MiRNA-144–5p down-modulates CDCA3 to regulate proliferation and apoptosis of lung adenocarcinoma cells

Luo, Jing; Xia, Lilong; Zhang, Lei; Zhao, Kaixiang; Li, Chuanchuan

doi:10.1016/j.mrfmmm.2022.111798

Cited by 9 publications

(4 citation statements)

References 33 publications

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“…TGFB1 belongs to the TGF-β family and serves as one of the most active multifunctional cellular activity regulators [ 25 ]. While TGFB1 acts as a potent growth suppressor in multicellular organisms and significantly inhibits lymphocytes, it also promotes fibroblast cell proliferation, the expression of extracellular matrix proteins, and the synthesis of bone matrix proteins [ 26 ]. Therefore, it suggests that the physiological activity of cell proliferation is attenuated in women compared to men in the disease state.…”

Section: Resultsmentioning

confidence: 99%

Identification and Analysis of Sex-Biased MicroRNAs in Human Diseases

Zhong,

Cui,

Cui

2023

Genes

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It is well known that significant differences exist between males and females in both physiology and disease. Thus, it is important to identify and analyze sex-biased miRNAs. However, previous studies investigating sex differences in miRNA expression have predominantly focused on healthy individuals or restricted their analysis to a single disease. Therefore, it is necessary to comprehensively identify and analyze the sex-biased miRNAs in diseases. For this purpose, in this study, we first identified the miRNAs showing sex-biased expression between males and females in diseases based on a number of miRNA expression datasets. Then, we performed a bioinformatics analysis for these sex-biased miRNAs. Notably, our findings revealed that women exhibit a greater number of conserved miRNAs that are highly expressed compared to men, and these miRNAs are implicated in a broader spectrum of diseases. Additionally, we explored the enriched transcription factors, functions, and diseases associated with these sex-biased miRNAs using the miRNA set enrichment analysis tool TAM 2.0. The insights gained from this study could carry implications for endeavors such as precision medicine and possibly pave the way for more targeted and tailored approaches to disease management.

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Section: Resultsmentioning

confidence: 99%

Identification and Analysis of Sex-Biased MicroRNAs in Human Diseases

Zhong,

Cui,

Cui

2023

Genes

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“…41,42 The pairing between miRNA and target mRNA may not be specific, thereby allowing miRNAs to regulate a wide range of mRNA targets. 43 miRNA is involved in all cell activity regulation, including cell proliferation, 44,45 differentiation, 46 apoptosis, 47 and pyroptosis. 48 lncRNAs are also transcribed by RNA polymerase II and play a key role in gene activation and silencing, alternative splicing, and posttranslational modification in organisms.…”

Section: Ncrnasmentioning

confidence: 99%

“…The pairing between miRNA and target mRNA may not be specific, thereby allowing miRNAs to regulate a wide range of mRNA targets 43 . miRNA is involved in all cell activity regulation, including cell proliferation, 44,45 differentiation, 46 apoptosis, 47 and pyroptosis 48 …”

Section: The Role Of Ncrnas In Diabetes and Vcdmentioning

confidence: 99%

The role of ncRNAs‐mediated pyroptosis in diabetes and its vascular complications

Feng,

Yang,

Zhong

et al. 2024

Cell Biochemistry & Function

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Over the past decade, the prevalence of diabetes has increased significantly worldwide, leading to an increase in vascular complications of diabetes (VCD), such as diabetic cardiomyopathy (DCM), diabetic nephropathy (DN), and diabetic retinopathy (DR). Noncoding RNAs (ncRNAs), such as microRNAs (miRNAs), long Noncoding RNAs (lncRNAs), and circular RNAs (circRNAs), play a key role in cellular processes, including the pathophysiology of diabetes and VCD via pyroptosis. ncRNAs (e.g., miR‐17, lnc‐MEG3, and lnc‐KCNQ1OT1) can regulate pyroptosis in pancreatic β cells. Some ncRNAs are involved in VCD progression. For example, miR‐21, lnc‐KCNQ1OT1, lnc‐GAS5, and lnc‐MALAT1 were reported in DN and DCM, and lnc‐MIAT was identified in DCM and DR. Herein, this review aimed to summarize recent research findings related to ncRNAs‐mediated pyroptosis at the onset and progression of diabetes and VCD.

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“…Uncontrolled proliferation and escape from apoptosis are the most defining characteristics of tumor cells. However, the regulatory network involved in proliferation and apoptosis remains unclear and need to be further clarified (116). NcRNAs has been demonstrated to be vital regulators of the two cellular processes in LC.…”

Section: Ncrna In Lc Proliferation and Apoptosismentioning

confidence: 99%

Non-coding RNAs in lung cancer: molecular mechanisms and clinical applications

Liu,

Ding,

Wang

et al. 2023

Front. Oncol.

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Lung cancer (LC) is a heterogeneous disease with high malignant degree, rapid growth, and early metastasis. The clinical outcomes of LC patients are generally poor due to the insufficient elucidation of pathological mechanisms, low efficiency of detection and assessment methods, and lack of individualized therapeutic strategies. Non-coding RNAs (ncRNAs), including microRNA (miRNA), long non-coding RNA (lncRNA), and circular RNA (circRNA), are endogenous regulators that are widely involved in the modulation of almost all aspects of life activities, from organogenesis and aging to immunity and cancer. They commonly play vital roles in various biological processes by regulating gene expression via their interactions with DNA, RNA, or protein. An increasing amount of studies have demonstrated that ncRNAs are closely correlated with the initiation and development of LC. Their dysregulation promotes the progression of LC via distinct mechanisms, such as influencing protein activity, activating oncogenic signaling pathways, or altering specific gene expression. Furthermore, some ncRNAs present certain clinical values as biomarker candidates and therapeutic targets for LC patients. A complete understanding of their mechanisms in LC progression may be highly beneficial to developing ncRNA-based therapeutics for LC patients. This review mainly focuses on the intricate mechanisms of miRNA, lncRNA, and circRNA involved in LC progression and discuss their underlying applications in LC treatment.

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MiRNA-144–5p down-modulates CDCA3 to regulate proliferation and apoptosis of lung adenocarcinoma cells

Cited by 9 publications

References 33 publications

Identification and Analysis of Sex-Biased MicroRNAs in Human Diseases

Identification and Analysis of Sex-Biased MicroRNAs in Human Diseases

The role of ncRNAs‐mediated pyroptosis in diabetes and its vascular complications

Non-coding RNAs in lung cancer: molecular mechanisms and clinical applications

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