Mitigating impact of <scp>l</scp>-carnitine against dimethoate induction of hepatic and testicular genotoxicity in rats: the role of oxidative stress

Zakzok, Fatma B.; Hegazy, Hanaa; Yosef, T.A.; Gomaa, Ghada M.

doi:10.1080/15569543.2018.1522645

Cited by 4 publications

(4 citation statements)

References 49 publications

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“…On the other hand, several studies have suggested a protective effect of LC on DNA damage in several test organisms, but at lower concentrations than those tested in the current experiment (200 mg kg -1 ) (Alzahrani, 2011;Shadboorestan et al, 2015;Zakzok et al, 2018). Therefore, we hypothesized that higher concentrations of LC could lead to genotoxic effects in exposed organisms.…”

Section: Discussionmentioning

confidence: 64%

Zootechnical performance, degree of steatosis and the genotoxic potential in yellowtail tetra Astyanax lacustris fed with different levels of L-carnitine

Martins

Silva

Nascimento

et al. 2023

Arq. Bras. Med. Vet. Zootec.

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L-carnitine perform a major role in transporting long-chain fatty acids into the mitochondria, where they are oxidized. It has been used in animal diets to decrease fat and increase muscle protein. The aim of this study was to evaluate the zootechnical performance, degree of steatosis in the liver, and genotoxic potential in Astyanax lacustris fed with different levels of L-carnitine (LC). Yellowtail tetra juveniles (n = 140) were distributed in 20 tanks of 70 L, with seven fish in each, in a water recirculation system with controlled temperature (27±0.1⁰C). The treatments with different levels of L-carnitine supplementation were: 0 (control), 250, 500, 750, and 1000 mg of LC per kg of food. The diets were provided twice a day for 60 days. The results showed that the different levels of LC did not affect (P>0.05) weight gain, survival, viscerosomatic index, and the liver hepatocytes showed a normal appearance. However, the use of LC supplementation showed genotoxic potential with a significant difference (P<0.05) for cell alterations when compared to the control at concentrations above 500mg kg-1.

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Section: Discussionmentioning

confidence: 64%

Zootechnical performance, degree of steatosis and the genotoxic potential in yellowtail tetra Astyanax lacustris fed with different levels of L-carnitine

Martins

Silva

Nascimento

et al. 2023

Arq. Bras. Med. Vet. Zootec.

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“…Many in vitro studies [22][23][24][25][26][27][28][29], and in vivo studies of animals [30][31][32][33][34][35][36][37][38][39][40][41][42][43][44][45][46][47] and humans [48][49][50][51][52][53][54][55][56][57][58][59] have reported different beneficial functions for carnitine. In the following, the main activities observed are reported.…”

Section: An Updated Shot Of Beneficial Properties: In Vitro and In Vivo Studiesmentioning

confidence: 99%

“…[45] In-animal model Antioxidant effect l-carnitine (200 mg/kg BW) for 11 weeks prevented dimethoate toxicity in rats. [46] In-animal model Antioxidant effect…”

Section: Immunostimulatory and Radioprotective Rolementioning

confidence: 99%

The Nutraceutical Value of Carnitine and Its Use in Dietary Supplements

Durazzo¹,

Lucarini²,

Nazhand

et al. 2020

Molecules

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Carnitine can be considered a conditionally essential nutrient for its importance in human physiology. This paper provides an updated picture of the main features of carnitine outlining its interest and possible use. Particular attention has been addressed to its beneficial properties, exploiting carnitine’s properties and possible use by considering the main in vitro, in animal, and human studies. Moreover, the main aspects of carnitine-based dietary supplements have been indicated and defined with reference to their possible beneficial health properties.

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“…Newer sources of dietary antioxidants are being researched experimentally for their nephroprotection potential and are being increasingly used clinically for relieving stress of oxidant excess in patients with kidney impairment [19]. Previous research has shown that natural compounds have potential to protect against DM induced oxidative stress driven toxicity affecting various organs [20][21][22]. Speci cally, workers have demonstrated that intake of herbal extracts shields from oxidative damage led nephrotoxicity created by DM [23] and antioxidants are also bene cial in reducing uoride toxicity [24].…”

Section: Introductionmentioning

confidence: 99%

Oxidative renal damage induced by fluoride and dimethoate and its mitigation by Zingiber officinale in Wistar rats

Sharma

Verma

Sood

et al. 2022

Preprint

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Simultaneous exposure of dimethoate (DM) and fluoride (F−) is a natural phenomenon which may insidiously impact functioning of various organs including kidney. Zingiber officinale (ZO) is harbours excellent natural antioxidant properties. Therefore, the present investigation was aimed to determine the potential of ZO in alleviating renal oxidative damage induced by DM and F− alone and by their concurrent exposure in Wistar rats. Subacute toxicity study was conducted on fifty four Wistar rats randomly allocated to nine groups with six rats in each. Following sub-acute exposure of either F− or DM a significant rise in blood urea nitrogen, creatinine and uric acid along with a significant declined in plasma levels of reduced glutathione and nitric oxide occurred. Significantly declined total antioxidant status, total thiols, catalase, superoxide dismutase, glutathione peroxidase, aryl esterase and acetylcholinesterase in renal tissue with increased levels of lipid and protein peroxidation were recorded alongside pathological alterations in renal tissue of toxicant exposed rats as compared to control. However, more severe changes were observed in levels of the above biomarkers and renal histoarchitecture on co-administration of both the toxicants indicating enhanced toxicity. Concurrent exposures of ZO extract along with either or both the toxicants led to significant restoration of activities of the antioxidant apparatus, biochemical profile of kidney and renal histology. Hence, repeated administration of ZO extract alongside individual as well as dual toxicant treatment caused amelioration of oxidative damage, renal biomarkers and histopathological alterations in renal tissue of Wistar rats.

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Mitigating impact of l-carnitine against dimethoate induction of hepatic and testicular genotoxicity in rats: the role of oxidative stress

Cited by 4 publications

References 49 publications

Zootechnical performance, degree of steatosis and the genotoxic potential in yellowtail tetra Astyanax lacustris fed with different levels of L-carnitine

Zootechnical performance, degree of steatosis and the genotoxic potential in yellowtail tetra Astyanax lacustris fed with different levels of L-carnitine

The Nutraceutical Value of Carnitine and Its Use in Dietary Supplements

Oxidative renal damage induced by fluoride and dimethoate and its mitigation by Zingiber officinale in Wistar rats

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