2015
DOI: 10.18632/aging.100772 View full text |Buy / Rent full text
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Abstract: The process of skin wound healing is delayed or impaired in aging animals. To investigate the possible role of mitochondrial reactive oxygen species (mtROS) in cutaneous wound healing of aged mice, we have applied the mitochondria-targeted antioxidant SkQ1. The SkQ1 treatment resulted in accelerated resolution of the inflammatory phase, formation of granulation tissue, vascularization and epithelization of the wounds. The wounds of SkQ1-treated mice contained increased amount of myofibroblasts which produce ex… Show more

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“…SkQ1 also prevented TNF-induced decomposition of VE-cadherin-containing contacts, following an increase in the permeability of endothelial cell monolayer [12]. SkQ1 also inhibited apoptosis of endothelial cells induced by high doses of TNF [28].…”
Section: Discussionmentioning
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“…SkQ1 also prevented TNF-induced decomposition of VE-cadherin-containing contacts, following an increase in the permeability of endothelial cell monolayer [12]. SkQ1 also inhibited apoptosis of endothelial cells induced by high doses of TNF [28].…”
Section: Discussionmentioning
“…It seems attractive to develop a protocol that reduces its negative impact on proliferation. We cannot exclude that this side effect may be much stronger in the elderly, where proliferative and regenerative processes are retarded [63]. For example, it has been shown that in telomeraseknockout mice, the time necessary to recover renal function after I/R was longer than in agematched wild-type controls [64].…”
Section: Would Activation Of Autophagy Protect the Elderly?mentioning
“…And fibroblast dysfunction is linked to the overproduction of free ROS . Application of antioxidant or drugs with antioxidant properties could relieve the microenvironment of chronic inflammation, accelerate wound healing and alleviate scar formation on wounds . Similarly, classical traditional medicine, arsenic trioxide, could effectively inhibit the formation of rabbit ear scars through the overexpression of antioxidant genes …”
Section: Biotherapy For Inflammation In Hssmentioning