MMP9: A Tough Target for Targeted Therapy for Cancer

Augoff, Katarzyna; Hryniewicz-Jankowska, Anita; Taboła, Renata; Stach, Kamilla

doi:10.3390/cancers14071847

Cited by 81 publications

(61 citation statements)

References 190 publications

(213 reference statements)

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“…Therefore, decreased T and NK cell activity causes a decreased level of IFN-γ and thus contributes to tumor progression (Ayers et al, 2017) (Gato-Cañas et al, 2017. The results of the current study are in agreement with those of (Somiari et al, 2006), in which it was found that the level of MMP-9 was elevated in breast cancer patients compared to healthy controls, Matrix Metalloproteinases (MMPs) contribute to ECM degradation of the extracellular matrix as they degrade basement membrane components such as type IV collagen and increase vascular permeability (Quintero-Fabián et al, 2019) thus facilitating cancer invasion, its concentration rises in the case of inflammation and wound healing (Augoff et al, 2022), It also has important physiological and pathological roles, such as fetal tissue remodeling. wound healing and other cellular processes, such as activating and directing adhesion molecules, TNF-α, and fas ligand (Javadian et al, 2019).…”

Section: Resultssupporting

confidence: 87%

relationship between cellular mediators (IL-1β, IFN–γ, MMP-9) in Iraqi women with breast cancer

Al-Mashhadani

Alabassi

Mahood

2022

ijhs

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Breast cancer is the most common type of cancer in Iraq. The incidence of breast cancer has increased among Iraqi women in the past two decades, as it represents one of the main threats to women's health. This steady aimed To evaluate the level of some immune factors Interleukin-1β (IL-1β), Interferon- γ (IFN–γ), and Matrix metalloproteinase-9 (MMP-9), and find the relationship between these immune factors in Iraqi women diagnosed with breast cancer. Material and method Fifty women diagnosed with breast cancer were enrolled in this study in addition to 25 healthy individuals as a control group. Level (IL-1β, IFN-γ, MMP-9) was measured using ELISA technology. Conclusion The expression level of (IL-1β, IFN-γ, MMP-9) increased in women with breast cancer in different age groups, but the age group (40-49) also recorded the highest expression of these cellular mediators. Regarding the relationship of (MMP-9), it was not significant with (IL-1β), but it was significant with (IFN-γ) (p≤0.05), and about the relationship between (IL-1β) and (IFN-γ) it was no significant negatively, that Increased level of (IL-1β, IFN-γ, MMP-9) expression could be a predictive marker of breast cancer.

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Section: Resultssupporting

confidence: 87%

relationship between cellular mediators (IL-1β, IFN–γ, MMP-9) in Iraqi women with breast cancer

Al-Mashhadani

Alabassi

Mahood

2022

ijhs

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“…During the development of cancer, due to its capacity to degrade extracellular protein components, MMP9 is involved in the removal of physical barriers to cell migration. The disruption of the basement membrane (BM), which consists of a dense network of crosslinked laminins and collagens, not only facilitates the spread of invading cancer cells or the influx of immune cells into the tumor stroma but also facilitates the formation of new blood and lymphatic vessels that are necessary for supplying tumor tissue with nutrients and oxygen (Augoff et al, 2022). TAMs play a crucial role in the development of malignancies, which makes it an appealing target for cancer therapy.…”

Section: Discussionmentioning

confidence: 99%

Supercritical fluid extract of Angelica sinensis promotes the anti-colorectal cancer effect of oxaliplatin

et al. 2022

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Oxaliplatin-based chemotherapy regimens are recommended for patients with advanced colorectal cancer (CRC). However, oxaliplatin (OXA) can cause toxic side effects at the recommended dosage. Therefore, it is necessary to find new drug candidates that can synergize with OXA and thereby lower the OXA dose while still maintaining its efficacy. Angelica sinensis is a common drug in traditional Chinese medicine and has demonstrated a significant anti-CRC effect in modern pharmacological studies. The active ingredients in Angelica sinensis can be effectively extracted by a supercritical fluid extract. In this study, the supercritical fluid extract of Angelica sinensis (A-SFE) was obtained by a stable extraction process and was chemically characterized by GC/MS. The anti-cancer effect of A-SFE when applied individually was explored in vitro through MTT, scratch, and Transwell assay. The effect of A-SFE on CRC cells under the influence of tumor-associated macrophages (TAMs) was explored by a co-culture model. The results showed that A-SFE could inhibit the viability, metastasis, and invasion of HCT116 cells, especially under the influence of TAMs. When 20–100 μg/ml of A-SFE and 8–64 μg/ml of OXA were used in combination in HCT116 cells, synergistic or additive effects were shown in different concentration combinations. The CT26 syngeneic mouse model was used to explore the anti-CRC effect of OXA combined with A-SFE in vivo. The tumor volume, expression levels of Ki67, MMP9, and CD206 in the OXA + A-SFE group were less than those in the OXA group. In conclusion, A-SFE has the potential to become an adjuvant drug for OXA in the treatment of CRC, which provides new strategies for anti-colorectal cancer research.

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“…IL-6 induces STAT phosphorylation to bind in the MMP9 promoter site and elevates the transcription of MMP9. Due to the function of reorganizing extracellular matrix by MMP9 ( 141 ), tumor cells invade other organs. PGE2 carried by prostate cancer-derived EVs binds to receptors EP2/EP4 on DCs to upregulate the CD73 expression, while the adenosine monophosphate (AMP)-depends on expressions of IL-12 and TNF-α decrease subsequently ( 142 ).…”

Section: Dendritic Cellsmentioning

confidence: 99%

Tumor-derived extracellular vesicles modulate innate immune responses to affect tumor progression

et al. 2022

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Immune cells are capable of influencing tumor progression in the tumor microenvironment (TME). Meanwhile, one mechanism by which tumor modulate immune cells function is through extracellular vesicles (EVs), which are cell-derived extracellular membrane vesicles. EVs can act as mediators of intercellular communication and can deliver nucleic acids, proteins, lipids, and other signaling molecules between cells. In recent years, studies have found that EVs play a crucial role in the communication between tumor cells and immune cells. Innate immunity is the first-line response of the immune system against tumor progression. Therefore, tumor cell-derived EVs (TDEVs) which modulate the functional change of innate immune cells serve important functions in the context of tumor progression. Emerging evidence has shown that TDEVs dually enhance or suppress innate immunity through various pathways. This review aims to summarize the influence of TDEVs on macrophages, dendritic cells, neutrophils, and natural killer cells. We also summarize their further effects on the progression of tumors, which may provide new ideas for developing novel tumor therapies targeting EVs.

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MMP9: A Tough Target for Targeted Therapy for Cancer

Cited by 81 publications

References 190 publications

relationship between cellular mediators (IL-1β, IFN–γ, MMP-9) in Iraqi women with breast cancer

relationship between cellular mediators (IL-1β, IFN–γ, MMP-9) in Iraqi women with breast cancer

Supercritical fluid extract of Angelica sinensis promotes the anti-colorectal cancer effect of oxaliplatin

Tumor-derived extracellular vesicles modulate innate immune responses to affect tumor progression

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