Mixed testicular neoplasia in a short beaked common dolphin Delphinus delphis

Díaz‐Delgado, Josué; Monteros, A. Espinosa de los; Fernández-Maldonado, Carolina; Arbelo, Manuel; Quesada‐Canales, Óscar; Andrada, M.; Fernández, Ana

doi:10.3354/dao02525

Cited by 11 publications

(5 citation statements)

References 13 publications

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“…Testicular neoplasms have been only infrequently reported in marine mammals worldwide, but a testicular neoplasia in a common dolphin involving a Sertoli cell tumour, an interstitial (Leydig) cell tumour, and a seminoma was found in an individual that stranded on the Almerian coastline (Alboran Sea; Díaz‐Delgado et al, 2012). Furthermore, a lymphatic spread of the Sertoli cell tumour to an adjacent retroperitoneal lymph node was observed.…”

Section: Threatsmentioning

confidence: 99%

See 1 more Smart Citation

The conservation of the endangered Mediterranean common dolphin (Delphinus delphis): Current knowledge and research priorities

Vella

Murphy

Giménez

et al. 2021

Aquatic Conservation

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1. Preservation of endangered species is now recognized as a relevant component of regional and global conservation actions achieved through the maintenance of the remaining populations in a favourable conservation status. The Mediterranean common dolphin (Delphinus delphis) is listed as an Endangered subpopulation in the International Union for Conservation of Nature Red List, with declining numbers in some of the areas where it has been studied for numerous years. Prey depletion, fisheries bycatch, pollution, health risks, and climate change are among the recognized threats that the species is facing in the region.2. The existing national, regional, and international legislation pertinent to Mediterranean countries should aid greater science-policy-management integration and support innovative research and monitoring towards effective conservation. The challenges inherent in studying the pelagic D. delphis should not preclude the use of long-term, year-round, multiplatform surveys, side by side with the latest molecular tools, which aid our understanding of its populations' genetic diversity, resistance to diseases, and resilience in a semi-enclosed fast-changing sea.3. Addressing the multiplicity of problems confronting the species requires collaborative effort at all levels to share and merge resources, data, and expertise more efficiently. In this review, we provide an overview of the current knowledge on the Mediterranean common dolphin, the main threats, and knowledge gaps that are priorities for addressing its conservation, while providing clear recommendations for effectively safeguarding the species and its habitat at both local and regional levels.

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Section: Threatsmentioning

confidence: 99%

“…Furthermore, a lymphatic spread of the Sertoli cell tumour to an adjacent retroperitoneal lymph node was observed. Although confirmation of further health implications is extremely challenging in dolphins, Díaz‐Delgado et al (2012) do not rule out the metastatic potential of the tumour.…”

Section: Threatsmentioning

confidence: 99%

The conservation of the endangered Mediterranean common dolphin (Delphinus delphis): Current knowledge and research priorities

Vella

Murphy

Giménez

et al. 2021

Aquatic Conservation

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“…Additional sequela observed in dogs with PMDS include uterine diseases (pyometra; hydrometra) and testicular tumors of the cryptorchid testis (Matsuu et al 2009, Wu et al 2009. In cetaceans, intra-abdominal location of testis is physiological, with testicular tumors being rare (Díaz-Delgado et al 2012). In this case, additional sequela was observed in the form of a hydrometra.…”

Section: Discussionmentioning

confidence: 67%

Persistent Mü̈llerian duct syndrome in a beluga whale Delphinapterus leucas

Stimmelmayr

Ferrer²,

Rotstein³

2019

Dis. Aquat. Org.

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This case study describes a persistent Müllerian duct syndrome (PMDS), a rare form of XY disorder of sex development (DSD), in a mature (>15 yr) beluga whale Delphinapterus leucas. The phenotypically and genetically male beluga whale had both Müllerian (parameso nephric) and Wolffian (mesonephric) duct derivatives. A mild hydrometra was present. Gross and histological analyses indicated the testes were atrophied. Histopathologic findings in the testes also included fibrosis in addition to ductus deferens ductular dilation, epididymal ductular dilation, lymphoplasmacytic balanitis, uterine glandular atrophy, and endometrial fibrosis. DSDs are rarely reported in cetaceans, and PMDS has never been described in a cetacean.

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“…Few reports exist regarding testicular neoplasms in cetaceans (Geraci et al 1987, Van Bressem et al 2000, Estep et al 2005, Díaz-Delgado et al 2012, Díaz-Santana et al 2020, Page-Karjian et al 2020, with a Sertoli cell tumour reported in a spotted dolphin Stenella frontalis (Estep et al 2005) and a shortbeaked common dolphin Delphinus delphis (Díaz-Delgado et al 2012). Metastases are rare and indicate a malignant transformation (Littleton et al 1981), as pre viously described in a common dolphin (Díaz-Delgado et al 2012) and observed in this case. Although Sertoli cell tumours can be functional, there was no evidence of hormonal activity in the form of feminisation manifested by gynaecomastia, contralateral testicular or bone marrow atrophy (Post & Kilborn, 1987).…”

Section: Discussionmentioning

confidence: 99%

Spontaneous neoplasms in harbour porpoises Phocoena phocoena

Gregor¹,

Lakemeyer²,

IJsseldijk³

et al. 2022

Dis. Aquat. Org.

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Harbour porpoises are widely distributed in the North Atlantic and represent the most abundant cetacean species in the North and Baltic Seas. Spontaneous neoplasms are relatively rarely reported in cetaceans, and only little is known about neoplasia in harbour porpoises. Thus, archival material was reviewed for spontaneous neoplasms in harbour porpoises recorded during post-mortem examinations between 1999 and 2018. Neoplasms were identified in 7 adult porpoises: 6 animals originating from the North and Baltic Seas and investigated as part of German and Dutch systematic health monitoring programs, and 1 porpoise from Greenlandic waters. The tumours were of different histogenetic origins and further characterised by histology and immunohistochemistry. One individual had a neoplasia in the digestive tract (adenocarcinoma, n = 1); 4 animals, in the genital tract (Sertoli cell tumour, n = 1; genital leiomyoma/fibroleiomyoma, n = 3); and 2 porpoises, in endocrine organs (adrenal adenoma, n = 2). This is the first report of an adenocarcinoma in the liver, a testicular Sertoli cell tumour and adrenocortical adenomas in harbour porpoises. The cause of the tumorigenesis in examined cases remains undetermined. The involvement of endogenous factors, including mutation of cell cycle regulating genes, such as the tumour-suppressor gene p53, cannot be ruled out. The aetiopathogenetic significance of exogenous factors, such as infectious agents like liver flukes or anthropogenic factors, including persistent organic pollutants, should be the subject of future investigations.

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Mixed testicular neoplasia in a short beaked common dolphin Delphinus delphis

Cited by 11 publications

References 13 publications

The conservation of the endangered Mediterranean common dolphin (Delphinus delphis): Current knowledge and research priorities

The conservation of the endangered Mediterranean common dolphin (Delphinus delphis): Current knowledge and research priorities

Persistent Mü̈llerian duct syndrome in a beluga whale Delphinapterus leucas

Spontaneous neoplasms in harbour porpoises Phocoena phocoena

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