Model-Based Sensor-Augmented Pump Therapy

Upcoming Devices for Diabetes Management: The Artificial Pancreas as the Hallmark Device

“…Progress in designing and evaluating these next steps has occurred at a rapid pace over the last 5 years. 24 Evaluating first overnight closed loop, multiple groups of investigators from academia and industry have developed a variety of algorithms for insulin delivery that use fuzzy logic 25 or are based on model-predictive 26 or predictive/ integrative and derivative algorithms, 27 to name a few. Variable combinations of sensors and insulin pump systems have supported early clinical trials with these algorithms that have extended beyond the inpatient setting, to diabetes camps 25 and patients' homes, 25,26,28 and these trials have provided encouraging and reassuring results that insulin can be delivered in a safe and effective way via these algorithms over the nighttime period.…”