MiR-451 as a new tumor marker for gastric cancer

Abstract

Gastric cancer is the second most common malignancy in China. However, the prognosis for gastric cancer patients remains poor. The purpose of this study was to investigate whether miR-451 was a potential prognostic biomarker for gastric cancer. Fresh tissues were immediately frozen in liquid nitrogen until use. The plasma was extracted and quantitative real-time polymerase chain reaction was performed to detect miR-451 expression. The Student's t test analysis and multivariate Cox regression analysis were performed to analyze expression of miR-451. The analysis results showed that the expression level of miR-451 was decreased expression in gastric cancer tissue. The down-regulation of miR-451 tended to be positively correlated with tumor stage, lymphatic metastasis and shorter overall survival of patients. MiR-451 may be a potential biomarker and a potential therapeutic target for the diagnoses and prognosis of gastric cancer.

Increased T‐helper 17 cell differentiation mediated by exosome‐mediated microRNA‐451 redistribution in gastric cancer infiltrated T cells

“…miRNA expression profiling analyses have recently identified miR‐451 as a highly conserved miRNA expressed in several species, including mice and humans . Many studies have established that miR‐451 is widely dysregulated in human malignancies, including lung cancer, gastric cancer, breast cancer, glioma, and leukemia . Some studies have indicated miR‐451 as an anti‐cancer gene that can inhibit cell growth, proliferation, invasion and enhance apoptosis .…”

MicroRNA-100 suppresses human gastric cancer cell proliferation by targeting CXCR7

“…Mounting evidences have demonstrated that aberrant expression of several miRNAs is associated with survival outcome of cancer patients (27,28) and therefore could be regarded as potential therapeutic targets for these cancers. Take GC as an example, numerous miRNAs have been identified involved in GC development, but their underlying molecular mechanism in GC development is still poorly understood (7,14). Therefore, in this present study, we aimed to identify new miRNA biomarker that could be used as predictor for the overall survival of GC patients and also with the hope to reveal the underlying mechanism of how miRNA participated in the development of GC.…”

“…Dysregulation of miRNAs in diseases especially in tumor has attracted extensive attentions in recent years (7)(8)(9)(10)(11)(12). Mounting evidences have demonstrated that aberrant expression of several miRNAs is associated with survival outcome of cancer patients (27,28) and therefore could be regarded as potential therapeutic targets for these cancers.…”

“…Accumulating evidences have revealed that altered expression of miRNAs play an important role in tumorigenesis of many human cancers (7)(8)(9). In the mean time, studies have demonstrated that a single cancer can be driven by different miRNAs (7,10,11), while a single miRNA can be found aberrant expressed in different cancers (11,12).…”

“…Accumulating evidences have revealed that altered expression of miRNAs play an important role in tumorigenesis of many human cancers (7)(8)(9). In the mean time, studies have demonstrated that a single cancer can be driven by different miRNAs (7,10,11), while a single miRNA can be found aberrant expressed in different cancers (11,12). As for GC, a number of miRNAs have reported to participate in a variety of physiological processes such as cell proliferation, differentiation, and apoptosis via regulating several target genes (13)(14)(15).…”