A Co-blended Locust Bean Gum and Polymethacrylate-NaCMC Matrix to Achieve Zero-Order Release via Hydro-Erosive Modulation

Abstract

Abstract. Locust bean gum (LBG) was blended with a cellulose/methacrylate-based interpolyelectrolyte complex (IPEC) to assess the hydro-erosive influence of addition of a polysaccharide on the disposition and drug delivery properties inherent to IPEC matrix. The addition of LBG modulated the drug (levodopa) release characteristics of the IPEC by reducing excessive swelling and preventing bulk erosion. After 8 h in pH 4.5 dissolution medium, gravimetric analysis established that IPEC tablet matrix eroded by 30% of the initial weight due to bulk erosion while LBG-blended IPEC (LBG-b-IPEC) demonstrated surface erosion accounting to 62% of initial weight (596→226.8 mg). Mathematical modeling of the drug release data depicted a transformation from non-Fickian mechanism (IPEC matrices) to zero-order drug release pattern (LBG-b-IPEC matrices) with the linearity of release profile being close to 1 (R 2 =0.99). Physicochemical characterizations employing Fourier transform infrared spectroscopy (FTIR) and differential scanning calorimetry (DSC) explicated that LBG interacted with IPEC by its hydrophilic groups associating with the existing water-holding bodies of IPEC to produce compact matrices. The lattice atomistic modeling elucidated that LBG acted as a linker with the formation of intra-and intermolecular hydrogen bonds generating a highly stabilized polysaccharide-polyelectrolytic structure which influenced the improved properties observed.

In silico analytico‐mathematical interpretation of biopolymeric assemblies: Quantification of energy surfaces and molecular attributes via atomistic simulations

“…This way the authors managed to deduce the polyelectrolyte complexation into four different stages as follows: (a) initial stage: the presence of intramolecular bonding within NaCMC and the absence of any intermolecular interactions with Eudragit E100; (b) intermediate stage: first evidence of formation of intermolecular bonds with a relative decrease in NaCMC intermolecular interactions; (c) breaking point: formation of complex structure with thickening of the reaction medium due to network entanglement; and (d) final product: a homogenous polyelectrolyte complex formation with a perfect balance of intramolecular and intermolecular interactions. The in silico results so obtained were well corroborated with the in vitro rheological analyses and the stages were assigned at 30 s, 1 hr, stopping of magnetic bar movement, and final homogenous product . The formation of NaCMC‐Eudragit E100 I.E.…”

“…9 In product. [10][11][12] The formation of NaCMC-Eudragit E100 I.E. was accompanied by dense H-bonding and van der Waals interactions.…”

Green approach for fabrication of chitosan‐neem gum polyelectrolyte stabilized penta and hexagonal nanoparticles and in‐vitro cytotoxic potential toward breast cancer (MCF‐7) cells

“…It is a commonly used cationic polymer for the preparation of PEC 9,10 . Various polysaccharides such as guar gum, 11 gum acacia, 12 locust bean gum, 13 pectin, 14 and so on have been used as an anionic polymer for the PEC formation. Below pH 6.5, the amino groups of Ch become ionized and net positive charge appears over chitosan structure.…”

“…It is a commonly used cationic polymer for the preparation of PEC. 9,10 Various polysaccharides such as guar gum, 11 gum acacia, 12 locust bean gum, 13 pectin, 14 and so on have been used as an anionic polymer for the PEC formation.…”

Synthesis and characterization of Locust Bean Gum derivatives and their application in the production of nanoparticles

“…Importantly, this is the value considered by ISO 10993-5 (ISO, 2009) as the level below which a toxic effect is assumed to occur. Although not directly proposed herein as matrix material per se, unmodified LBG was also tested, because its application in drug delivery has been reported, in many occasions addressing oral delivery strategies (Colombo et al, 1990;Conte & Maggi, 1996;Coviello, Alhaique, Dorigo, Matricardi & Grassi, 2007;Dey, Sa & Maiti, 2015; Jana, Gandhi, Sheet & Sen, 2015;Malik, Arora & Singh, 2011a;Malik, Arora & Singh, 2011b;Ngwuluka, Choonara, Kumar, du Toit, Modi & Pillay, 2015;Sandolo, Coviello, Matricardi & Alhaique, 2007;Sujja-areevath, Munday, Cox & Khan, 1998;Syed, Mangamoori & Rao, 2010;Tobyn, Staniforth, Baichwal & McCall, 1996), but data on its effect on epithelial cells are not available in the literature. Moreover, a comparison between bulk LBG and purified LBG was performed, revealing no significant differences, which indicates an absence of effect of the purification process in the cytotoxic profile of the material.…”