Mirror therapy in upper limb motor recovery and activities of daily living, and its neural correlates in stroke individuals: A systematic review and meta-analysis

Nogueira, Nathálya Gardênia de Holanda Marinho; Parma, Juliana Otoni; Leão, Sara Edith Souza de Assis; Sales, Izabella de Souza; Macedo, Lilian Carla; Galvão, Ana Carolina Daher Ribas; Oliveira, Dalva Cadeu de; Murça, Tatiane M.; Fernandes, Lidiane Aparecida; Junqueira, Cristiani; Lage, Guilherme Menezes; Ferreira, Bárbara de Paula

doi:10.1016/j.brainresbull.2021.10.003

Cited by 24 publications

(23 citation statements)

References 74 publications

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“…Neurorehabilitation therapies based on mirror neuron and embodied cognition theory play a vital role in motor dysfunction after stroke and are widely used in clinical rehabilitation nowadays ( 11 , 47 , 48 ). However, insufficient attention has been paid to sensory function rehabilitation.…”

Section: Discussionmentioning

confidence: 99%

Comparison of Sensory Observation and Somatosensory Stimulation in Mirror Neurons and the Sensorimotor Network: A Task-Based fMRI Study

Zhou

Chen

Li³

et al. 2022

Front. Neurol.

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ObjectiveThis study aimed to investigate brain plasticity by somatosensory stimulation (SS) and sensory observation (SO) based on mirror neuron and embodied cognition theory. Action observation therapy has been widely adopted for motor function improvement in post-stroke patients. However, it is uncertain whether the SO approach can also contribute to the recovery of sensorimotor function after stroke. In this study, we explored the therapeutic potential of SO for sensorimotor dysfunction and provided new evidence for neurorehabilitation.MethodsTwenty-six healthy right-handed adults (12 men and 14 women), aged 18–27 (mean, 22.12; SD, 2.12) years were included. All subjects were evaluated with task-based functional magnetic resonance imaging (fMRI) to discover the characteristics and differences in brain activation between SO and SS. We adopted a block design with two conditions during fMRI scanning: observing a sensory video of brushing (task condition A, defined as SO) and brushing subjects' right forearms while they watched a nonsense string (task condition B, defined as SS). One-sample t-tests were performed to identify brain regions and voxels activated for each task condition. A paired-sample t-test and conjunction analysis were performed to explore the differences and similarities between SO and SS.ResultsThe task-based fMRI showed that the bilateral postcentral gyrus, left precentral gyrus, bilateral middle temporal gyrus, right supramarginal gyrus, and left supplementary motor area were significantly activated during SO or SS. In addition to these brain regions, SO could also activate areas containing mirror neurons, like the left inferior parietal gyrus.ConclusionSO could activate mirror neurons and sensorimotor network-related brain regions in healthy subjects like SS. Therefore, SO may be a promising novel therapeutic approach for sensorimotor dysfunction recovery in post-stroke patients.

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Section: Discussionmentioning

confidence: 99%

Comparison of Sensory Observation and Somatosensory Stimulation in Mirror Neurons and the Sensorimotor Network: A Task-Based fMRI Study

Zhou

Chen

Li³

et al. 2022

Front. Neurol.

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“…Mirror therapy was first proposed in 1996 and effectively reduced pain in patients with amputated arms ( Ramachandran and Rogers-Ramachandran, 1996 ). Subsequently, studies conducted in stroke patients with hemiplegia after ictus showed that mirror therapy could significantly rehabilitate patients with upper limb motor dysfunction ( Yavuzer et al, 2008 ; Nogueira et al, 2021 ; Zhuang et al, 2021 ). In addition, the role and impact of mirror therapy have also been explored in lower limb motor rehabilitation ( Sütbeyaz et al, 2007 ; Li et al, 2018 ; Louie et al, 2019 ).…”

Section: Mirror Therapymentioning

confidence: 99%

Emerging Limb Rehabilitation Therapy After Post-stroke Motor Recovery

Xiong

Liao

Xiao

et al. 2022

Front. Aging Neurosci.

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Stroke, including hemorrhagic and ischemic stroke, refers to the blood supply disorder in the local brain tissue for various reasons (aneurysm, occlusion, etc.). It leads to regional brain circulation imbalance, neurological complications, limb motor dysfunction, aphasia, and depression. As the second-leading cause of death worldwide, stroke poses a significant threat to human life characterized by high mortality, disability, and recurrence. Therefore, the clinician has to care about the symptoms of stroke patients in the acute stage and formulate an effective postoperative rehabilitation plan to facilitate the recovery in patients. We summarize a novel application and update of the rehabilitation therapy in limb motor rehabilitation of stroke patients to provide a potential future stroke rehabilitation strategy.

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“…Efforts have been made to develop therapies that can improve motor impairment in stroke patients (9). Among these therapies are: constraint-induced movement (10), mirror therapy (11), and resistance training (12), however, these interventions have a low level of adherence (13) and the evidence supporting their effects is still weak (10)(11)(12). Recently, Vagus Nerve Stimulation (VNS) has been proposed as an intervention that could have beneficial effects in the recovery of motor function in these patients, since it contributes to the generation of adaptive neuroplasticity and the activation of neuromodulators that reduce brain inflammation (14,15).…”

Section: Introductionmentioning

confidence: 99%

Efficacy and Safety of Vagus Nerve Stimulation on Upper Limb Motor Recovery After Stroke. A Systematic Review and Meta-Analysis

et al. 2022

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BackgroundUpper limb motor impairment is one of the main complications of stroke, affecting quality of life both for the patient and their family. The aim of this systematic review was to summarize the scientific evidence on the safety and efficacy of Vagus Nerve Stimulation (VNS) on upper limb motor recovery after stroke.MethodsA systematic review and meta-analysis of studies that have evaluated the efficacy or safety of VNS in stroke patients was performed. The primary outcome was upper limb motor recovery. A search of articles published on MEDLINE, CENTRAL, EBSCO and LILACS up to December 2021 was performed, and a meta-analysis was developed to calculate the overall effects.ResultsEight studies evaluating VNS effects on motor function in stroke patients were included, of which 4 used implanted and 4 transcutaneous VNS. It was demonstrated that VNS, together with physical rehabilitation, increased upper limb motor function on average 7.06 points (95%CI 4.96; 9.16) as assessed by the Fugl-Meyer scale. Likewise, this improvement was significantly greater when compared to a control intervention (mean difference 2.48, 95%CI 0.98; 3.98). No deaths or serious adverse events related to the intervention were reported. The most frequent adverse events were dysphonia, dysphagia, nausea, skin redness, dysgeusia and pain related to device implantation.ConclusionVNS, together with physical rehabilitation, improves upper limb motor function in stroke patients. Additionally, VNS is a safe intervention.

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Mirror therapy in upper limb motor recovery and activities of daily living, and its neural correlates in stroke individuals: A systematic review and meta-analysis

Cited by 24 publications

References 74 publications

Comparison of Sensory Observation and Somatosensory Stimulation in Mirror Neurons and the Sensorimotor Network: A Task-Based fMRI Study

Comparison of Sensory Observation and Somatosensory Stimulation in Mirror Neurons and the Sensorimotor Network: A Task-Based fMRI Study

Emerging Limb Rehabilitation Therapy After Post-stroke Motor Recovery

Efficacy and Safety of Vagus Nerve Stimulation on Upper Limb Motor Recovery After Stroke. A Systematic Review and Meta-Analysis

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