Mixed epithelial and stromal tumor of the kidney

Abstract

A 44-year-old woman who underwent radical nephrectomy due to a left renal mass presented to our clinic. Results of the histopathological examination showed a mixed epithelial and stromal tumor of the kidney, a rare benign lesion of the kidney. The epidemiology, histopathological features, imaging features, possible pathogeneses, and treatment alternatives are discussed, and the relevant literature is reviewed. The postoperative course was uneventful, and the patient was free of local recurrence or metastasis until the last follow-up (12 months).

Mixed Epithelial and Stromal Tumor of the Kidney: A Rare Case Report

“…Generally MESTK are composed of solid and cystic areas grossly [5,12,13]. In our case tumor was composed of only solid areas with no cystic component.…”

“…It was first described in 1973 by Block et al as congenital mesoblastic nephroma [3,4]. The term MESTK was introduced by Michal et al in 1998 [5,6]. These tumors were diagnosed as leiomyomatous renal hamartomas, congenital mesoblastic nephroma in an adult, cystic hamartoma of renal pelvis, solitary multilocular cyst with Mullerian like stroma and adult metanephric stromal tumor in the past [4].…”

“…It is generally seen in premenopausal woman and the average age is 46 years [4,5]. Female to male ratio is striking, which is (10:1) [4].…”

“…History of long term estrogen replacement therapy in females and hormonal therapy in male patients shows that a hormonal mechanism plays role in etiology of these tumors [4,5].…”

“…Most of the patients present with flank pain, palpable mass, hematuria and urinary tract infection as like other renal tumors, but 25% of the cases are identified incidentally and are asymptomatic [4,5,8,9].…”