Circular RNA circFBXO7 attenuates non-small cell lung cancer tumorigenesis by sponging miR-296-3p to facilitate KLF15-mediated transcriptional activation of CDKN1A

Wang, Zi-Hao; Ye, Linlin; Xiang, Xuan; Wei, Xiao-Shan; Niu, Yulan; Peng, Wen-Bei; Zhang, Siyu; Zhang, Pei; Xue, Qianqian; Wang, Hao-Lei; Du, Yuchen; Liu, Yao; Ai, Jia-Qi; Zhou, Qiong

doi:10.1016/j.tranon.2023.101635

Cited by 7 publications

(1 citation statement)

References 46 publications

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“…Employing a less complicated approach, circFBXO7 sequesters miR-296-3p, leading to the expression of KLF15. Acting as a transcription factor, KLF15 translocates to the nucleus and binds to p21 promotor to initiate its transcription [ 170 ]. Similarly, circKIF20B sponges miR-615-3p to upregulate myocyte enhancer factor 2A (MEF2A), which later suppresses CDK4 expression [ 210 ].…”

Section: Circrna and Cell Cycle Regulators In Cancermentioning

confidence: 99%

Circular RNAs in Cell Cycle Regulation of Cancers

Thamjamrassri,

Ariyachet

2024

IJMS

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Cancer has been one of the most problematic health issues globally. Typically, all cancers share a common characteristic or cancer hallmark, such as sustaining cell proliferation, evading growth suppressors, and enabling replicative immortality. Indeed, cell cycle regulation in cancer is often found to be dysregulated, leading to an increase in aggressiveness. These dysregulations are partly due to the aberrant cellular signaling pathway. In recent years, circular RNAs (circRNAs) have been widely studied and classified as one of the regulators in various cancers. Numerous studies have reported that circRNAs antagonize or promote cancer progression through the modulation of cell cycle regulators or their associated signaling pathways, directly or indirectly. Mostly, circRNAs are known to act as microRNA (miRNA) sponges. However, they also hold additional mechanisms for regulating cellular activity, including protein binding, RNA-binding protein (RBP) recruitment, and protein translation. This review will discuss the current knowledge of how circRNAs regulate cell cycle-related proteins through the abovementioned mechanisms in different cancers.

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Section: Circrna and Cell Cycle Regulators In Cancermentioning

confidence: 99%