Mixed cryoglobulinemia and hepatitis C virus

Cacoub, Patrice; Fabiani, F; Musset, Lucile; Perrin, M.; Frangeul, Lionnel; Léger, J.-M.; Huraux, Jean‐Marie; Piette, Jean‐Charles; Godeau, P

doi:10.1016/0002-9343(94)90132-5

Cited by 212 publications

(122 citation statements)

References 30 publications

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“…The first studies came from Italy, and studies from France, Japan, the United States, and England followed. HCV prevalence in these series was between 0.004% and 33% [19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36]. The lowest prevalence was found in a British study, where 1 out of 268 lymphoma patients had tumors positive for HCV.…”

Section: Discussionmentioning

confidence: 99%

Detection of hepatitis C virus RNA in paraffin‐embedded tissues from patients with non‐Hodgkin's lymphoma

et al. 2004

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The aim of this study is to detect the possible role of hepatitis C Virus (HCV) in lymphomagenesis. HCV‐RNA and anti‐HCV antibodies were studied in tissue and serum samples taken from patients with non‐Hodgkin's Lymphoma (NHL). The prevalence of HCV, the clinical presentation of these cases, and association with histologic subtypes were determined. RT‐PCR was used to detect the HCV‐RNA in serum and tissue samples. The anti‐HCV antibodies were tested with microparticle enzyme immunoassay. Immunohistochemistry with the ABC method was used to detect the HCV core protein in HCV‐RNA+ cases. RNA could be detected in 30 of 35 cases, and other tests were performed in these 30 samples. HCV‐RNA was detected in 11 tissue samples (11/30, 37%). HCV core protein was studied in 10 of 11 HCV‐RNA+ cases, and 1–3% nuclear staining was found in only 2 samples. Serologically, HCV‐RNA was detected in 7 of 30 samples (23.3%) and anti‐HCV antibody was detected in 3 of 30 samples (10%). Detection of HCV‐RNA in 37% of the lymphoma tissue samples suggests that HCV may have a role or is a contributing factor in the pathogenesis of lymphoma. The very low HCV core protein in lymphoma tissues may be due to the low viral load in lymphoid tissues and/or higher sensitivity of the PCR method. Detection of anti‐HCV antibody in only three cases may be associated with undetectable levels of antibodies due to the immune deficiency in cases with NHL. Am. J. Hematol. 76:252–257, 2004. © 2004 Wiley‐Liss, Inc.

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Section: Discussionmentioning

confidence: 99%

Detection of hepatitis C virus RNA in paraffin‐embedded tissues from patients with non‐Hodgkin's lymphoma

et al. 2004

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“…The most prominent association between HCV and LPDs has been shown in essential mixed cryoglobulinaemia and Waldenstrom macroglobulinaemia. The prevalence of anti-HCV and/or HCV-RNA positivity has been reported as between 42 and 100% (Agnello et al, 1992;Santini et al, 1993;Ferri et al, 1993;Cacoub et al, 1994;Pozzato et al, 1994;Mussini et al, 1995). In eight studies from Italy, 25% of the patients (range 9-40%) with B-cell NHL were positive for HCV antibodies (Ferri et al, 1994;Cavanna et al, 1995;Mazzuro et al, 1996;Pioltelli et al, 1996;Silvestri et al, 1996;Usto et al, 1996;Luppi et al, 1997;de Rosa et al, 1997).…”

Section: Discussionmentioning

confidence: 99%

Prevalence of hepatitis C virus infection in patients with lymphoproliferative disorders in Southern Turkey

et al. 1999

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Anti-hepatitis C virus (HCV) antibody prevalence was investigated in 228 patients with lymphoproliferative disorders (LPDs). Twenty-six of 228 (11.40%) patients with LPDs were positive for anti-HCV which was higher than the donor population ( P = 0.0007). Nine of 98 cases with non-Hodgkin's lymphoma, five of 47 cases with multiple myeloma, seven of 36 cases with Hodgkin's disease, four of 38 cases with chronic lymphocytic leukaemia and one of nine cases with acute lymphoblastic leukaemia had anti-HCV antibody. In all patients, odds ratio (OR) for anti-HCV was 24.09. This value was higher in patients less than 35 years as 62.04 for below 25 years and 32.00 for between 25–35 years. Our findings suggest that HCV infection might be a causative and/or contributing factor in lymphoproliferation. © 1999 Cancer Research Campaign

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“…Recently a number of studies have implicated HCVinfection as the major cause of mixed cryoglobulinemia (2)(3)(4)(5)(6)(7). Patients with mixed cryoglobulinemia often showsymptoms associated with systemic vasculitis, such as purpura, arthralgia, peripheral neuropathy, and glomerulonephritis (GN).…”

Section: Introductionmentioning

confidence: 99%

Cryofiltration and Oral Corticosteroids Provide Successful Treatment for an Elderly Patient with Cryoglobulinemic Glomerulonephritis Associated with Hepatitis C Virus Infection.

et al. 2000

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A 75-year-old manwas admitted due to nephrotic syndrome, purpura on the legs, which was associated with hepatitis C virus (HCV), and type II mixed cryoglobulinemia. Renal biopsy revealed features of cryoglobulinemic glomerulonephritis. Since the patient was elderly and the HCV genotype was Ib, interferon-alpha for reducing HCVwas not indicated. Four sessions of cryofiltration and the administration of corticosteroids improved the proteinuria and renal function strikingly without adverse effects. This case demonstrates that an elderly patient who has nephrotic syndrome caused by cryoglobulinemic glomerulonephritis associated with HCVcan be treated safely by cryofiltration with low doses of oral corticosteroids.

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Mixed cryoglobulinemia and hepatitis C virus

Cited by 212 publications

References 30 publications

Detection of hepatitis C virus RNA in paraffin‐embedded tissues from patients with non‐Hodgkin's lymphoma

Detection of hepatitis C virus RNA in paraffin‐embedded tissues from patients with non‐Hodgkin's lymphoma

Prevalence of hepatitis C virus infection in patients with lymphoproliferative disorders in Southern Turkey

Cryofiltration and Oral Corticosteroids Provide Successful Treatment for an Elderly Patient with Cryoglobulinemic Glomerulonephritis Associated with Hepatitis C Virus Infection.

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