Tumor-derived extracellular vesicles modulate innate immune responses to affect tumor progression

Wang, Siqi; Sun, Jiaxin; Dastgheyb, Raha; Li, Zhigang

doi:10.3389/fimmu.2022.1045624

Cited by 13 publications

(9 citation statements)

References 193 publications

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“…Macrophages, which are present in various parts of the body, perform crucial functions by regulating the immune system, inflammatory responses, antigen presentation, angiogenesis, and remodeling [ 36 ]. The tumor microenvironment (TME) is enriched with tumor-associated macrophages (TAM), which are key drivers of tumor progression, metastasis, and therapeutic resistance [ 37 ].…”

Section: Biogenesis and Sourcementioning

confidence: 99%

Exosome-based delivery strategies for tumor therapy: an update on modification, loading, and clinical application

Yang,

Li,

et al. 2024

J Nanobiotechnol

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Malignancy is a major public health problem and among the leading lethal diseases worldwide. Although the current tumor treatment methods have therapeutic effect to a certain extent, they still have some shortcomings such as poor water solubility, short half-life, local and systemic toxicity. Therefore, how to deliver therapeutic agent so as to realize safe and effective anti-tumor therapy become a problem urgently to be solved in this field. As a medium of information exchange and material transport between cells, exosomes are considered to be a promising drug delivery carrier due to their nano-size, good biocompatibility, natural targeting, and easy modification. In this review, we summarize recent advances in the isolation, identification, drug loading, and modification of exosomes as drug carriers for tumor therapy alongside their application in tumor therapy. Basic knowledge of exosomes, such as their biogenesis, sources, and characterization methods, is also introduced herein. In addition, challenges related to the use of exosomes as drug delivery vehicles are discussed, along with future trends. This review provides a scientific basis for the application of exosome delivery systems in oncological therapy. Graphical Abstract

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Section: Biogenesis and Sourcementioning

confidence: 99%

Exosome-based delivery strategies for tumor therapy: an update on modification, loading, and clinical application

Yang,

Li,

et al. 2024

J Nanobiotechnol

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“…EVs derived from tumors can modulate the immune responses of the host through a range of pathways, which includes promoting pro-inflammatory effects ( Wang et al, 2022 ). Tumor-derived EVs induce monocytes to release pro-inflammatory cytokines.…”

Section: Immune Cells and Tumor Cell-derived Evs Act As Modulators Of...mentioning

confidence: 99%

The role of extracellular vesicles in cholangiocarcinoma tumor microenvironment

Zhang,

Shu,

Liu

et al. 2024

Front. Pharmacol.

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Cholangiocarcinoma (CCA) is a highly aggressive malignant tumor that originates from the biliary system. With restricted treatment options at hand, the challenging aspect of early CCA diagnosis leads to a bleak prognosis. Besides the intrinsic characteristics of tumor cells, the generation and progression of CCA are profoundly influenced by the tumor microenvironment, which engages in intricate interactions with cholangiocarcinoma cells. Of notable significance is the role of extracellular vesicles as key carriers in enabling communication between cancer cells and the tumor microenvironment. This review aims to provide a comprehensive overview of current research examining the interplay between extracellular vesicles and the tumor microenvironment in the context of CCA. Specifically, we will emphasize the significant contributions of extracellular vesicles in molding the CCA microenvironment and explore their potential applications in the diagnosis, prognosis assessment, and therapeutic strategies for this aggressive malignancy.

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“…For immune cells and tumor vesicles, it was demonstrated that EVs can both stimulate and inhibit lymphocytes depending on ratio and membrane composition. Effects of tumor EVs on immune cells were recently reviewed in ( Ukrainskaya et al, 2019 ; Wang et al, 2022 ) Below we will discuss the role of EVs produced by glioma/glioblastoma in establishment of immune suppressive microenvironment.…”

Section: Extracellular Vesicles Transfer Information Between Cellsmentioning

confidence: 99%

Effects of glioblastoma-derived extracellular vesicles on the functions of immune cells

Musatova

Rubtsov

2023

Front. Cell Dev. Biol.

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Glioblastoma is the most aggressive variant of glioma, the tumor of glial origin which accounts for 80% of brain tumors. Glioblastoma is characterized by astoundingly poor prognosis for patients; a combination of surgery, chemo- and radiotherapy used for clinical treatment of glioblastoma almost inevitably results in rapid relapse and development of more aggressive and therapy resistant tumor. Recently, it was demonstrated that extracellular vesicles produced by glioblastoma (GBM-EVs) during apoptotic cell death can bind to surrounding cells and change their phenotype to more aggressive. GBM-EVs participate also in establishment of immune suppressive microenvironment that protects glioblastoma from antigen-specific recognition and killing by T cells. In this review, we collected present data concerning characterization of GBM-EVs and study of their effects on different populations of the immune cells (T cells, macrophages, dendritic cells, myeloid-derived suppressor cells). We aimed at critical analysis of experimental evidence in order to conclude whether glioblastoma-derived extracellular vesicles are a major factor in immune evasion of this deadly tumor. We summarized data concerning potential use of GBM-EVs for non-invasive diagnostics of glioblastoma. Finally, the applicability of approaches aimed at blocking of GBM-EVs production or their fusion with target cells for treatment of glioblastoma was analyzed.

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Tumor-derived extracellular vesicles modulate innate immune responses to affect tumor progression

Cited by 13 publications

References 193 publications

Exosome-based delivery strategies for tumor therapy: an update on modification, loading, and clinical application

Exosome-based delivery strategies for tumor therapy: an update on modification, loading, and clinical application

The role of extracellular vesicles in cholangiocarcinoma tumor microenvironment

Effects of glioblastoma-derived extracellular vesicles on the functions of immune cells

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