miR-296-5p suppresses stem cell potency of hepatocellular carcinoma cells via regulating Brg1/Sall4 axis

Shi, Dongmin; Shi, Xiaoli; Xing, Kailin; Zhou, Hongxin; Lü, Lili; Wu, Wei‐Zhong

doi:10.1016/j.cellsig.2020.109650

Cited by 30 publications

(16 citation statements)

References 44 publications

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“…For instance, miR-296-5p attenuates the epithelial–mesenchymal transition (EMT) program through Neuregulin (1NRG1)/erb-b2 receptor tyrosine kinase 2 (ERBB2)/ERBB3 signaling. Moreover, miR-296-5p exerts an inhibitory effect on the stemness potency of HCC cells via direct targeting of the Brahma-related gene-1 (BRG1)/Sal-like protein 4 (SALL4) axis [ 114 ]. MiR-486-3p is downregulated in sorafenib-resistant HCC cell lines and tumor tissue relative to adjacent normal tissue in HCC patients and could induce apoptosis by targeting fibroblast growth factor receptor 4 (FGFR4) and EGFR [ 115 ].…”

Section: Discussionmentioning

confidence: 99%

Functional roles of non-coding RNAs regulated by thyroid hormones in liver cancer

et al. 2021

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Recent reports have shown the important role of the non-coding part of human genome RNA (ncRNA) in cancer formation and progression. Among several kinds of ncRNAs, microRNAs (miRNA) play a pivotal role in cancer biology. Accumulating researches have been focused on the importance of non-coding genes in various diseases. In addition to miRNAs, long non-coding RNAs (lncRNAs) have also been extensively documented. Recently, the study of human liver cancer has gradually shifted to these non-coding RNAs that were originally considered “junk”. Notably, dysregulated ncRNAs maybe influence on cell proliferation, angiogenesis, anti-apoptosis, and metastasis. Thyroid hormones play critical roles in human development and abnormalities in thyroid hormone levels are associated with various diseases, such as liver cancer. Thyroid hormone receptors (TR) act as ligand-activated nuclear transcription factors to affect multiple functions through the gene-level regulation in the cells and several studies have revealed that thyroid hormone associated with ncRNAs expression. TR actions are complex and tissue- and time-specific, aberrant expression of the various TR isoforms have different effects and are associated with different types of tumor or stages of development. In this review, we discuss various aspects of the research on the thyroid hormones modulated ncRNAs to affect the functions of human liver cells.

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Section: Discussionmentioning

confidence: 99%

Functional roles of non-coding RNAs regulated by thyroid hormones in liver cancer

et al. 2021

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“…In lung adenocarcinoma, miR-296-3p also contributes to the inhibition of Ras, leading to the increased chemotherapy sensitivity [78]. It is also reported that miR-296-5p inhibited stemness potency and EMT via BRM/SWI2-related gene 1 and neuregulin 1, respectively [79]. Intriguingly, miR-95 knockdown could repress EMT and CSCs phenotype through dual frizzled class receptor 4, GATA3 GATA binding protein 3, GBM Glioblastoma, GC gastric cancer, HCPT hydroxycamptothecine, IGF1R insulin like growth factor 1 receptor, LC lung cancer, MK2 MAPK activated protein kinase 2, MRP5 multidrug resistant protein 5, NA not acquired, NIN1 Netrin 1, NPC Nasopharyngeal carcinoma, OC ovarian cancer, Oct4 Octamer-binding protein 4, ONECUT2 one cut homeobox 2, PC Pancreatic cancer, PRKCA Protein kinase C alpha, RAC1 Ras-related C3 botulinum toxin substrate 1, Rab6 Ras-related protein Rab-6a, RKIP Raf kinase inhibitory protein, SN38 7-ethyl-10-hydroxycamptothecin, SOX SRY-box transcription factor, TGM2 transglutaminase 2, TMZ temozolomide, TP53INP1 tumor protein P53 inducible nuclear protein 1, YAP1 Yes associated protein 1 specificity phosphatase 5-dependent MAPK pathway [80].…”

Section: Mirnas Inhibit Emt To Overcome Chemotherapy Resistancementioning

confidence: 96%

MiRNA-mediated EMT and CSCs in cancer chemoresistance

Dong

Zhu

et al. 2021

Exp Hematol Oncol

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Cancer stem cells (CSCs) are a small group of cancer cells, which contribute to tumorigenesis and cancer progression. Cancer cells undergoing epithelial-to-mesenchymal transition (EMT) acquire the chemoresistant ability, which is regarded as an important feature of CSCs. Thus, there emerges an opinion that the generation of CSCs is considered to be driven by EMT. In this complex process, microRNAs (miRNAs) are found to play a key role. In order to overcome the drug resistance, inhibiting EMT as well as CSCs phenotype seem feasible. Thereinto, regulating the EMT- or CSCs-associated miRNAs is a crucial approach. Herein, we conduct this review to elaborate on the complicated interplay between EMT and CSCs in cancer chemoresistance, which is modulated by miRNAs. In addition, we elucidate the therapeutic strategy to overcome drug resistance through targeting EMT and CSCs.

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“…Patients with high ERBB2 expression are prone to tumor metastasis and have a short survival period, which has become an ideal target of tumor immunobiotherapy and a hot molecule in the field of tumor therapy. It has been found that mir-296-5p inhibits EMT related metastasis of liver cancer through ERBB2 signaling pathway [ 34 , 35 ]. Mir-375 upregulates cell proliferation and apoptosis by targeting ERBB2 and inhibits the growth of human hepatoma cells [ 36 ].…”

Section: Discussionmentioning

confidence: 99%

Uncovering the Mechanism of the Effects of Pien-Tze-Huang on Liver Cancer Using Network Pharmacology and Molecular Docking

Liu

Wang

Lou

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Pien-Tze-Huang (PTH) has a long history in the treatment of liver cancer. However, its molecular mechanism of action remains unclear. TCMSP and TCM were used to collect the active ingredients. Bioactive compounds targets were predicted by reverse pharmacophore models. The antiliver cancer targets of PTH were selected by gene comparison of liver cancer in the GEO database. Molecular docking was used to verify the binding activity of the targets and the active ingredients. The DAVID was used to analyze the gene function and signal pathway. A model was built with Cytoscape. The core genes were obtained by PPI network. We screened the 4 main medicinal ingredients of PTH to obtain 16 active ingredient, 190 potential targets, and 6 core genes. We found that active small molecules exert anticancer effects by multiple pathways. The core genes were involved in multiple biological processes. We also found that eight chemical components play a greater role in inhibiting liver cancer. PTH achieves the effect of inhibiting liver cancer through the synergistic effect of multiple components, multiple targets, and multiple pathways. This study provides a potential scientific basis for further elucidating the molecular mechanism of action of PTH against liver cancer.

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miR-296-5p suppresses stem cell potency of hepatocellular carcinoma cells via regulating Brg1/Sall4 axis

Cited by 30 publications

References 44 publications

Functional roles of non-coding RNAs regulated by thyroid hormones in liver cancer

Functional roles of non-coding RNAs regulated by thyroid hormones in liver cancer

MiRNA-mediated EMT and CSCs in cancer chemoresistance

Uncovering the Mechanism of the Effects of Pien-Tze-Huang on Liver Cancer Using Network Pharmacology and Molecular Docking

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