&lt;p&gt;Role of Melatonin in the Regulation of Pain&lt;/p&gt;

Xie, Shanshan; Fan, Wenguo; He, Hongwen; Huang, Fang

doi:10.2147/jpr.s228577

Cited by 44 publications

(37 citation statements)

References 147 publications

(167 reference statements)

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“…In the present study, patients receiving melatonin needed a lower dose of analgesia, and this decrease in analgesic dose increased with increasing melatonin dose. The finding of our study seems more logical considering that the analgesic effect of melatonin is dose-dependent and increases with increasing dose [ [35] , [36] , [37] ].…”

Section: Discussionmentioning

confidence: 94%

Effects of preoperative melatonin on postoperative pain following cesarean section: A randomized clinical trial

Kiabi

Emadi

Jamkhaneh

et al. 2021

Annals of Medicine &Amp; Surgery

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Background Data regarding the analgesic effects of melatonin after the surgery is scare. So far, only one study has investigated the analgesic effect of melatonin during cesarean section. Objective : The present study was performed to investigate the effect of preoperative oral melatonin on pain intensity after cesarean section during spinal anesthesia. Methods In a double-blind randomized controlled clinical trial study, 204 patients undergoing elective cesarean section with class 1 and 2 anesthesia (ASA) were enrolled. Patients were randomly divided into 3 groups of 68 patients. Patients in group A were given 5 mg melatonin tablets, patients in group B were given 10 mg melatonin tablets, and group C was given placebo. All patients underwent spinal anesthesia with the same anesthesia protocol. Pain intensity, nausea, vomiting, pruritus and headache were assessed and recorded 2, 6, 12 and 24 h after surgery. The time of first dose of analgesia, the amount of opioid consumed within 24 h, and the time to resume physical activity was also recorded. Statistical analysis of data was performed using SPSS 20 software. Results Repeated measurements of pain intensity during the study showed that in all 3 groups pain intensity was significantly reduced during the study, p < 0.001, respectively. The intensity of pain was significantly different in groups B and C, groups B and A and groups A and C, P < 0.001, respectively. The pain reduction was greatest in group B, followed by group A and group C, respectively. The time interval between the end of surgery and the patient's need for analgesia was significant in group B compared to group A (P = 0.035) and C (P < 0.001) and also in group A compared to group C (P = 0.011). The mean dose of opioid was significantly least in group B, p < 0.001. The mean time to resume physical activity was also shortest in group B, p < 0.001 Headache and nausea/vomiting were observed in 7 patients (10.7%) group A and 7 patients (10.7%) in group C. None of the patients in group B developed complications. Conclusion The results of the present study showed that the use of 10 mg of melatonin before cesarean section with spinal anesthesia is not only safe, but also reduces the severity of patients' pain, increases the duration of postoperative analgesia, reduces the need for analgesics after surgery and resumption of physical activity.

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Section: Discussionmentioning

confidence: 94%

Effects of preoperative melatonin on postoperative pain following cesarean section: A randomized clinical trial

Kiabi

Emadi

Jamkhaneh

et al. 2021

Annals of Medicine &Amp; Surgery

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“…During day, the exposure to light induces the breakdown of melanopsin in retinal photoreceptive ganglion cells, which signals through retinohypothalamic pathway to inhibit the synthesis of melatonin, consequently, the levels of melatonin are low during daylight and rise in dark at night [3]. The neurotransmitters such as noradrenaline and GABA regulate the synthesis of Melatonin [29]. The presence of 5-methoxy and N-acetyl functional groups in the structure of melatonin impart specificity and amphiphilicity, and melatonin can readily cross the plasma membranes affecting almost all the cells of the body [3].…”

Section: Synthesis and Metabolism Of Melatoninmentioning

confidence: 99%

“…The pain-relieving effects of melatonin either stem from its direct anti-nociceptive effects due to its anti-oxidant, anti-inflammatory properties and direct interaction with its cognate receptors or through indirect complex interactions with other systems that can modulate the pain perception pathways [29,37].…”

Section: Mechanisms Of Melatonin Action In Relieving Painmentioning

confidence: 99%

Melatonin Moderates the Triangle of Chronic Pain, Sleep Architecture and Immunometabolic Traffic

et al. 2021

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Preclinical as well as human studies indicate that melatonin is essential for a physiological sleep state, promotes analgesia and is involved in immunometabolic signaling by regulating neuroinflammatory pathways. Experimental and clinical neuromodulation studies for chronic pain treatment suggest that neurostimulation therapies such as spinal cord stimulation, vagus nerve stimulation and dorsal root ganglion stimulation have an impact on circulating inflammatory mediators in blood, cerebrospinal fluid and saliva. Herein, we provide an overview of current literature relevant for the shared pathways of sleep, pain and immunometabolism and elaborate the impact of melatonin on the crossroad of sleep, chronic pain and immunometabolism. Furthermore, we discuss the potential of melatonin as an adjunct to neurostimulation therapies. In this narrative review, we addressed these questions using the following search terms: melatonin, sleep, immunometabolism, obesity, chronic pain, neuromodulation, neurostimulation, neuroinflammation, molecular inflammatory phenotyping. So far, the majority of the published literature is derived from experimental studies and studies specifically assessing these relationships in context to neurostimulation are sparse. Thus, the adjunct potential of melatonin in clinical neurostimulation has not been evaluated under the umbrella of randomized-controlled trials and deserves increased attention as melatonin interacts and shares pathways relevant for noninvasive and invasive neurostimulation therapies.

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“…Melatonin is a neurohormone produced by the pineal gland. This molecule has many beneficial activities, including immunomodulatory, anti-inflammatory, antioxidant properties within the body [ 158 , 159 ]. Because of these functions, some researchers have proposed this agent could be a therapeutic option for treating viral infections and respiratory diseases, including ARDS and acute lung injury (ALI) [ 160 ].…”

Section: Passive Immunotherapy For Sars-cov-2mentioning

confidence: 99%

Novel insights into the treatment of SARS-CoV-2 infection: An overview of current clinical trials

Oroojalian

Haghbin

Baradaran

et al. 2020

International Journal of Biological Macromolecules

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The emergence of the global pandemic caused by the novel SARS-CoV-2 virus has motivated scientists to find a definitive treatment or a vaccine against it in the shortest possible time. Current efforts towards this goal remain fruitless without a full understanding of the behavior of the virus and its adaptor proteins. This review provides an overview of the biological properties, functional mechanisms, and molecular components of SARS-CoV-2, along with investigational therapeutic and preventive approaches for this virus. Since the proteolytic cleavage of the S protein is critical for virus penetration into cells, a set of drugs, such as chloroquine, hydroxychloroquine, camostat mesylate have been tested in clinical trials to suppress this event. In addition to angiotensin-converting enzyme 2, the role of CD147 in the viral entrance has also been proposed. Mepolizumab has shown to be effective in blocking the virus's cellular entrance. Antiviral drugs, such as remdesivir, ritonavir, oseltamivir, darunavir, lopinavir, zanamivir, peramivir, and oseltamivir, have also been tested as treatments for COVID-19. Regarding preventive vaccines, the whole virus, vectors, nucleic acids, and structural subunits have been suggested for vaccine development. Mesenchymal stem cells and natural killer cells could also be used against SARS-CoV-2. All the above-mentioned strategies, as well as the role of nanomedicine for the diagnosis and treatment of SARS-CoV-2 infection, have been discussed in this review.

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<p>Role of Melatonin in the Regulation of Pain</p>

Cited by 44 publications

References 147 publications

Effects of preoperative melatonin on postoperative pain following cesarean section: A randomized clinical trial

Effects of preoperative melatonin on postoperative pain following cesarean section: A randomized clinical trial

Melatonin Moderates the Triangle of Chronic Pain, Sleep Architecture and Immunometabolic Traffic

Novel insights into the treatment of SARS-CoV-2 infection: An overview of current clinical trials

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