(-)-Mitorubrinol and Phthaldehydic Acids, New Metabolites of Penicillium vermiculatum DANG.

Abstract

Three new metabolites - (-)-mitorubrinol, 2-formyl-3,5-dihydroxy-4-methylbenzoic and 2-formyl-3,5-dihydroxy-4-hydroxymethylbenzoic acids - were isolated from the culture medium of Penicillium vermiculatum DANG. Hexane extract of the mycelium contained ergosterol and esters of fatty acids, linoleic, oleic and palmitic acids being the dominating ones.

Rubralactone, Rubralides A, B and C, and Rubramin Produced byPenicillium rubrum

“…[9][10][11] The formation of 2-4 may be envisaged as proceeding by oxidation, cyclization and methylation of 6 to give phthalide derivatives, and 5 may be envisaged to be formed by oxidation and methylation of 6.…”

“…10) Compound 6 belonging to phthalaldehydic acid is converted into the phthalide form in an aqueous solution. Thus, the formyl group at C-5 in the molecule of 2 and 3 might play an important role in the root growth.…”

Azaphilones: Chemistry and Biology

“…111 (−)-Lunatoic acid A (118) was isolated as a chlamydospore-like cell inducer from Cochliobolus lunata 113 and later as an inhibitor of GGTase I from Curvularia sp. 114 118 and rubiginosin C (119), bearing an aliphatic ester side chain instead of an aromatic group, have been reported. 112,115 The absolute configuration of 119 was established by CD spectroscopy.…”

A New Macrodiolide and Two New Polycyclic Chromones from the Fungus Penicillium sp. SCSIO041218

“…The identities of compounds 4 – 7 were established by comparison of their spectral data with those of the known compounds reported. They are 4-hydroxy-6-methoxy-5-methylphthalid ( 4 ) [12,13,14], methyl 2-(5-hydroxy-2,3,4-trimethylphenyl) propionate ( 5 ) [15], dehydromevalonic lactone ( 6 ) [16], ( R )-mevalonolactone ( 7 ) [17,18].…”