Miscibility study of carrageenan blends and evaluation of their effectiveness as sustained release carriers

Nanaki, Stavroula; Karavas, Evangelos; Kalantzi, Lida; Bikiaris, Dimitrios N.

doi:10.1016/j.carbpol.2009.10.067

Cited by 72 publications

(46 citation statements)

References 46 publications

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“…Carrageenans also present interesting biological properties, including antioxidant, anticoagulant, antitumor, and immunomodulatory activities (Campo et al 2009;Wijesekara et al 2011; Barahona et al 2011Barahona et al , 2012De Araujo et al 2013;Prajapati et al 2014). Recently, studies on the application of carrageenans in drug delivery systems have gained much interest (Nanaki et al 2010;Rana et al 2011;Li et al 2013Li et al , 2014. On the other hand, copolymerization of carrageenans with vinyl monomers produces graft copolymers with new properties and applications Meena et al 2006;Pourjavadi et al 2008;Hosseinzadeh 2009;Mishra et al 2010;Sand et al 2012;Yadav et al 2012;Verma et al 2014).…”

Section: Introductionmentioning

confidence: 95%

Carrageenans from nuclear phases of subantartic Mazzaella laminarioides (Gigartinales, Rhodophyta) and graft copolymerization of alkali-modified carrageenan with acrylamide

et al. 2015

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Aqueous extraction of cystocarpic, tetrasporic, and vegetative individuals of Mazzaella laminariodes collected in the Magellan Ecoregion, Southern Chile, afforded sulfated galactans. Analysis by Fourier transform infrared spectroscopy (FT-IR) and by 1 H and 13 C NMR spectroscopy indicated that purified extracts from cystocarpic (CP) and vegetative individuals (VP) were mixtures of κ/ι-type carrageenans and their precursors μ-and ν-carrageenans, whereas the aqueous extract from tetrasporic individuals was a λ-type carrageenan. Alkaline treatment of CP and VP polysaccharides produced modified polysaccharides with lower content of sulfate groups and with a concomitant increase of 3,6-anhydrogalactose content; analysis by 2D 1 H and 13 C NMR indicated the presence of hybrid κ-ι-carrageenans. Copolymerization of alkalitreated CP carrageenan with acrylamide was achieved by using ceric ammonium nitrate as the initiator; studies by NMR spectroscopy indicated grafting of polyacrylamide at position C-6 of β-galactopyranosyl residues. Reaction of modified CP with acrylamide assisted by microwave irradiation in the presence of ammonium persulfate afforded a copolymer grafted at position C-2 of β-galactopyranosyl residues.

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Section: Introductionmentioning

confidence: 95%

Carrageenans from nuclear phases of subantartic Mazzaella laminarioides (Gigartinales, Rhodophyta) and graft copolymerization of alkali-modified carrageenan with acrylamide

et al. 2015

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“…in the composition and degree of sulphation (Necas & Bartosikova, 2013). The actual content of the sulphate residue (by weight) may vary between 15 and 40% for the various carrageenan types (Nanaki, Karavas, Kalantzi, & Bikiaris, 2010). Their applications include experimental medicine, pharmaceutical formulations and are well established as gelling, stabilising and thickening agents for food, cosmetics and industrial uses (Necas & Bartosikova, 2013).…”

Section: Introductionmentioning

confidence: 99%

“…Their applications include experimental medicine, pharmaceutical formulations and are well established as gelling, stabilising and thickening agents for food, cosmetics and industrial uses (Necas & Bartosikova, 2013). CARs are biocompatible and biodegradable polysaccharides with low toxicity and well documented properties of controlling and extending release of various drug substances (Nanaki et al, 2010) as well as improving apparent solubility and dissolution rates of poorly soluble actives (Dai, Dong, & Song, 2007). In addition, studies have shown that CARs have a high capacity to interact with proteins due to their strong ionic nature (Malafaya, Silva, & Reis, 2007) and form excellent matrices for predictable synthesis of magnetite nanoparticles (Daniel-da-Silva et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

Self-assembled carrageenan/protamine polyelectrolyte nanoplexes—Investigation of critical parameters governing their formation and characteristics

Dul

Paluch

Kelly

et al. 2015

Carbohydrate Polymers

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The aim of this work was to investigate the feasibility of cross-linker free polyelectrolyte 1 complex formation at the nanoscale between carrageenan (CAR) and protamine (PROT). 2 The properties of CAR/PROT nanoparticles (NPs) were dependent on the carrageenan type: 3 kappa (KC), iota (IC) and lambda (LC), concentration of components, addition of divalent 4 cations, weight mixing ratio (WMR) of constituents and mode of component addition. In the 5 case of 0.1% w/v solutions, IC-based NPs had the smallest particle sizes (100-150 nm) and 6 low polydispersity indices (0.1-0.4). A decrease in the solution concentration from 0.1% to 7 0.05% w/v enabled the formation of KC/PROT NPs. All carrageenans exhibited the ability to 8 form NPs with surface charge ranging from -190 to 40 mV. The inclusion of divalent cations 9 caused an increase in the particle size and zeta potential. Infrared analysis confirmed the 10 presence of a complex between CAR and PROT and showed that IC chains undergo 11 structural changes when forming NPs. Colloidal stability of NPs was related to the initial 12 surface charge of particles and was time-and pH-dependent. IC was found to be the most 13 suitable type of CAR when forming nanoplexes with PROT. 14 15

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“…Therefore, addition of locust bean to the IPEC enhanced IPEC delivery to follow zeroorder release kinetics. This is corroborated by a study indicating that polymer blending can modulate drug release to follow zero-order kinetics (17).…”

Section: In Vitro Drug Release Studiesmentioning

confidence: 55%

“…For instance, hydrophilicity of polycaprolactone has been enhanced by blending with a polysaccharide, chitosan (13). Polymer blending has been employed to increase rate of degradation, control water content thereby manipulating permeability (8,14); control and extend drug release (15,16); achieve zero-order kinetics (17) moderate swelling (15,18), modify protein delivery (19) and modulate porosity (20). The popular techniques of polymer blending include melting and aqueous blending (21).…”

Section: Introductionmentioning

confidence: 99%

A Co-blended Locust Bean Gum and Polymethacrylate-NaCMC Matrix to Achieve Zero-Order Release via Hydro-Erosive Modulation

et al. 2015

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Abstract. Locust bean gum (LBG) was blended with a cellulose/methacrylate-based interpolyelectrolyte complex (IPEC) to assess the hydro-erosive influence of addition of a polysaccharide on the disposition and drug delivery properties inherent to IPEC matrix. The addition of LBG modulated the drug (levodopa) release characteristics of the IPEC by reducing excessive swelling and preventing bulk erosion. After 8 h in pH 4.5 dissolution medium, gravimetric analysis established that IPEC tablet matrix eroded by 30% of the initial weight due to bulk erosion while LBG-blended IPEC (LBG-b-IPEC) demonstrated surface erosion accounting to 62% of initial weight (596→226.8 mg). Mathematical modeling of the drug release data depicted a transformation from non-Fickian mechanism (IPEC matrices) to zero-order drug release pattern (LBG-b-IPEC matrices) with the linearity of release profile being close to 1 (R 2 =0.99). Physicochemical characterizations employing Fourier transform infrared spectroscopy (FTIR) and differential scanning calorimetry (DSC) explicated that LBG interacted with IPEC by its hydrophilic groups associating with the existing water-holding bodies of IPEC to produce compact matrices. The lattice atomistic modeling elucidated that LBG acted as a linker with the formation of intra-and intermolecular hydrogen bonds generating a highly stabilized polysaccharide-polyelectrolytic structure which influenced the improved properties observed.

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Miscibility study of carrageenan blends and evaluation of their effectiveness as sustained release carriers

Cited by 72 publications

References 46 publications

Carrageenans from nuclear phases of subantartic Mazzaella laminarioides (Gigartinales, Rhodophyta) and graft copolymerization of alkali-modified carrageenan with acrylamide

Carrageenans from nuclear phases of subantartic Mazzaella laminarioides (Gigartinales, Rhodophyta) and graft copolymerization of alkali-modified carrageenan with acrylamide

Self-assembled carrageenan/protamine polyelectrolyte nanoplexes—Investigation of critical parameters governing their formation and characteristics

A Co-blended Locust Bean Gum and Polymethacrylate-NaCMC Matrix to Achieve Zero-Order Release via Hydro-Erosive Modulation

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