miR-193a-3p regulation of chemoradiation resistance in oesophageal cancer cells via the PSEN1 gene

Fang, Meng; Qian, Liting; Lv, Lei; Ding, Bojin; Zhou, Gieping; Xu, Cheng; Niu, Sanqiang; Yu, Liang

doi:10.1016/j.gene.2015.12.060

Cited by 41 publications

(37 citation statements)

References 24 publications

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“…[29][30][31] Moreover, antagonizing miR-193a-3p expressions could raise radio-sensitivity and drug susceptibility of esophageal cancer cell lines that were tolerant to radioactive rays and chemotherapeutics. 20 Besides, up-regulating miR-193a-3p expressions within the QGY-7703 cells that were sensitive to 5-flurouracil (5-FU) would further enhance the cells' tolerance to 5-FU, whereas down-regulating miR-193a-3p expressions within SMMC-7721 cells that were tolerant to 5-FU would oppositely elevate the cells' sensitivity to 5-FU. 18 Thus, a conclusion was drawn that miR-193a-3p could promote HCC cells' tolerance to 5-FU, and accelerate their multiplication, 18 yet Liu et al 17 documented that miR-193a-3p was a tumor-suppressive miRNA for liver cancer.…”

Section: Discussionmentioning

confidence: 99%

“…Nevertheless, whether lncRNA H19 interacted with miR‐193a‐3p to modify the radio‐resistance of HCC remained unclear. In addition, presenilin‐1 (PSEN1), a primary component of the γ‐secretase complex, was demonstrated to be suppressed by miR‐193a‐3p, and it probably encouraged the radio‐sensitivity of esophageal cancer cells …”

Section: Introductionmentioning

confidence: 99%

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The LncRNA H19/miR‐193a‐3p axis modifies the radio‐resistance and chemotherapeutic tolerance of hepatocellular carcinoma cells by targeting PSEN1

Liu

et al. 2018

J of Cellular Biochemistry

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This study was designated to verify if the lncRNA H19/miR-193a-3p axis would play a regulatory role in the radio-/chemo-resistances of HCC cells through targeting PSEN1. Within the study, five human HCC cell lines were prepared, including Bel-7402, HepG2, Hep3b, QGY-7703, and SMMC-7721. Moreover, docetaxel (DT), paclitaxel (Pt), vinorelbine (Vb), and 5-fluorouracil (5-Fu) were managed as the chemo-therapeutics, and single-dose X-rays were performed as radio-therapies. Besides, lncRNA H19 and miR-193a-3p were detected by qRT-PCR and Western blot were implemented to quantify the expressional levels of PSEN1, Ku80, γ-H2AX, and RAD51. Luciferase reporter gene assay was advanced to verify the targeted relationship between lncRNA H19 and miR-193a-3p. As a consequence, QGY-7703 and Bel-7402 were, respectively, the most radiation-sensitive and radiation-proof cell lines, and Bel-7402 was associated with the highest resistances to DT, Pt, Vb, and 5-FU. The restrained lncRNA H19 and over-expressed miR-193a-3p expressions tended to significantly elevate the survival rate and proliferation of Bel-7402 cells, when they were exposed to radiation and subject to chemo-therapies. The lncRNA H19 was also found to directly target miR-193a-3p in inducing the HCC development. PSEN1 appeared to be subject to the modification of lncRNA H19 and miR-193a-3p in its acting on the survival rates and proliferative abilities of HCC cells. The lncRNA H19/miR-193a-3p/PSEN1 axis could be regarded as the treatment targets for HCC, so as to further improve the treatment efficacy of chemo- and radio-therapies for HCC.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The LncRNA H19/miR‐193a‐3p axis modifies the radio‐resistance and chemotherapeutic tolerance of hepatocellular carcinoma cells by targeting PSEN1

Liu

et al. 2018

J of Cellular Biochemistry

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“…Accordingly, it was stated that miR‐193a‐3p decreased the expression of some targets including SRSF2, PLAU, HIC2 (L. Lv et al, ), LOXL4 (H. Deng et al, ), ING‐5 (Y. Li et al, ), HOXC9 (L. Lv et al, ), and PSEN‐1 (H. Deng et al, ) in chemoresistant bladder cancer cells. More particularly, PSEN‐1 has been mentioned as also relevant in chemo‐ and radioresistant esophageal cancer cells (Meng et al, ). Moreover, it was considered that repressed activity of miR‐193a‐3p caused by the sponge impact of Linc00152 which usually overexpressed in colon cancer tissues was associated with oxaliplatin resistance in colon cancer cells.…”

Section: Potential Roles Of Mir‐193 Family In Cancer Diagnosis Prognmentioning

confidence: 99%

miR‐193: A new weapon against cancer

Khordadmehr

Shahbazi

Sadreddini

et al. 2019

Journal Cellular Physiology

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microRNAs (miRNAs) are known as a large group of short noncoding RNAs, which structurally consist of 19–22 nucleotides in length and functionally act as one of the main regulators of gene expression in important biological and physiological contexts like cell growth, apoptosis, proliferation, differentiation, movement (cell motility), and angiogenesis as well as disease formation and progression importantly in cancer cell invasion, migration, and metastasis. Among these notable tiny molecules, many studies recently presented the important role of the miR‐193 family comprising miR‐193a‐3p, miR‐193a‐5p, miR‐193b‐3p, and miR‐193b‐5p in health and disease biological processes by interaction with special targeting and signaling, which mainly contribute as a tumor suppressor. Therefore, in the present paper, we review the functional role of this miRNA family in both health and disease conditions focusing on various tumor developments, diagnoses, prognoses, and treatment.

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“…The same ncRNA could have a role in the sensibilization to different drugs: e.g., miR-506-3p, which is up-regulated in ovarian cancer, has an important function in sensitizing cancer cells to both olaparib and cisplatin (294). Another interesting example is miR-193a-3p that can contribute to the inhibition of chemoradiation and of cisplatin resistance through PSEN1 and p73, respectively in esophageal tumor (295) and osteosarcoma (296). These findings confirmed an oncosuppressor activity for miR-193a-3p (297).…”

Section: Drugs/non-coding Rnas Subnetworkmentioning

confidence: 99%

The Network of Non-coding RNAs in Cancer Drug Resistance

et al. 2018

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Non-coding RNAs (ncRNAs) have been implicated in most cellular functions. The disruption of their function through somatic mutations, genomic imprinting, transcriptional and post-transcriptional regulation, plays an ever-increasing role in cancer development. ncRNAs, including notorious microRNAs, have been thus proposed to function as tumor suppressors or oncogenes, often in a context-dependent fashion. In parallel, ncRNAs with altered expression in cancer have been reported to exert a key role in determining drug sensitivity or restoring drug responsiveness in resistant cells. Acquisition of resistance to anti-cancer drugs is a major hindrance to effective chemotherapy and is one of the most important causes of relapse and mortality in cancer patients. For these reasons, non-coding RNAs have become recent focuses as prognostic agents and modifiers of chemo-sensitivity. This review starts with a brief outline of the role of most studied non-coding RNAs in cancer and then highlights the modulation of cancer drug resistance via known ncRNAs based mechanisms. We identified from literature 388 ncRNA-drugs interactions and analyzed them using an unsupervised approach. Essentially, we performed a network analysis of the non-coding RNAs with direct relations with cancer drugs. Within such a machine-learning framework we detected the most representative ncRNAs-drug associations and groups. We finally discussed the higher integration of the drug-ncRNA clusters with the goal of disentangling effectors from downstream effects and further clarify the involvement of ncRNAs in the cellular mechanisms underlying resistance to cancer treatments.

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miR-193a-3p regulation of chemoradiation resistance in oesophageal cancer cells via the PSEN1 gene

Cited by 41 publications

References 24 publications

The LncRNA H19/miR‐193a‐3p axis modifies the radio‐resistance and chemotherapeutic tolerance of hepatocellular carcinoma cells by targeting PSEN1

The LncRNA H19/miR‐193a‐3p axis modifies the radio‐resistance and chemotherapeutic tolerance of hepatocellular carcinoma cells by targeting PSEN1

miR‐193: A new weapon against cancer

The Network of Non-coding RNAs in Cancer Drug Resistance

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