Mirtazapine versus amitriptyline in the long-term treatment of depression

Montgomery, Stuart; Reimitz, Paul-Egbert; Zivkov, M.

doi:10.1097/00004850-199803000-00002

Cited by 108 publications

(53 citation statements)

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“…In the treatment of depression, mirtazapine is significantly more effective than placebo, has equivalent efficacy versus amitriptyline [3][4][5], clomipramine [6], and doxepin [7] and is significantly more effective than trazodone [8]. More recent studies have shown that mirtazapine is at least as effective as the SSRIs fluoxetine [9], citalopram [10] and paroxetine [11], but they also suggest that mirtazapine has a faster onset of action than these SSRIs [9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Effects of Mirtazapine on Sleep Polygraphic Variables in Major Depression

Schittecatte¹,

Dumont²,

Machowski³

et al. 2002

Neuropsychobiology

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Mirtazapine, a noradrenergic and specific serotonergic antidepressant(NaSSA), was administered on a flexible schedule in a sample of 17 drug-free patients meeting DSM-IV criteria for a major depressive episode. Sleep polygraphic recordings were performed before and during acute and chronic treatment. Severity of depression and subjective assessment of changes within different aspects of sleep were also evaluated. During the acute administration (first 2 days), mirtazapine significantly increased total sleep time, sleep efficiency, stage II, stage rapid eye movement and slow-wave sleep percentages, and decreased sleep latency and stage awake percentage. These effects persisted after 5 weeks of treatment. Subjectively, mirtazapine induced an improvement of sleep. This open, noncontrolled study suggests that mirtazapine ameliorates the sleep disturbances encountered in depressed patients both objectively and subjectively.

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Section: Introductionmentioning

confidence: 99%

Effects of Mirtazapine on Sleep Polygraphic Variables in Major Depression

Schittecatte¹,

Dumont²,

Machowski³

et al. 2002

Neuropsychobiology

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show abstract

“…Um estudo de 2 anos de duração, com 217 pacientes depressivos 26 , comparou o uso da mirtazapina (ANG), dosagem máxima de 35mg/ dia, com a amitriptilina, máximo de 280mg/dia e um grupo controle (que recebia placebo). A proporção de pacientes que apresentaram aumento importante (>7%) no peso corporal de acordo com a droga utilizada foi: amitriptilina=22% dos pacientes; mirtazapina=12,7% e placebo=3,6%.…”

Section: Antidepressivos De Classes Diferentesunclassified

“…Portanto, os estudos que comparam mudanças no peso entre as diferentes classes de antidepressivos, demonstram o efeito dos ADT no ganho de peso nas primeiras semanas 24,25 , sendo que em tratamento por mais de um ano, não houve diferença no ganho de peso corporal entre os tipos de antidepressivos 26 . Entre os ANG, a mirtazapina parece se associar a um maior ganho de peso a longo prazo, enquanto que a venlafaxina e a bupropiona parecem ser neutros no ganho de peso 35 .…”

Section: Antidepressivos De Classes Diferentesunclassified

Antidepressivos e alterações no peso corporal

et al. 2008

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A depressão é uma doença que pode levar a mudanças no peso, influenciadas por fatores específicos da doença, como alterações no apetite e na atividade física, ou pelos antidepressivos. Este artigo objetiva analisar os estudos que descrevem os efeitos dos antidepressivos em alterações do peso corporal. Realizou-se uma pesquisa nas bases de dados Medline, Lilacs e Cochrane, utilizando as palavras chaves "antidepressivo" e "peso". Foram selecionados os estudos que analisaram o tema em pacientes depressivos, priorizando-se aqueles relacionados às drogas mais utilizadas nos serviços de saúde no Brasil. A análise dos estudos indicou que a mudança de peso atribuída ao tratamento com antidepressivos apresenta resultados ainda controversos, sendo influenciada por fatores como o tempo de uso e a dosagem do medicamento, estudos com poder limitado, entre outros. Assim, estudos com maior poder, tendo como foco a ação das drogas antidepressivas nas alterações do peso corporal em pacientes depressivos, ainda são necessários. Termos de indexação:Antidepressivos. Ganho/Perda de peso. Peso corporal. A B S T R A C T Depression is a disorder that may affect patient's weight because of specific factors of the disease, such as changes in appetite and

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“…The therapeutic effi cacy of orally applied mirtazapine has been proven in double-blind, placebo-controlled studies [10][11][12] as well as controlled trials comparing mirtazapine with tricyclic antidepressants [13][14][15] . Preliminary fi ndings indicate that the intravenous application of mirtazapine is safe and well tolerated [16] , relying, however, on a relatively small sample size.…”

Section: Introductionmentioning

confidence: 99%

Intravenous Mirtazapine Is Safe and Effective in the Treatment of Depressed Inpatients

et al. 2006

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Mirtazapine is a third-generation antidepressant with a dual mode of action. The oral administration has been shown to be effective and safe in the treatment of depressed patients. In this multicenter naturalistic study, we assessed the safety, tolerability, and therapeutic efficacy of intravenously administered mirtazapine in 80 moderately to severely depressed inpatients during a treatment period of 14 days. We found a significant decrease of the Hamilton Depression Rating Scale total score compared to baseline. Side effects were mild and transient. Our data indicate that intravenous mirtazapine is an effective, safe and well-tolerated treatment for depressed inpatients.

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Mirtazapine versus amitriptyline in the long-term treatment of depression

Cited by 108 publications

References 0 publications

Effects of Mirtazapine on Sleep Polygraphic Variables in Major Depression

Effects of Mirtazapine on Sleep Polygraphic Variables in Major Depression

Antidepressivos e alterações no peso corporal

Intravenous Mirtazapine Is Safe and Effective in the Treatment of Depressed Inpatients

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