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Cited by 331 publications
(318 citation statements)
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References 365 publications
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“…This chain was connected to C-3 by HMBC correlations of H-9 (d H 6.24) and H-10 (d H 6.67) to C-3. Thus, compound 1 was determined as a new azaphilone derivative belonging to sclerotiorin-type compounds (Gao et al, 2013). The stereochemistry of 1 was suggested by comparisons of experimental spectroscopic data with those of 2, which are discussed below.…”
Section: Structure Elucidationmentioning
confidence: 99%
“…This chain was connected to C-3 by HMBC correlations of H-9 (d H 6.24) and H-10 (d H 6.67) to C-3. Thus, compound 1 was determined as a new azaphilone derivative belonging to sclerotiorin-type compounds (Gao et al, 2013). The stereochemistry of 1 was suggested by comparisons of experimental spectroscopic data with those of 2, which are discussed below.…”
Section: Structure Elucidationmentioning
confidence: 99%
“…KCB12C078 was isolated from marine sediment in the Korea western sea region, Anmyeon Island, and chemical investigation of fungus led to the isolation of two new azaphilone derivatives, penidioxolanes A (1) and B (2), and four known azaphilones (3)(4)(5)(6). In this study, we describe the fermentation, isolation, and structural determination of these compounds, and their biological activity.…”
Section: -13mentioning
confidence: 99%
“…4 Among these various bioactive compounds, azaphilone family has been isolated from fungi belonging to 23 genera from 13 families, such as, Aspergillus, Penicillium, Chaetomium, Talaromyces, Pestalotiopsis, Phomopsis, Emericella, and Epicoccum, as well as Monascus and Hypoxylon sp.. Several azaphilones are unique to one species and constitute taxonomically important marker metabolites. 5,6 Azaphilone family are structurally diverse pigments, mostly secondary metabolites of fungal origin, and are highly oxygenated bicyclic rings showing various biological activities, including antimicrobial, antifungal, antiviral, antioxidant, cytotoxic, nematicidal and anti-inflammatory activities.…”
Section: Introductionmentioning
confidence: 99%
“…Azaphilone (Az) compounds are a group of fungal aromatic polyketides featuring an oxidized pyranoquinone bicyclic structure with a tertiary alcohol that is generally acylated. Az compounds display diverse biological activities that apparently involve interfering with specific protein-protein interactions (Gao et al 2013). Az is synthesized by a non-reducing fungal polyketide synthase with a reductive release domain (NR-fPKS-R) and its collaborating enzymes (Zabala et al 2012).…”
Section: Introductionmentioning
confidence: 99%