Mitochondrial Fatty Acid Transport System and its Relevance to Ovarian Function

doi:10.47277/jirb/6(1)/1

Cited by 3 publications

(1 citation statement)

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“…Two genes under positive selection in L. raddei were associated with different kinds of environmental adaptations-MRPS31, which is probably related to the ability to adapt to temperature gradients [57], and DSG2, which may be helpful for high-altitude adaptation [58] (Figure 4). Four genes were under weakening of negative selection (dN/dS < 1, but biased between species): two of them in L. raddei-GNL3L, which inhibits estrogen-related receptor activity [59], and DHRS4, which is involved in altering hormone-associated reproductive traits [60][61][62][63][64]; and two in L. gregalis-EFL1, which is associated with oogenesis and early embryogenesis [65], and CPT2, which is involved in oocyte maturation [66,67] and embryo developmental competence [68]. Interestingly, all three genes under selective pressure distinguished for L. gregalis are related to various aspects of oogenesis.…”

Section: Molecular Mechanisms Underlying Speciation Between Cryptic S...mentioning

confidence: 99%

Narrow-Headed Voles Species Complex (Cricetidae, Rodentia): Evidence for Species Differentiation Inferred from Transcriptome Data

et al. 2022

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The narrow-headed vole complex includes two cryptic species, Lasiopodomys raddei and L. gregalis, and three allopatrically-distributed lineages with obscure taxonomic ranks within the latter. Based on the RNA-seq data of 12 specimens, the current study aims to find the molecular mechanisms of intraspecies differentiation and, in particular, reproductive isolation between analyzed groups. According to the results of the GO-enrichment analysis, about a hundred biological processes associated with genes with contrasting SNPs for L. gregalis and L. raddei were identified. Among them, processes of interspecific interactions, defense responses, responses to external stimuli, and the perception of chemical stimuli and smell were identified, indicating the likely existence of pre-copulatory behavioral and physiological mechanisms that contribute to reproductive isolation between cryptic species. An evaluation of the ratio of non-synonymous substitutions to synonymous ones showed evidence of selection in L. raddei compared to L. gregalis for a large part of the analyzed genes. Among the analyzed genes, genes with both weakening and intensifying selection were found.

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Section: Molecular Mechanisms Underlying Speciation Between Cryptic S...mentioning

confidence: 99%

Narrow-Headed Voles Species Complex (Cricetidae, Rodentia): Evidence for Species Differentiation Inferred from Transcriptome Data

et al. 2022

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The decellularized ovary as a potential scaffold for maturation of preantral ovarian follicles of prepubertal mice

Alaee

Asadollahpour

Colagar

et al. 2021

Systems Biology in Reproductive Medicine

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An in-vitro analysis of L-Carnitine mediated rescue of TNF-? induced apoptosis in mice oocytes

Sharma¹,

Rana

Halder³

et al. 2022

IJCBR

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: Tumor necrosis factor-alpha (TNF-α) is a pro-inflammatory cytokine implicated in various physiological and pathological events. Carnitine is a quaternary amine which plays a significant role in fatty acid oxidation and is reported to produce antiapoptotic effects. Aim of this work was to study the effect of L-Carnitine (LC) on TNF-α induced apoptosis in mice oocytes. : Oocytes were isolated from super ovulated Swiss Albino mice and treated with different concentrations of TNF-α (0.1ng/ml, 1ng/ml, 10ng/ml, 100ng/ml) and LC (0.1mg/ml, 0.3mg/ml, 0.5mg/ml, 1.0 mg/ml). TUNEL Assay was done for the biochemical assessment of apoptosis.: Apoptotic indices with different doses of TNF-α (0.1ng/ml, 1ng/ml, 10ng/ml, 100 ng/ml) were 28.5%, 71.4%, 100%, 42.8% respectively. The concentration of TNF-α that produced the highest apoptotic index was 10ng/ml. LC alone in different doses (0.1mg/ml, 0.3mg/ml, 0.5mg/ml, 1.0 mg/ml) did not elicit any apoptotic signal. Further LC was added in different doses with 10ng/ml TNF-α to study the rate of apoptosis in mice oocytes. Apoptotic index with 10 ng/ml TNF-α and different doses of LC (0.1mg/ml, 0.3mg/ml, 0.5mg/ml, 1 mg/ml) were 25%, 37.5%, 50%, 62.5% respectively. The concentration of LC that reduced the apoptotic index to the maximum was 0.1mg/ml.: Present study could demonstrate the anti-apoptotic effect of LC against apoptotic effects of TNF-α in mice oocytes. The study presents preliminary data suggesting a possible therapeutic role of LC in inflammatory etiologies such as ovarian failure.

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Mitochondrial Fatty Acid Transport System and its Relevance to Ovarian Function

Cited by 3 publications

References 2 publications

Narrow-Headed Voles Species Complex (Cricetidae, Rodentia): Evidence for Species Differentiation Inferred from Transcriptome Data

Narrow-Headed Voles Species Complex (Cricetidae, Rodentia): Evidence for Species Differentiation Inferred from Transcriptome Data

The decellularized ovary as a potential scaffold for maturation of preantral ovarian follicles of prepubertal mice

An in-vitro analysis of L-Carnitine mediated rescue of TNF-? induced apoptosis in mice oocytes

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