Modeling anxiety using adult zebrafish: A conceptual review

Stewart, Adam; Gaikwad, Siddharth; Kyzar, Evan J.; Green, Jeremy; Roth, Andrew; Kalueff, Allan V.

doi:10.1016/j.neuropharm.2011.07.037

Cited by 323 publications

(243 citation statements)

References 143 publications

(192 reference statements)

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“…27,31,[50][51][52][53][54][55][56][57][58] For example, zebrafish swimming can be quantified using video-tracking software assessing velocity, distance traveled, and time spent moving during the trial. 11,29,36,[59][60][61][62][63][64][65] Recently developed software tools enable automated quantification of complex zebrafish group behavior, such as shoaling.…”

Section: Glossarymentioning

confidence: 99%

Towards a Comprehensive Catalog of Zebrafish Behavior 1.0 and Beyond

et al. 2013

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Zebrafish (Danio rerio) are rapidly gaining popularity in translational neuroscience and behavioral research. Physiological similarity to mammals, ease of genetic manipulations, sensitivity to pharmacological and genetic factors, robust behavior, low cost, and potential for high-throughput screening contribute to the growing utility of zebrafish models in this field. Understanding zebrafish behavioral phenotypes provides important insights into neural pathways, physiological biomarkers, and genetic underpinnings of normal and pathological brain function. Novel zebrafish paradigms continue to appear with an encouraging pace, thus necessitating a consistent terminology and improved understanding of the behavioral repertoire. What can zebrafish 'do', and how does their altered brain function translate into behavioral actions? To help address these questions, we have developed a detailed catalog of zebrafish behaviors (Zebrafish Behavior Catalog, ZBC) that covers both larval and adult models. Representing a beginning of creating a more comprehensive ethogram of zebrafish behavior, this effort will improve interpretation of published findings, foster cross-species behavioral modeling, and encourage new groups to apply zebrafish neurobehavioral paradigms in their research. In addition, this glossary creates a framework for developing a zebrafish neurobehavioral ontology, ultimately to become part of a unified animal neurobehavioral ontology, which collectively will contribute to better integration of biological data within and across species.

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Section: Glossarymentioning

confidence: 99%

Towards a Comprehensive Catalog of Zebrafish Behavior 1.0 and Beyond

et al. 2013

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“…60,66,67 Parker et al 60 reported that exposure to 0.12% ethanol from 48 to 216 hpf caused adult zebrafish to spend significantly more time at the bottom of the tank compared to untreated controls. This behavior is interpreted as elevated anxiety.…”

Section: Zebrafish Models Of Fasdmentioning

confidence: 99%

Fishing for Fetal Alcohol Spectrum Disorders: Zebrafish as a Model for Ethanol Teratogenesis

2016

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Fetal Alcohol Spectrum Disorders (FASD) describes a wide array of ethanol-induced developmental defects, including craniofacial dysmorphology and cognitive impairments. It affects *1 in 100 children born in the United States each year. Due to the pleiotropic effects of ethanol, animal models have proven critical in characterizing the mechanisms of ethanol teratogenesis. In this review, we focus on the utility of zebrafish in characterizing ethanolinduced developmental defects. A growing number of laboratories have focused on using zebrafish to examine ethanol-induced defects in craniofacial, cardiac, ocular, and neural development, as well as cognitive and behavioral impairments. Growing evidence supports that genetic predisposition plays a role in these ethanol-induced defects, yet little is understood about these gene-ethanol interactions. With a high degree of genetic amenability, zebrafish is at the forefront of identifying and characterizing the gene-ethanol interactions that underlie FASD.

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“…However, the evidence summarized here shows that translational neuroscience research benefits markedly from a complementary use of zebrafish models to understand evolutionarily conserved phenotypes, pathways and circuits (Guo et al, 2012;Okamoto et al, 2012). Together with novel techniques developed in various zebrafish laboratories and rich data collected on adult and larval behavioral phenotypes (Blaser et al, 2010;Maximino et al, 2010b;Sackerman et al, 2010;Piato et al, 2011;Guo et al, 2012;Okamoto et al, 2012;Stewart et al, 2012), this provides a significant contribution to multidisciplinary, cross-species neurobehavioral research. Therefore, it is time to move full-speed forward -from discussing whether or not fish have emotionality to addressing more important fundamental questions of zebrafish affective behaviors and their proximate mechanisms.…”

Section: Concluding Remar Ksmentioning

confidence: 96%

“…The importance of zebrafish in affective research, and the growing recognition of this field, are reflected by the number of articles for the keywords zebrafish and anxiety (currently 74 PubMed publications from over 25 active laboratories worldwide, including 21 publications in 2011, and 20 publications in 2012; also see detailed reviews in (Blaser et al, 2010;Maximino et al, 2010b;Sackerman et al, 2010;Piato et al, 2011;Guo et al, 2012;Okamoto et al, 2012;Stewart et al, 2012)). …”

Section: Concluding Remar Ksmentioning

confidence: 99%

Time to recognize zebrafish ‘affective’ behavior

Vernier

Kyzar

Maximino

et al. 2012

Behav

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Widely used in biomedical research, zebrafish (Danio rerio) are steadily gaining popularity as a model organism for studying neurobehavioral phenomena. Here, we focus on to the growing spectrum of zebrafish behavioral phenotypes and the 'bigger' biological problems these models help to address. Emphasizing the developing potential of zebrafish as a model organism in biological psychiatry, we discuss several questions related to this field: Do zebrafish have 'emotional'-like behaviors? What are their neural circuits, biomarkers, and ontogenetic origins? And, finally, how can we use this knowledge to build translational bridges to understand human emotions, motivation and personality? Representing a joint effort of several established neurobehavioral laboratories, this article outlines the mounting evidence to support emotionality in zebrafish and other fishes. This conclusion is important to justify the validity of zebrafish 'affective' paradigms and their utility for basic/translational research of normal and pathological behaviors.

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Modeling anxiety using adult zebrafish: A conceptual review

Cited by 323 publications

References 143 publications

Towards a Comprehensive Catalog of Zebrafish Behavior 1.0 and Beyond

Towards a Comprehensive Catalog of Zebrafish Behavior 1.0 and Beyond

Fishing for Fetal Alcohol Spectrum Disorders: Zebrafish as a Model for Ethanol Teratogenesis

Time to recognize zebrafish ‘affective’ behavior

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