MOCVD-Fabricated TiO₂Thin Films: Influence of Growth Conditions on Fibroblast Cells Culture

Abstract

TiO 2 thin films with various morphologies were grown on Ti substrates by the LP-MOCVD technique (Low Pressure Chemical Vapour Deposition from Metal-Organic precursor), with titanium tetra-iso-propoxide as a precursor. All the films were prepared in the same conditions except the deposition time. They were characterized by X-ray diffraction, scanning electron microscopy, optical interferometry, water contact angle measurements. MOCVD-fabricated TiO 2 thin films are known to be adapted to cell culture for implant requirements. Human gingival fibroblasts were cultured on the various TiO 2 deposits. Differences in cell viability (MTT tests) and cell spreading (qualitative assessment) were observed and related to film roughness, wettability and allotropic composition.

Effect of nano-topographical features of Ti/TiO2 electrode surface on cell response and electrochemical stability in artificial saliva

“…In the last decades, many approaches have been made to improve the surface activity of Ti-and Ti alloys, by modifying TiO 2 properties using chemical and physical procedures, while taking into account that being a bioinert material, a Ti implant becomes encapsulated into the living body by a fibrous tissue. The changing crystallinity and roughness of TiO 2 as example using MOCVD (physical chemical deposition from organo metallic precursor) [16,17] or various coatings as hydroxyapatite [18][19][20] or collagen [21] is a way to get a better integration into the bone and represented conventional methods in surface modification techniques. [22][23][24][25][26][27].…”

Atomic Layer Deposition of W:Al2O3 Nanocomposite Films with Tunable Resistivity

“…Thin film materials comprised of blended conducting and insulating components have been utilized in a wide variety of applications including resistive layers for electron multipliers such as microchannel plates,1–3 resistive memories,4–8 electro‐chromic devices,9–15 biomedical devices,16–18 and charge‐dissipating coatings on micro‐electromechanical systems (MEMS) devices 19–23. The physical and electrical properties of composite thin films can be tailored by adjusting the relative proportions of the constituent materials.…”

Effects of LP-MOCVD prepared TiO2 thin films on the in vitro behavior of gingival fibroblasts

“…The long-term success of implants most importantly requires stable interfacial interactions between biomaterial and the surrounding tissue. Therefore, different surface modification approaches have been attempted to improve the bioactive bonebinding capacity of titanium metal [6][7][8][9][10][11][12][13]. They have been applied doi:10.1016/j.matchemphys.2010.…”

“…To our knowledge, the few studies devoted to the elucidation of in vitro interactions of the cells with TiO 2 in different physical states deal with TiO 2 particles blasted on Ti substrates [17], oxide layers prepared by MOCVD [11,[14][15][16] or anodic oxidation [18,19], cluster-assembled nanostructured TiO 2 films [20], and sol-gelderived titanium oxide [21,22].…”