2021
DOI: 10.1186/s40164-021-00206-5
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MiRNA-mediated EMT and CSCs in cancer chemoresistance

Abstract: Cancer stem cells (CSCs) are a small group of cancer cells, which contribute to tumorigenesis and cancer progression. Cancer cells undergoing epithelial-to-mesenchymal transition (EMT) acquire the chemoresistant ability, which is regarded as an important feature of CSCs. Thus, there emerges an opinion that the generation of CSCs is considered to be driven by EMT. In this complex process, microRNAs (miRNAs) are found to play a key role. In order to overcome the drug resistance, inhibiting EMT as well as CSCs ph… Show more

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Cited by 54 publications
(39 citation statements)
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References 129 publications
(130 reference statements)
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“…The manipulation of miRNA expression may represent a means of inhibiting EMT-mediated resistance to chemotherapy agents. Compared to the permanent impact of mutations and deletions, the expression of miRNAs and EMT-ATFs can be dynamically regulated, making them attractive targets for personalized oncological treatment [ 195 ]. As chemotherapy usually targets a single oncogenic signal and is therefore inevitably associated with the development of resistance or recurrence, multiple simultaneous approaches to various pathways and cancer cell traits may yield better results [ 196 ].…”
Section: Discussionmentioning
confidence: 99%
“…The manipulation of miRNA expression may represent a means of inhibiting EMT-mediated resistance to chemotherapy agents. Compared to the permanent impact of mutations and deletions, the expression of miRNAs and EMT-ATFs can be dynamically regulated, making them attractive targets for personalized oncological treatment [ 195 ]. As chemotherapy usually targets a single oncogenic signal and is therefore inevitably associated with the development of resistance or recurrence, multiple simultaneous approaches to various pathways and cancer cell traits may yield better results [ 196 ].…”
Section: Discussionmentioning
confidence: 99%
“…109,113 An increasing number of miRNAs have been shown to mediate proliferation, EMT, and cancer stemness through diverse targets. 104 For example, Le et al 114 demonstrated that MVs derived from murine and human breast cancer cells could be used to deliver miR-200 to nonmetastatic cancer cells, promoting mesenchymal-to-epithelial transition. Tumors expressing miR-200 and MVs from murine cancer and human xenograft models facilitated metastasis of poorly metastatic cells at both nearby and distant sites, and endowed these cells with the ability to colonize distant tissues in a miR-200-dependent manner.…”
Section: Dovepressmentioning
confidence: 99%
“…Non-coding RNAs (ncRNAs), including miRNAs exert critical function in the regulation of cellular processes that are involved in the EMT, as a result, some miRNAs impact cancer stemness and drug resistance. Therefore, understanding the relationship between EMT and miRNAs is beneficial to both basic research and clinical treatment [ 81 , 82 , 83 , 84 ]. The impact of VPA on miR-34a [ 85 ], miR-520h [ 81 ], and their target gene HDAC1 expression, as well as their involvement in the induction of apoptosis in MCF-7 and MDA-MB-231 BC cell lines, were evaluated.…”
Section: Valproic Acid and Breast Cancermentioning
confidence: 99%