Prevalence of hepatitis C virus infection in patients with lymphoproliferative disorders in Southern Turkey

Paydas, S; Kilic, Banu; Şahin, Berksoy; Buğdaycı, Resul

doi:10.1038/sj.bjc.6690522

Cited by 36 publications

(27 citation statements)

References 22 publications

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“…In these studies, HCV prevalence was compared either with a donor population or with other nonmalignant diseases or nonlymphoid malignancies. In our previous study, the prevalence of anti-HCV was 9.18% [41]. In the present study, anti-HCV was found in 8.1% of the cases.…”

Section: Resultssupporting

confidence: 58%

“…The prevalence of HCV in NHLs and/or LPDs has been found to be between 0-38% [17,18,21,22,[24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39][40][41][42][43]. As seen in these series, prevalence was the highest in Italy, the USA, and Japan, and lowest in England and France.…”

Section: Resultsmentioning

confidence: 91%

“…In some series the average age in anti-HCV (+) cases is higher than HCV (-) lymphomas; however, in some series the OR was higher in the younger age group and no significant difference was observed in some series between HCV (+) and (-) patients [24,26,41]. In our group there was no important difference in cases with or without anti-HCV antibody, but we found younger age in cases with HCV-RNA (+).…”

Section: Resultsmentioning

confidence: 98%

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Anti‐HCV and HCV‐RNA prevalence and clinical correlations in cases with non‐Hodgkin's lymphoma

et al. 2003

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Hepatitis C virus (HCV) is an RNA virus in the Flaviviridae family. It displays lymphotropism in addition to hepatotropism and extrahepatic manifestations are very well known. There are many studies showing an association between HCV infection and non-Hodgkin's lymphomas (NHL). In this study the evidence for HCV infection was studied in cases with NHL. To this end, anti-HCV antibody and HCV-RNA were screened in serum samples of cases with NHL using third-generation ELISA and RT-PCR. Anti-HCV antibody was studied in 223 patients and was found to be positive in 18 cases (8.1%). Anti-HCV antibody positivity was compared with our blood bank / blood donor population. There was an important increased risk of HCV infection-the common odds ratio was 34.56 and corrected odds ratio was 19.07. HCV-RNA was studied in 67 of 223 serum samples. HCV-RNA was found to be positive in 21 of 67 samples (31.3%). When compared with clinicodemographic parameters for anti-HCV and HCV-RNA, including age, nodal status, and grade (in evaluable cases), except age in cases with or without HCV-RNA, we did not find an important correlation with HCV status and clinical findings (P = 0.155; 0.442; 0,558; 0.126, respectively). These results suggest that HCV infection may be an important risk factor for lymphomagenesis and HCV-RNA is more useful for the detection of HCV infection in these immunosuppressed cases. Simultaneous detection of anti-HCV and HCV-RNA will be more informative in this population. Am. J.

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Section: Resultssupporting

confidence: 58%

Section: Resultsmentioning

confidence: 91%

Section: Resultsmentioning

confidence: 98%

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Anti‐HCV and HCV‐RNA prevalence and clinical correlations in cases with non‐Hodgkin's lymphoma

et al. 2003

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“…The first studies came from Italy, and studies from France, Japan, the United States, and England followed. HCV prevalence in these series was between 0.004% and 33% [19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36]. The lowest prevalence was found in a British study, where 1 out of 268 lymphoma patients had tumors positive for HCV.…”

Section: Discussionmentioning

confidence: 99%

Detection of hepatitis C virus RNA in paraffin‐embedded tissues from patients with non‐Hodgkin's lymphoma

et al. 2004

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The aim of this study is to detect the possible role of hepatitis C Virus (HCV) in lymphomagenesis. HCV‐RNA and anti‐HCV antibodies were studied in tissue and serum samples taken from patients with non‐Hodgkin's Lymphoma (NHL). The prevalence of HCV, the clinical presentation of these cases, and association with histologic subtypes were determined. RT‐PCR was used to detect the HCV‐RNA in serum and tissue samples. The anti‐HCV antibodies were tested with microparticle enzyme immunoassay. Immunohistochemistry with the ABC method was used to detect the HCV core protein in HCV‐RNA+ cases. RNA could be detected in 30 of 35 cases, and other tests were performed in these 30 samples. HCV‐RNA was detected in 11 tissue samples (11/30, 37%). HCV core protein was studied in 10 of 11 HCV‐RNA+ cases, and 1–3% nuclear staining was found in only 2 samples. Serologically, HCV‐RNA was detected in 7 of 30 samples (23.3%) and anti‐HCV antibody was detected in 3 of 30 samples (10%). Detection of HCV‐RNA in 37% of the lymphoma tissue samples suggests that HCV may have a role or is a contributing factor in the pathogenesis of lymphoma. The very low HCV core protein in lymphoma tissues may be due to the low viral load in lymphoid tissues and/or higher sensitivity of the PCR method. Detection of anti‐HCV antibody in only three cases may be associated with undetectable levels of antibodies due to the immune deficiency in cases with NHL. Am. J. Hematol. 76:252–257, 2004. © 2004 Wiley‐Liss, Inc.

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“…OR for anti-HCV was 24.09. 2 In our second study, anti-HCV antibody was examined in 223 cases with NHL and it was found to be positive in 18 (8.1%). Common OR was 34.56 and corrected OR was 19.07.…”

mentioning

confidence: 94%

Hepatitis C virus infection and lymphomas

Paydaş

2004

Intl Journal of Cancer

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Prevalence of hepatitis C virus infection in patients with lymphoproliferative disorders in Southern Turkey

Cited by 36 publications

References 22 publications

Anti‐HCV and HCV‐RNA prevalence and clinical correlations in cases with non‐Hodgkin's lymphoma

Anti‐HCV and HCV‐RNA prevalence and clinical correlations in cases with non‐Hodgkin's lymphoma

Detection of hepatitis C virus RNA in paraffin‐embedded tissues from patients with non‐Hodgkin's lymphoma

Hepatitis C virus infection and lymphomas

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