MiR-181a promotes cell proliferation and migration through targeting KLF15 in papillary thyroid cancer

Sun, Chongqi; Liu, B J; Su, Yuehui; Shi, Guangwen; Wang, Y; F, J

doi:10.1007/s12094-021-02670-1

Cited by 9 publications

(6 citation statements)

References 40 publications

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“…As a member of the KLF family proteins, KLF15 is expressed in multiple tissues, especially in the kidney, and is also known as kidney-enriched KLF [43] . More and more studies show that KLF15 plays an anti-tumor role in different cancers [ 44 , 45 ]. In LUAD, overexpression of KLF15 can arrest cell cycle at the G0/G1 phase and inhibit LUAD cell proliferation by upregulating CDKN1A/p21 and CDKN2A/p15 [32] .…”

Section: Discussionmentioning

confidence: 99%

Circular RNA circFBXO7 attenuates non-small cell lung cancer tumorigenesis by sponging miR-296-3p to facilitate KLF15-mediated transcriptional activation of CDKN1A

Wang¹,

Ye²,

Xiang³

et al. 2023

Translational Oncology

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Section: Discussionmentioning

confidence: 99%

Circular RNA circFBXO7 attenuates non-small cell lung cancer tumorigenesis by sponging miR-296-3p to facilitate KLF15-mediated transcriptional activation of CDKN1A

Wang¹,

Ye²,

Xiang³

et al. 2023

Translational Oncology

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“…Other reports further validated that miR-181a-5p promotes metastasis of PTC. MiR-181a-5p promotes cell proliferation, invasion and EMT to aggravate PCT metastasis, while its downstream target KLF15 and suppressor of cytokine signaling 4 can counteract these effects ( 108 , 109 ). In addition, miR-181a-5p reduces the efficacy of radioactive iodine treatment by suppressing sodium iodide symporter (NIS), which is a potent iodine transporter.…”

Section: Mir-181a-5p In Different Types Of Cancermentioning

confidence: 99%

Role of miR‑181a‑5p in cancer (Review)

Shen

Zhao

et al. 2023

Int J Oncol

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MicroRNAs (miRNAs) are non-coding RNAs (ncRNAs) that can post-transcriptionally suppress targeted genes. Dysregulated miRNAs are associated with a variety of diseases. MiR-181a-5p is a conserved miRNA with the ability to regulate pathological processes, such as angiogenesis, inflammatory response and obesity. Numerous studies have demonstrated that miR-181a-5p exerts regulatory influence on cancer development and progression, acting as an oncomiR or tumor inhibitor in various cancer types by impacting multiple hallmarks of tumor. Generally, miR-181a-5p binds to target RNA sequences with partial complementarity, resulting in suppression of the targeted genes of miR-181a-5p. However, the precise role of miR-181a-5p in cancer remains incompletely understood. The present review aims to provide a comprehensive summary of recent research on miR-181a-5p, focusing on its involvement in different types of cancer and its potential as a diagnostic and prognostic biomarker, as well as its function in chemoresistance.

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“…However, in GC, it has a dual role, tumor-suppressive [ 102 ] and oncogenic [ 103 ]. It has been well established that miR-181a regulates cellular differentiation [ 104 ] and also cell proliferation, invasion, and migration in lung cancer [ 105 ], papillary thyroid cancer [ 106 ], and ovarian cancer [ 107 ].…”

Section: Diverse Mirnas Affecting Sacc Progressionmentioning

confidence: 99%