Mixed germ cell sex cord–stromal tumors of the testis and ovary. Morphological, immunohistochemical, and molecular genetic study of seven cases

Reply: mixed germ cell sex cord-stromal tumors of the testis and ovary

“…We read with interest the article by Michal et al [1] describing seven cases of "mixed germ cell sex cord-stromal tumor" of the ovary and testis. Their observations concerning fundamental differences in the nature of this "entity" in the two gonads are in line with our experience.…”

Mixed germ cell sex cord-stromal tumours of the testis

“…The immunoprofile of the germ cells in ovarian MGSCT was identical to that of ovarian dysgerminomas and testicular classical seminomas. In addition, germ cells in one of the ovarian cases showed amplification of 12p, which is a typical feature of ovarian dysgerminomas and testicular classical seminomas [1].…”

“…Dear Editor, We have recently published a series of seven cases of mixed germ cell sex cord-stromal tumours (MGSCT) of the testis and ovary comparing their morphological, immunohistochemical and molecular genetic findings [1]. MGSCT of the ovary and testes varied considerably in all these aspects.…”

Mixed testicular neoplasia in a short beaked common dolphin Delphinus delphis

“…Collision tumors and true mixed tumors are infrequently reported (Maclachlan & Kennedy 2002, Michal et al 2006. A series of such tumors has been described in dogs, and a single case has been described in a stallion (Maclachlan & Kennedy 2002).…”

“…In the Sertoli cell tumors are the most hormonally active among testicular neoplasias and are usually associated with a paraneoplastic syndrome comprising feminization derived from released estrogens, which may lead to estrogen-induced pancytopenia. Other signs including bilateral symmetrical alopecia of the trunk and flanks with hyperpigmented inguinal skin, easily detachable dry skin, gynecomasty, pendulous prepuce, male attraction and bone marrow hypoplasia with arregenerative anemia are commonly described clinical signs in human and domestic animal medicine (Maclachlan & Kennedy 2002, Michal et al 2006). Despite the above, mixed germ cell−sex cord stromal tumors involving seminoma and Sertoli cell tumors do not induce hyperestrogenic syndromes and are usually benign (Maclachlan & Kennedy 2002).…”