Misindentification of<i>Mycobacterium kumamotonense</i>as<i>M. tuberculosis</i>

Rodríguez-Aranda, Almudena; Jiménez, María Soledad; Yubero, Jesús; Chaves, F.J.; García, Rafael Rubio; Palenque, Elia; García, María Jesús García; Menéndez, M. Carmen

doi:10.3201/eid1607.091913

Cited by 17 publications

(11 citation statements)

References 7 publications

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“…Other rare NTM species isolated from patients in the present study ( M. lentiflavum , M. mageritense , M. chimaera and M. xenopi ) may also cause lung diseases [ 16 , 18 , 19 , 23 ]. However, yet other rare NTM isolated from these patients, such as M. kumamotonense and M. celatum , have generally been considered to be misidentifications or a result of culture contamination, and are thus deemed to be clinically non-pathogenic organisms [ 24 , 25 ].…”

Section: Discussionmentioning

confidence: 99%

Frequency and clinical implications of the isolation of rare nontuberculous mycobacteria

et al. 2015

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BackgroundTo date, more than 125 species of nontuberculous mycobacteria (NTM) have been identified. In this study, we investigated the frequency and clinical implication of the rarely isolated NTM from respiratory specimens.MethodsPatients with NTM isolated from their respiratory specimens between July 1, 2010 and June 31, 2012 were screened for inclusion. Rare NTM were defined as those NTM not falling within the group of eight NTM species commonly identified at our institution: Mycobacterium avium, M. intracellulare, M. abscessus, M. massiliense, M. fortuitum, M. kansasii, M. gordonae, and M. peregrinum. Clinical, radiographic and microbiological data from patients with rare NTM were reviewed and analyzed.ResultsDuring the study period, 73 rare NTM were isolated from the respiratory specimens of 68 patients. Among these, M. conceptionense was the most common (nine patients, 12.3%). The median age of the 68 patients with rare NTM was 68 years, while 39 of the patients were male. Rare NTM were isolated only once in majority of patient (64 patients, 94.1%). Among the four patients from whom rare NTM were isolated two or more times, only two showed radiographic aggravation caused by rare NTM during the follow-up period.ConclusionsMost of the rarely identified NTM species were isolated from respiratory specimens only once per patient, without concomitant clinical aggravation. Clinicians could therefore observe such patients closely without invasive work-ups or treatment, provided the patients do not have decreased host immunity towards mycobacteria.

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Section: Discussionmentioning

confidence: 99%

Frequency and clinical implications of the isolation of rare nontuberculous mycobacteria

et al. 2015

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“…The incidence of MNT disease is high in patients suffering from immunosuppression, connective tissue diseases, diabetes mellitus or using steroid corticosteroids. Mortality is significantly increased in patients older than 65 years, of the female gender and co-infection with HIV / AIDS [12,13].…”

Section: Discussionmentioning

confidence: 99%

Mycobacterium kumamotonense in the cervical region in an immunocompetent patient, clinical case report in Mexico

Solís

González-Villa²,

Ramírez–González³

et al. 2019

J Infect Dev Ctries

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“…The un-complete recover of the patient prompted for a further characterization of the isolate by using standard microbiological procedures. These procedures allowed the identification of the isolate as Mycobacterium kumamotonense [3].…”

Section: Introductionmentioning

confidence: 99%

“…With the aim of clarify the previous result using AccuProbe, other two commercial probes were applied, however, one of them again misidentified the bacteria as MTBC. The three commercial probes applied have different genome regions as targets, all them belonging to the mycobacterial ribosomal RNA operon rrn [3].…”

Section: Introductionmentioning

confidence: 99%

Mycobacterium kumamotonense, another Member of the Mycobacterium terrae Complex Unusually Carrying Two Copies of the Ribosomal RNA Operon

Menéndez¹

2014

Mycobact Dis

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The novel slow-grower Mycobacterium kumamotonense was previously misidentified as Mycobacterium tuberculosis complex using commercial probes. Similarly to other slow-growers that cross-react with the tubercle bacilli using commercial probes, M. kumamotonense is carrying two copies of the ribosomal RNA operon (rrn) per genome. Analysis of the corresponding rrn regions allowed the identification of sequences putatively involved in that cross-reactivity.

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Misindentification ofMycobacterium kumamotonenseasM. tuberculosis

Cited by 17 publications

References 7 publications

Frequency and clinical implications of the isolation of rare nontuberculous mycobacteria

Frequency and clinical implications of the isolation of rare nontuberculous mycobacteria

Mycobacterium kumamotonense in the cervical region in an immunocompetent patient, clinical case report in Mexico

Mycobacterium kumamotonense, another Member of the Mycobacterium terrae Complex Unusually Carrying Two Copies of the Ribosomal RNA Operon

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