2017
DOI: 10.1155/2017/6408278
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Abstract: Oxidative stress is widely recognized as an important factor in the delayed wound healing in diabetes. However, the role of mitochondrial reactive oxygen species in this process is unknown. It was assumed that mitochondrial reactive oxygen species are involved in many wound-healing processes in both diabetic humans and animals. We have applied the mitochondria-targeted antioxidant 10-(6′-plastoquinonyl)decyltriphenylphosphonium (SkQ1) to explore the role of mitochondrial reactive oxygen species in the wound he… Show more

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Cited by 42 publications
(30 citation statements)
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“…One may thus hypothesize that excessive wound inflammation in diabetic patients may be improved by mitochondria-targeted antioxidants in compromised wound healing. This contention is supported by recent studies showing that antioxidant SkQ1 may improve dermal wound healing in genetically diabetic mice [ 62 ]. In these experiments, prevention of excessive mitochondrial ROS production by SkQ1 improved resolution of the inflammatory phase, simultaneously decreasing content of neutrophils and increasing content of macrophages [ 62 ].…”
Section: Redox Balance Modules Inflammation In the Healing Woundmentioning
confidence: 62%
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“…One may thus hypothesize that excessive wound inflammation in diabetic patients may be improved by mitochondria-targeted antioxidants in compromised wound healing. This contention is supported by recent studies showing that antioxidant SkQ1 may improve dermal wound healing in genetically diabetic mice [ 62 ]. In these experiments, prevention of excessive mitochondrial ROS production by SkQ1 improved resolution of the inflammatory phase, simultaneously decreasing content of neutrophils and increasing content of macrophages [ 62 ].…”
Section: Redox Balance Modules Inflammation In the Healing Woundmentioning
confidence: 62%
“…This contention is supported by recent studies showing that antioxidant SkQ1 may improve dermal wound healing in genetically diabetic mice [ 62 ]. In these experiments, prevention of excessive mitochondrial ROS production by SkQ1 improved resolution of the inflammatory phase, simultaneously decreasing content of neutrophils and increasing content of macrophages [ 62 ]. It seems reasonable to suggest that beneficial effects of SkQ1 on the inflamed wound could be attributed, at least in part, to the reduction of NLRP3 inflammasome activity, as these mitochondria-targeted ROS scavengers have been shown to decrease IL-1β and IL-18 production [ 63 , 64 ].…”
Section: Redox Balance Modules Inflammation In the Healing Woundmentioning
confidence: 62%
See 1 more Smart Citation
“…There is also evidence that a dysregulation of macrophage functions involves elevated production of ROS and disruption of Protein‐S‐glutathionylation signaling pathway (Short, Downs, Tavakoli, & Asmis, ). Recently, Demyanenko et al () showed that the excessive production of ROS is responsible for the inferior healing of diabetic wounds and that oral administration of mitochondria‐targeted antioxidant 10‐(6‐plastoquinonyl) decyltriphenylphosphonium (SkQ1) increased macrophage infiltration and improved inflammatory and regenerative phases of wound healing in the diabetes II mouse model. These data indicate that reprogramming of macrophage metabolism may be useful in manipulating the outcome of the wound‐healing process.…”
Section: Macrophage Mitochondria Respiration and Accelerated Wound mentioning
confidence: 99%
“…Antioxidants such as vitamin C, bilirubin ointment and SkO1 help to maintain a balance by reducing ROS levels at the wound site and promoting wound healing. [19][20][21] Chitosan (CS) or chitooligosaccharide (COS), a natural polysaccharide, can combine with superoxide free radicals, acting as a natural antioxidant, due to the abundance of free hydroxyl and amino groups. 22 It was reported that CS, acting as a protective agent against H 2 O 2 /FeSO 4 -induced cell death in the NT2 neural cell line, could show potential for the prevention and treatment of some central nervous system (CNS) diseases.…”
Section: Introductionmentioning
confidence: 99%