Time to recognize zebrafish ‘affective’ behavior

Vernier, Philippe; Kyzar, Evan J.; Maximino, Caio; Tierney, Keith B.; Gebhardt, Michael; Lange, Merlin; Jesuthasan, Suresh; Stewart, Adam; Neuhauss, Stephan C. F.; Robinson, Kyle; Norton, William; Herculano, Anderson Manoel; Cachat, Jonathan; Tropepe, Vincent; Landsman, Samuel; Wisenden, Brian D.; Bally‐Cuif, Laure; Kalueff, Allan V.

doi:10.1163/1568539x-00003030

Cited by 57 publications

(26 citation statements)

References 92 publications

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“…For this study, we utilized the zebrafish vertebrate model system. Zebrafish have grown in popularity since the 1990s in their use for developmental biology and toxicology (Kalueff et al, 2012). Due to their predictive model for human development, the zebrafish make for a highly effective System (Aquatic Habitats, Apopka, FL).…”

Section: Methodsmentioning

confidence: 99%

Water Contaminated With the Herbicide Atrazine: Alteration of Cancer Associated Tumor Protein D52-like 1 (tpd52l1) Gene Using the Zebrafish Model

Thanki¹

2017

JPUR

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Section: Methodsmentioning

confidence: 99%

Water Contaminated With the Herbicide Atrazine: Alteration of Cancer Associated Tumor Protein D52-like 1 (tpd52l1) Gene Using the Zebrafish Model

Thanki¹

2017

JPUR

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“…Nonetheless, zebrafish is the most widely studied species when it comes to responses to threatening and aversive stimuli (Jesuthasan & Mathuru, 2008;Maximino et al, 2010a;Kalueff et al, 2012;Gerlai, 2013).…”

Section: Monoaminergic Innervation In Teleostsmentioning

confidence: 99%

“…The terms "anxiety-like behaviour" and "fear-like behaviour" are commonly used to refer to defensive behaviour in rodents, and increasingly being used to describe behavioural patterns in fish (especially zebrafish; cf. Kalueff et al (2012) for a discussion). For the sake of clarity, the term "defensive behaviour" is used to refer to these tests and assays.…”

Section: Monoaminergic Innervation In Teleostsmentioning

confidence: 99%

The Integration of Sociality, Monoamines, and Stress Neuroendocrinology in Fish Models: Applications in the Neurosciences

Soares

Maximino

2018

Preprint

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Animal-focused research has been crucial for scientific advancement however, in this matter, rodents are still taking a starring role. Coming out from merely being supportive of evidence found in rodents, the use of fish models has slowly taken a more central role and expanded its overall contributions in areas such as social sciences, evolution, physiology, and recently in translational medical research. In neurosciences, zebrafish has been widely adopted, contributing to our understanding of the genetic control of brain processes, and the effects of pharmacological manipulations. However, discussion continues regarding the paradox of function versus structure, when fish and mammals are compared, and on the potentially evolutionarily conserved nature of behaviour across fish species. From the behavioural stand point we explored aversive/stress and social behaviour in selected fish models, and refer to the extensive contributions of stress and monoaminergic systems. We suggest that, in spite of marked neuroanatomical differences between fish and mammals, stress and sociality are conserved at the behavioural and molecular levels. We also suggest that stress and sociality are mediated by monoamines in predictable and non-trivial ways, and that monoamines could "bridge" the relationship between stress and social behaviour. To reconcile the level of divergence with the level of similarity, we need neuroanatomical, pharmacological, behavioural, and ecological studies conducted in the laboratory and in nature.These areas need to add to each other to enhance our understanding of fish behaviour and ultimately how this all may translate to better model systems for translational studies.

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“…In addition to its roles in reward and resource seeking, the mesolimbic system is also involved in coping and in the individual's ability to adapt to chronic social stress (Kvetnansky et al, 2009; in fish, those responses are also segregated at the behavioural and neuroanatomical levels is still debated (Kalueff et al, 2012).…”

Section: Stress and Sociality Network In The Vertebrate Brainmentioning

confidence: 99%

“…Nonetheless, zebrafish is the most widely studied species when it comes to fear, anxiety, and stress (Jesuthasan & Mathuru, 2008;Maximino et al, 2010a;Kalueff et al, 2012;Gerlai, 2013). Two assays -the novel tank test (Egan et al, 2009) and the light/dark test (Maximino et al, 2010b) -are widely used in this species, with good pharmacological validation and construct validity for both tests Kysil et al, 2017).…”

Section: Monoaminergic Innervation In Teleostsmentioning

confidence: 99%

The Integration of Sociality, Monoamines, and Stress Neuroendocrinology in Fish Models: Applications in the Neurosciences

Soares¹,

Maximino²

2018

Preprint

Self Cite

View full text Add to dashboard Cite

Animal-focused research has been crucial for scientific advancement however, in this matter, rodents are still taking a starring role. Coming out from merely being supportive of evidence found in rodents, the use of fish models has slowly taken a more central role and expanded its overall contributions in areas such as social sciences, evolution, physiology, and recently in translational medical research. In neurosciences, zebrafish has been widely adopted, contributing to our understanding of the genetic control of brain processes, and the effects of pharmacological manipulations. However, discussion continues regarding the paradox of function versus structure, when fish and mammals are compared, and on the potentially evolutionarily conserved nature of behaviour across fish species. From the behavioural stand point we explorted aversive/stress and social behaviour in selected fish models, and refer to the extensive contributions of stress and monoaminergic systems. We suggest that, in spite of marked neuroanatomical differences between fish and mammals, stress and sociality are conserved at the behavioural and molecular levels. We also suggest that stress and sociality are mediated by monoamines in predictable and non-trivial ways, and that monoamines could “bridge” the relationship between stress and social behaviour. To reconcile the level of divergence with the level of similarity, neuroanatomy, pharmacology, behavioural analysis, and ecology studies conducted in the laboratory and in nature need to add to each other and enhance our understanding of fish behaviour and ultimately how this all may translate to better model systems for translational studies.

show abstract

Time to recognize zebrafish ‘affective’ behavior

Cited by 57 publications

References 92 publications

Water Contaminated With the Herbicide Atrazine: Alteration of Cancer Associated Tumor Protein D52-like 1 (tpd52l1) Gene Using the Zebrafish Model

Water Contaminated With the Herbicide Atrazine: Alteration of Cancer Associated Tumor Protein D52-like 1 (tpd52l1) Gene Using the Zebrafish Model

The Integration of Sociality, Monoamines, and Stress Neuroendocrinology in Fish Models: Applications in the Neurosciences

The Integration of Sociality, Monoamines, and Stress Neuroendocrinology in Fish Models: Applications in the Neurosciences

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