Misaligned Feeding May Aggravate Pain by Disruption of Sleep–Awake Rhythm

Xu, Fengqin; Zhao, Xin; Liu, Huan; Shao, Xueming; Chu, Shuaishuai; Gong, Xiangdan; Ma, Zhengliang; Gu, Xiaoping

doi:10.1213/ane.0000000000002727

Cited by 10 publications

(4 citation statements)

References 26 publications

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“… 44 In a study of mice, exposure to sustained misaligned-time feeding led to an altered rest-activity rhythm and greater sensitivity to pain, with recovery after the administration of melatonin. 45 It is also postulated that painful conditions would occur with a certain rhythm, probably due to the homeostatic sleep drive and circadian rhythms modulating pain neural pathways. 46 …”

Section: Discussionmentioning

confidence: 99%

Changes in the rest-activity rhythm in migraine patients are associated with anxiety symptoms

David¹,

Mattos²,

Souto³

et al. 2022

Brazilian Journal of Psychiatry

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Objective: To characterize rest-activity rhythm in chronic migraine (CM) and to investigate the relationship between this rhythm and depressive and anxiety symptoms in patients with CM. Methods: This was a study of adults aged 20 to 40 years. The rest-activity rhythm of patients with CM (n=23) and non-headache controls (NH, n=23) was assessed by actigraphy for 15 days, and they completed the following assessments: Visual Analogue Scale for pain intensity; Headache Diary; Headache Impact Test-6; Morningness-Eveningness Questionnaire; Pittsburgh Sleep Quality Index; Epworth Sleepiness Scale; Beck Depression Inventory; and State-Trait Anxiety Inventory. Results: Patients with CM showed less activity over 24 hours and more fragmented sleep. Reduced interdaily stability of the rest-activity rhythm was observed, with less robustness of this rhythm in the CM group. Multiple linear regressions revealed a significant association between the rest-activity rhythm and trait anxiety variables in patients with CM, specifically regarding the relative amplitude of the cycle, activity throughout 24 hours and during sleep, and robustness of the rest-activity rhythm. Conclusions: Our findings provide evidence that the robustness of the rest-activity rhythm, activity throughout 24 hours, and sleep fragmentation are associated with trait anxiety in patients with CM. Clinical trial registration: Brazilian Clinical Trials Registry (registration number: RBR-4M5J4S).

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Section: Discussionmentioning

confidence: 99%

Changes in the rest-activity rhythm in migraine patients are associated with anxiety symptoms

David¹,

Mattos²,

Souto³

et al. 2022

Brazilian Journal of Psychiatry

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“…Another study similarly reported alterations in mechanical withdrawal thresholds in a simulated jet lag paradigm ( Das et al, 2018 ). A final study examined the effect of mistimed eating on mechanical withdrawal thresholds in a mouse model of neuropathic pain ( Xu et al, 2018 ). Food consumption restricted to the inactive phase exaggerated mechanical allodynia in male mice with chronic constriction injury ( Xu et al, 2018 ).…”

Section: Circadian Rhythm Disruption Pain and Opioids: A Feedback Loopmentioning

confidence: 99%

The disruptive relationship among circadian rhythms, pain, and opioids

2023

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Pain behavior and the systems that mediate opioid analgesia and opioid reward processing display circadian rhythms. Moreover, the pain system and opioid processing systems, including the mesolimbic reward circuitry, reciprocally interact with the circadian system. Recent work has demonstrated the disruptive relationship among these three systems. Disruption of circadian rhythms can exacerbate pain behavior and modulate opioid processing, and pain and opioids can influence circadian rhythms. This review highlights evidence demonstrating the relationship among the circadian, pain, and opioid systems. Evidence of how disruption of one of these systems can lead to reciprocal disruptions of the other is then reviewed. Finally, we discuss the interconnected nature of these systems to emphasize the importance of their interactions in therapeutic contexts.

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“…96,97 Misaligned diet and sleep deprivation during the peri-CCI surgery and post-CCI distinctly decrease the paw withdrawal mechanical threshold, whereas melatonin pretreatment ameliorates the hypersensitivity and reverses the disturbed sleep rhythm. 94,98 In other neuropathic pain models, such as cuff implantation, valproic acid, and paclitaxel, melatonin ameliorates mechanical and thermal allodynia by preventing the increases in NO levels, down-regulating c-fos, and increasing C-fiber activity. 17,99,100 Growing evidence suggests that melatonin administration may reverse the nociceptive threshold in spinal nerve ligation (SNL) rodents.…”

Section: Neuropathic Painmentioning

confidence: 99%

“…61 The up-regulation of NMDA receptor subtype 2B (NR2B), Ca 2+ /calmodulin-dependent protein kinase II (CaMKII), and cyclic adenosine monophosphate-response element-binding protein (CREB) is induced by nerve injury, which can be recovered by melatonin pretreatment. 98 Furthermore, melatonin administration attenuates the NR1 expression and reduces NMDA-induced currents in dorsal horn neurons in rodents with unilateral temporomandibular joint (TMJ) inflammation in a dose-dependent manner. 134 The treatment of neuropathic pain achieves more efficacy using a combination of melatonin and dextromethorphan (DM; a clinically available NMDA receptor antagonist).…”

Section: Nmda Receptorsmentioning

confidence: 99%

<p>Role of Melatonin in the Regulation of Pain</p>

Xie

Fan

et al. 2020

JPR

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Melatonin is a pleiotropic hormone synthesized and secreted mainly by the pineal gland in vertebrates. Melatonin is an endogenous regulator of circadian and seasonal rhythms. Melatonin is involved in many physiological and pathophysiological processes demonstrating antioxidant, antineoplastic, anti-inflammatory, and immunomodulatory properties. Accumulating evidence has revealed that melatonin plays an important role in pain modulation through multiple mechanisms. In this review, we examine recent evidence for melatonin on pain regulation in various animal models and patients with pain syndromes, and the potential cellular mechanisms.

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Misaligned Feeding May Aggravate Pain by Disruption of Sleep–Awake Rhythm

Abstract: Misaligned diet might aggravate pain sensitivity through the disruption of the sleep-awake cycle, which could be recovered by Mel. NR2B-CaMKII-CREB may participate in the disruption of sleep-awake rhythm-mediated pain aggravation.

Cited by 10 publications

References 26 publications

Changes in the rest-activity rhythm in migraine patients are associated with anxiety symptoms

Changes in the rest-activity rhythm in migraine patients are associated with anxiety symptoms

The disruptive relationship among circadian rhythms, pain, and opioids

<p>Role of Melatonin in the Regulation of Pain</p>

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