A New Macrodiolide and Two New Polycyclic Chromones from the Fungus Penicillium sp. SCSIO041218

Abstract

A new macrodiolide, mangrovlide A (1) and two new polycyclic chromones, penixanthones C (2) and D (3), as well as four other known compounds (4–7), have been isolated from the mangrove sediment derived fungus Penicillium sp. SCSIO041218, cultured in the 0.25% NaCl rice substrate. The structures of the new compounds were determined by analysis of the NMR and MS spectroscopic data. Compound 1 possesses a 10-membered macrodiolide unit, while 2 and 3 are chromones with an unprecedented 6/6/6/5 polycyclic skeleton. Compounds 1–7 were evaluated for their cytotoxicities, while all the compounds displayed weak or no activity.

Diversified Chaetoglobosins from the Marine-Derived Fungus Emericellopsis sp. SCSIO41202

“…In brief, chemical investigation of a culture of the mangrave sediment-derived fungus Emericellopsis sp. SCSIO41202 resulted in the isolation of two unreported cytochalasins, emeriglobosins A (1) and B (2), together with nine known analogues (3)(4)(5)(6)(7)(8)(9)(10)(11) and two known tetramic acid derivatives (12,13). Compound 5 exhibited significant inhibitory activity against PC-3 cells, with an IC 50 value of 2.32 µM.…”

Cryptic Metabolites from Marine-Derived Microorganisms Using OSMAC and Epigenetic Approaches

“…T. brevicompactum) isolated from a red algae in Palau is able to use halide ions from sodium halides in the medium to produce halogenated epidithiodiketopiperazine derivatives. Hence, supplementation of the freshwater medium with 3% NaI led to the isolation of a new iodinated derivative, iododithiobrevamide (35), which was not observed in the freshwater medium. Although Br derivatives have reportedly been produced by fermentation with inorganic bromides, it is rare to obtain an I derivative by fermentation with NaI [48].…”

“…Two new xanthone derivatives, penixanthones A (154) and B (155), were obtained from the 3% NaCl rice substrate [24]. In contrast, two new polycyclic chromones, penixanthones C (156) and D (157), and a new macrodiolide, mangrovlide A (158), were isolated from the culture on the 0.25% NaCl rice substrate [35]. Four new chromone derivatives (159-162) were also isolated from the 1% NaCl PDB substrate [45].…”

“…Compound 154 showed weak cytotoxicity against the H1975, MCF-7, K562, and HL7702 cell lines at a concentration of 30 µM [24]. Compounds 157 and 158 exhibited weak activity against K562, MCF-7, and Huh-7 cell lines, with IC 50 values of 55.2-67.5 µM [35]. Compounds 159-162 tested negative for anti-allergic bioactivity on IgE-mediated rat mast RBL-2H3 cells [45].…”

“…Enzyme inhibitors can also regulate NP production. Some chemicals such as metyrapone, tricyclazole and jasplakinolide can selectively inhibit the activity of monooxygenase and hydrolase in the biosynthetic pathway and promote the progress of other metabolic pathways [35,36].…”