Mitral and aortic regurgitation in Behcet's syndrome.

Peña, Jessica M.; García‐Alegría, Javier; García-Fernández, Francisco; Arnalich, Francisco; Barbado, F J; Vázquez, J. J.

doi:10.1136/ard.44.9.637

Cited by 24 publications

(12 citation statements)

References 8 publications

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“…Intrinsic valvular abnormalities have been documented in Behcet's disease, often leading to torrential mitral or aortic regurgi tation with hemodynamic decompensation [10][11][12][13], Chikamori et al [13] have recently reviewed the reports of aortic regurgitation complicating Behcet's disease in the English (6 cases) and Japanese (15 cases) literature. Intrinsic aortic valve disease was the com monest etiological factor.…”

Section: Discussionmentioning

confidence: 99%

Diffuse Aortitis Complicating Behcet’s Disease Leading to Severe Aortic Regurgitation

Tai

Fong²,

Ng³

et al. 1991

Cardiology

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Cardiovascular complications are uncommon in Behcet’s disease, but are frequently the cause of morbidity and mortality. Venous and peripheral arterial involvement have been well documented, but involvement of the proximal aorta has rarely been described. This report details a Chinese patient with Behcet’s disease. Diffuse aortitis led to proximal aortic dilatation and severe aortic regurgitation necessitating aortic valve replacement. Histopathology of the aorta revealed features similar to those observed in other systemic diseases with aortic involvement.

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Section: Discussionmentioning

confidence: 99%

Diffuse Aortitis Complicating Behcet’s Disease Leading to Severe Aortic Regurgitation

Tai

Fong²,

Ng³

et al. 1991

Cardiology

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“…[41][42][43][44] These include rheumatoid heart disease, 45,46 Behcet's disease, 47 Crohn's disease, 48 Kawasaki's disease, 49 Wegener's granulomatosis, 50 and Reiter's syndrome. 51,52 In rheumatoid arthritis, granulomatous involvement has been noted in the aortic and mitral cusps.…”

Section: Discussionmentioning

confidence: 99%

Left-Sided Cardiac Valvulitis in Tristetraprolin-Deficient Mice

Ghosh

Hoenerhoff

Clayton

et al. 2010

The American Journal of Pathology

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Inflammation may play a role in the etiology of both degenerative and rheumatic cardiac valve diseases. We report here that mice deficient in tristetraprolin (TTP) , a protein with known anti-inflammatory functions , develop severe left-sided cardiac valvulitis. TTP is an mRNA binding protein that inhibits inflammation by destabilizing the mRNA encoding tumor necrosis factor ␣ (TNF). This leads in turn to a TNF-excess syndrome characterized by systemic inflammation. Evaluation of hearts from TTP ؊/؊ mice demonstrated gross thickening of the mitral and aortic but not the tricuspid or pulmonary valves, accompanied by inflammatory cell infiltrates. To determine whether TNF played a role in the development of this valvulitis, we examined mice deficient in both TNF receptors and in TTP; four of five of these mice exhibited no histological evidence of valvulitis, but one mouse had aortic valve leaflet thickening with a cellular infiltrate. Four additional mice had no external evidence of valvular thickening. Cardiac valves of transgenic mice expressing human TNF developed mild aortic valve leaflet edema without evidence of hypercellularity. Thus, TTP deficiency in mice leads to left-sided cardiac valvulitis with prominent inflammatory cell involvement, due, at least in part, to excess TNF. These findings support the potential involvement of TNF and inflammation in the development of cardiac valve disease in man.

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“…Arterial lesions of BS are characterized by the formation of aneurysms and thromboembolic occlusion of the lumen' 3 "" 8 '. Cardiac manifestations including pericarditis' 9 ""', myocarditis' 12 ', conduction system disturbances 1 " 1 , acute myocardial infarction' 1415 ' and valvular disease 1716 " 18 ' have also been described but are rare and seldom recognized ante-mortem 1 ' 51 .…”

Section: Introductionmentioning

confidence: 98%

M-mode, 2-D and Doppler echocardiographic study in 65 patients with Behçet's syndrome

Özkan

Emel

Özdemir

et al. 1992

European Heart Journal

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The cardiac involvement in Behçet's syndrome in sixty-five patients (mean disease duration 5.7 +/- 4.1 SD years) was studied, in comparison with 70 healthy, age- and sex-matched controls. The electrocardiograms, chest radiographs and M-mode, 2-D and Doppler echocardiography were evaluated in a blind protocol. There were no significant differences in the prevalence of cardiac findings between the probands and the controls. It is concluded that cardiac involvement in Behçet's syndrome occurs only sporadically.

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Mitral and aortic regurgitation in Behcet's syndrome.

Abstract: A 35-year-old man with definite Behçet's disease developed acute mitral and aortic regurgitation. Valvular disease, we believed, was another manifestation of this disease. Cardiac involvement in Behçet's disease and the role of prednisone therapy are discussed.

Cited by 24 publications

References 8 publications

Diffuse Aortitis Complicating Behcet’s Disease Leading to Severe Aortic Regurgitation

Diffuse Aortitis Complicating Behcet’s Disease Leading to Severe Aortic Regurgitation

Left-Sided Cardiac Valvulitis in Tristetraprolin-Deficient Mice

M-mode, 2-D and Doppler echocardiographic study in 65 patients with Behçet's syndrome

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Mitral and aortic regurgitation in Behcet's syndrome.

Abstract: A 35-year-old man with definite Behçet's disease developed acute mitral and aortic regurgitation. Valvular disease, we believed, was another manifestation of this disease. Cardiac involvement in Behçet's disease and the role of prednisone therapy are discussed.

Cited by 24 publications

References 8 publications

Diffuse Aortitis Complicating Behcet&rsquo;s Disease Leading to Severe Aortic Regurgitation

Diffuse Aortitis Complicating Behcet&rsquo;s Disease Leading to Severe Aortic Regurgitation

Left-Sided Cardiac Valvulitis in Tristetraprolin-Deficient Mice

M-mode, 2-D and Doppler echocardiographic study in 65 patients with Behçet's syndrome

Contact Info

Product

Resources

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Diffuse Aortitis Complicating Behcet’s Disease Leading to Severe Aortic Regurgitation

Diffuse Aortitis Complicating Behcet’s Disease Leading to Severe Aortic Regurgitation