), and Leguminosae (genus Crotalaria).The applicability of off-line sfe/capillary gc for the analysis of the PA fraction in plants of the Senecio genus [in particular Senecio inaequikns DC. and Senecio corhtus Koch ex Senecio alpinus L. (lo)] was investigated and compared to the classical Soxhlet extraction method. Sfe has already been applied to PA extraction by Schaeffer etal. (1 1-13), who investigated in depth the extraction of monocrotaline from the seeds of Crotalaria spectabilis. RESULTS AND DISCUSSIONPAS are classically extracted from a vegetable matrix by MeOH Soxhlet extraction.This operation is relatively time-consuming (4 h) and requires large amounts of solvent and plant material. Sfe can provide very rapid extraction with high recovery using very small sample amounts. Various densities of supercritical CO, were first tried for the extraction of PAS; this was unsuccessful, probably due to the inappropriate polarity or solvent strength of CO,. Polarity can be increased by adding a modifier. MeOH was chosen for two reasons: it is the usual extraction solvent for PAS, and it is one of the most effective polarity modifiers for supercritical CO,, since amounts as high as 20% are miscible with co*.

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confidence: 99%

Off-line Supercritical Fluid Extraction and Capillary Gas Chromatography of Pyrrolizidine Alkaloids in Senecio Species

Bicchi¹,

Rubiolo²,

Frattini³

et al. 1991

J. Nat. Prod.

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“…Algerian Rosmarinus eriocalyx was submitted to supercritical carbon dioxide extraction to obtain its antioxidant components [66]. Monocrotaline was extracted from Crotalaria spectabilis seeds by means of supercritical carbon dioxide with an ethanol co-solvent and the process was modelled in Reference [67].…”

Section: Supercritical Fluid Extraction From Bio-materialsmentioning

confidence: 99%

Some Advances in Supercritical Fluid Extraction for Fuels, Bio-Materials and Purification

Marcus

2019

Processes

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Supercritical fluids are used for the extraction of desired ingredients from natural materials, but also for the removal of undesired and harmful ingredients. In this paper, the pertinent physical and chemical properties of supercritical water, methanol, ethanol, carbon dioxide, and their mixtures are provided. The methodologies used with supercritical fluid extraction are briefly dealt with. Advances in the application of supercritical extraction to fuels, the gaining of antioxidants and other useful items from biomass, the removal of undesired ingredients or contaminants, and the preparation of nanosized particles of drugs are described.

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“…A combined thermodynamic/mass transfer model is reported in the literature that applied a mathematical relationship based on the unsteady-state extraction of monocrotaline and lipids from Crotalaria spectabilis with supercritical CO 2 and an ethanol entrainer in a fixed-bed extractor (22). Another similar model that described the extraction of oil from soybean flakes (23) was also applied to dried algae (7) and fungi (8).…”

Section: Theory and Model Developmentmentioning

confidence: 99%

Supercritical carbon dioxide extraction of lipids from Pythium irregulare

Walker

Cochran

Hulbert

1999

J Americ Oil Chem Soc

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Lipids that contain polyunsaturated fatty acids (PUFA) have therapeutic value. PUFA, however, degrade in high-temperature, oxygen-rich conditions typical of conventional hot solvent-extraction and distillation methods. Supercritical CO 2 extraction was chosen as an alternative method to recover these valuable compounds from the lower fungus, Pythium irregulare. Freeze-dried biomass was subjected to an aqueous phase and placed into a flow-through extraction apparatus. Extraction of oil from this biomass showed some success for moisture contents as high as 30% (wet basis). The addition of a novel CO 2 -philic surfactant to the wet biomass with moisture contents as high as 95% (wet basis) increased the extraction rate of fungal oil by more than an order of magnitude. For tests with extraction times of 5 to 6 h, data for the diffusioncontrolled region were modeled with an analytical solution to Fick's second law. Equilibrium data were also obtained for the fungal oil at two isotherms (40 and 60°C) over a pressure range of 13.7 to 27.5 MPa.Paper no. J8977 in JAOCS 76, 595-602 (May 1999).

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Modelling of the supercritical fluid extraction of monocrotaline from Crotalaria Spectabilis

Cited by 16 publications

References 5 publications

Off-line Supercritical Fluid Extraction and Capillary Gas Chromatography of Pyrrolizidine Alkaloids in Senecio Species

Off-line Supercritical Fluid Extraction and Capillary Gas Chromatography of Pyrrolizidine Alkaloids in Senecio Species

Some Advances in Supercritical Fluid Extraction for Fuels, Bio-Materials and Purification

Supercritical carbon dioxide extraction of lipids from Pythium irregulare

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