Mitochondria and plasma membrane dual-targeted chimeric peptide for single-agent synergistic photodynamic therapy

Cheng, Hong; Zheng, Rongrong; Fan, Guijuan; Fan, Jing-Hao; Zhao, Lin‐Ping; Jiang, Xueyan; Yang, Bin; Yu, Xiyong; Li, Shiying; Zhang, Xian‐Zheng

doi:10.1016/j.biomaterials.2018.10.005

Cited by 140 publications

(90 citation statements)

References 53 publications

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“…It is generally considered that the primary damage occurs at intracellular sites close to where ROS generates from the photosensitizer with light irradiation [ 32 ]. It has been previously reported that the photosensitizers localized in the cell membrane and mitochondria of cancer cells promoted the necrosis and apoptosis in PDT, respectively [ 33 , 34 , 35 , 36 , 37 ]. Due to the accumulation of AIE-M in both cell membranes and mitochondria of HeLa cells after 8 h uptake, it is possible to induce both necrosis and apoptosis after light irradiation.…”

Section: Resultsmentioning

confidence: 99%

Aggregation-Induced Emission (AIE) Polymeric Micelles for Imaging-Guided Photodynamic Cancer Therapy

2018

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Photodynamic therapy (PDT) is a noninvasive treatment for selectively killing malignant tumor cells. The photosensitizer is a necessary component of photodynamic nanomedicine. Many efforts have been made to develop new photosensitizers for efficient cancer photodynamic therapy. In this work, we report a novel nano photosensitizer, polymeric micelles (AIE-M) with aggregation induced emission characteristic, for photodynamic cancer therapy. AIE-M with sub-20 nm particle size is prepared by the self-assembly of salicylaldazine-incorporated amphiphilic polymer (AIE-1), which can produce reactive oxygen species (ROS) with light irradiation in solution. After uptake by cancer cells, AIE-M can specially sojourn in plasma membranes of cancer cells at the early stage and predominantly accumulate in the mitochondria of cancer cell at the late stage. The phototoxicity of AIE-M, resulting from the generation of intracellular ROS with light irradiation, can efficiently cause cancer cells death by apoptosis and necrosis. The advantages of AIE-M as a nano photosensitizer include the small size, highly colloidal stability in the process of preparation and storage, and high cell penetration. The ultra-low Critical Micelle Concentration (CMC) of AIE-1, negligible dark toxicity and super phototoxicity of AIE-M suggest its promising potential for image-guided PDT.

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Section: Resultsmentioning

confidence: 99%

Aggregation-Induced Emission (AIE) Polymeric Micelles for Imaging-Guided Photodynamic Cancer Therapy

2018

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“…However, in the supermolecular structure of BTZ-NP in D 2 O, none of the BTZ peaks was detectable. It was clear that the peaks corresponding to (27,26,28,29,21) and (17,19) were absent in the 1 H-NMR spectra of BTZ-NP in D 2 O. In contrast, the typical peaks of PVP (2, 3, 5, 4, 1) were clearly observed in the 1 H-NMR spectra of BTZ-NP in D 2 O and, the TA peaks (13,12,11) were also detectable.…”

Section: The Supermolecule Formation Mechanisms Researchmentioning

confidence: 99%

“…The drug distribution in the tumor of the BTZ-NP group was statistically higher than the BTZ solution group. The superior enrichment of the BTZ-NP in the malignant tissue was ascribed to the EPR effects of the nano-drug delivery systems and, would promise profound therapeutic effects [16][17][18][19][20][21][22][23][24].…”

Section: In Vivo Distribution Of the Btz-npmentioning

confidence: 99%

Preparation, characterization and in vitro–in vivo evaluation of bortezomib supermolecular aggregation nanovehicles

et al. 2020

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Backgrounds: Intolerable toxicity and unsatisfactory therapeutic effects are still big problems retarding the use of chemotherapy against cancer. Nano-drug delivery system promised a lot in increasing the patients' compliance and therapeutic efficacy. As a unique nano-carrier, supermolecular aggregation nanovehicle has attracted increasing interests due to the following advantages: announcing drug loading efficacy, pronouncing in vivo performance and simplified production process. Methods: In this study, the supermolecular aggregation nanovehicle of bortezomib (BTZ) was prepared to treat breast cancer. Results: Although many supermolecular nanovehicles are inclined to disintegrate due to the weak intermolecular interactions among the components, the BTZ supermolecules are satisfying stable. To shed light on the reasons behind this, the forces driving the formation of the nanovehicles were detailed investigated. In other words, the interactions among BTZ and other two components were studied to characterize the nanovehicles and ensure its stability. Conclusions: Due to the promising tumor targeting ability of the BTZ nanovehicles, the supermolecule displayed promising tumor curing effects and negligible systemic toxicity.

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“…As we all know, reactive oxygen species (ROS)‐initiated apoptosis is a widely used tumor treatment strategy . The Fenton‐like reaction between hydroperoxide and catalytic Fe 2+ has been documented to generate toxic 1 O 2 .…”

Section: Resultsmentioning

confidence: 99%

Unsaturation‐Dependent Nanostructures Self‐Assembled from Oligopeptide Amphiphiles Capable of Generating Singlet Oxygen

et al. 2019

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We report here on three oligopeptide amphiphiles (OPA1-3) with different unsaturated double bonds, which self-assemble into shape-specific nanostructures. It was found that OPA1 with saturated hydrophobic tail self-assembled into conventional cylindrical nanofibers, while the unsaturated OPA2-3 molecules self-organized into helical nanoarchitectures. Due to the different double bond numbers in hydrophobic tails of OPA2-3, the helical pitch and width of their self-assemblies varied. Specially, linoleic acid-bearing OPA3 could be oxidized by lipoxidase to create hydroperoxide-containing OPA4, which further generated singlet oxygen ( 1 O 2 ) in the presence of catalytic iron (II) ion. The established system may provide a self-deliverable nanoplatform for 1 O 2 -mediated cancer treatment. Results and DiscussionFirstly, three oligopeptide amphiphiles (OPA1-3) were synthesized manually by Fmoc-based solid phase synthesis. To obtain OPA4, OPA3 with linolic acid group was oxidized by lipoxidase. [20] The molecular weights of OPA1-4 were measured by matrix-assisted laser desorption/ionization time of flight mass spectrometry (MALDI-TOF-MS) ( Figure S1, Supporting [a] J.

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Mitochondria and plasma membrane dual-targeted chimeric peptide for single-agent synergistic photodynamic therapy

Cited by 140 publications

References 53 publications

Aggregation-Induced Emission (AIE) Polymeric Micelles for Imaging-Guided Photodynamic Cancer Therapy

Aggregation-Induced Emission (AIE) Polymeric Micelles for Imaging-Guided Photodynamic Cancer Therapy

Preparation, characterization and in vitro–in vivo evaluation of bortezomib supermolecular aggregation nanovehicles

Unsaturation‐Dependent Nanostructures Self‐Assembled from Oligopeptide Amphiphiles Capable of Generating Singlet Oxygen

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