2007
DOI: 10.1586/17469872.2.1.31
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Misuse and abuse of topical steroids: implications

Abstract: Topical steroids, having revolutionized dermatotherapy over several decades, remain the mainstay of treatment for steroid-responsive inflammatory dermatoses worldwide. Challenges, nevertheless, abound on the usage of topical steroids, particularly with their inappropriate application. Several steps and improved formulations are constantly evolving in the scientific world, aimed at addressing most of the associated adverse events. However, until the dawn of the 'ideal topical steroid', the implications of appli… Show more

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Cited by 5 publications
(5 citation statements)
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“…As the development of IAD is driven by an underlying inflammatory process, the use of products containing anti-inflammatory properties is also favored. Topical steroidal products such as hydrocortisone are frequently prescribed for its anti-inflammatory effects on various dermatoses such as IAD [39]. The application of a thick layer of skin protectants is consistently advocated in clinical guidelines, and care providers are cautioned against total removal of leave-on skin products at every diaper change.…”
Section: Skin Care Productsmentioning
confidence: 99%
“…As the development of IAD is driven by an underlying inflammatory process, the use of products containing anti-inflammatory properties is also favored. Topical steroidal products such as hydrocortisone are frequently prescribed for its anti-inflammatory effects on various dermatoses such as IAD [39]. The application of a thick layer of skin protectants is consistently advocated in clinical guidelines, and care providers are cautioned against total removal of leave-on skin products at every diaper change.…”
Section: Skin Care Productsmentioning
confidence: 99%
“…TCS reduce inflammation and pruritus [4,9,16,20,49,62] by acting on various immune cells to disrupt antigen processing and presentation and by suppressing the release of proinflammatory cytokines [4,69,70]. They are frequently prescribed to treat the acute and chronic signs of AD in adults and children [4,49].…”
Section: Topical Corticosteroidsmentioning
confidence: 99%
“…For acute flares, TCS are often used daily for up to several weeks, and proactive use (once to twice weekly) is recommended for chronic relapsing areas [4]. Potential adverse effects of long-term treatment include striae, folliculitis, acne-like eruptions, focal hypertrichosis, allergic contact dermatitis, glaucoma, papilloedema and telangiectasia [4,66,69]. Long-term TCS treatment is associated with an increase in the risk of tachyphylaxis to TCS, and hypothalamic-pituitary-adrenal axis suppression, Cushing syndrome, growth retardation, glucose intolerance, peptic ulcer disease, neuropsychiatric manifestations and other adverse effects [4,66,69].…”
Section: Topical Corticosteroidsmentioning
confidence: 99%
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“…Topical corticosteroids (TCs) are the mainstay of dermato-therapeutics. [1] Though they were introduced in 1952, earliest reports of TC dependence or addiction started appearing shortly thereafter within next two decades by 1970s. [23] Due to wide availability of these TCs, there is rampant, dismal, and disturbing misuse of topical steroid on face in India which results in severe cutaneous damage characterized by erythema, monomorphic acne, steroid atrophy, steroid rosacea, telangiectasia, perioral dermatitis, striae, and severe addiction to the TC.…”
Section: Introductionmentioning
confidence: 99%