Role of miR‑181a‑5p in cancer (Review)

Li, Junxin; Shen, Jing; Zhao, Yueshui; Du, Fukuan; Li, Mingxing; Chen, Yu; Wang, Shurong; Xiao, Zhangang; Wu, Zhigui

doi:10.3892/ijo.2023.5556

Cited by 4 publications

(1 citation statement)

References 177 publications

(202 reference statements)

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“…It is important to note that the expression of miR-181a-5p is specific to certain tissues and can simultaneously target multiple genes, potentially playing dual roles. The function of miR-181a-5p is not reliant on a specific target but rather on the collective impact of its targets, which may encompass both tumor suppressor genes and oncogenes [12,13] . As controversy about the miR-181a role exists, this study was designed to explore the expression level of hsa-miR-181a-5p in the sera of Egyptian CRC patients and evaluate its clinical utility.…”

Section: Introductionmentioning

confidence: 99%

Clinical utility of hsa-miR-181a-5p expression level in Egyptian colorectal cancer patients

El-Korany,

Zahran,

Alm El-Din

et al. 2024

Egyptian Journal of Pure and Applied Science

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Background: Colorectal cancer (CRC) is considered one of the most aggressive malignancies worldwide, with high mortality and morbidity rates because of its asymptomatic nature at the early stages. Further, CRC is affected by ethnicity and environmental factors. MicroRNAs (miRNAs) dysregulation has a high impact on CRC development and progression, thus this study was conducted to explore hsa-miR-181a-5p expression level in the sera of Egyptian CRC patients and assess its clinical utility. Methods: Relative hsa-miR-181a-5p expression level was determined using quantitative real-time PCR in 192 specimens collected from 160 CRC patients and 32 healthy subjects. Results: Hsa-miR-181a-5p relative expression was significantly up-regulated in CRC patients compared to controls and was found to be associated with increased susceptibility to CRC. Moreover, the expression level of hsa-miR-181a-5p had a powerful diagnostic performance to detect CRC, although it is still inferior to that of carcinoembryonic antigen (CEA) and cancer antigen 19.9 (CA 19.9). Conclusion: Over-expressed hsa-miR-181a-5p may contribute to the pathogenesis of CRC, and it seems to be a valuable diagnostic biomarker to discriminate between CRC patients and healthy subjects.

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Section: Introductionmentioning

confidence: 99%

Clinical utility of hsa-miR-181a-5p expression level in Egyptian colorectal cancer patients

El-Korany,

Zahran,

Alm El-Din

et al. 2024

Egyptian Journal of Pure and Applied Science

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Prognostic values and immune infiltration of KLF15, AQP7, AGPAT9 in glioma and glioblastoma

Olajuyin,

Nwachukwu,

Olajuyin

et al. 2024

Futur J Pharm Sci

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Backgrounds The overall survival of patients with lower-grade gliomas and glioblastoma varies greatly. No reliable or existing procedures can accurately forecast survival and prognostic biomarkers for early diagnosis in glioma and glioblastoma. However, investigations are progressing in immunotherapy, tumor purity, and tumor microenvironment which may be therapeutic targets for glioma and glioblastoma. Results This study indicated the possible prognostic signatures that can be used to identify immune-related prognostic biomarkers in the prediction of the survival of low-grade glioma (LGG) patients which may be a possible therapeutic target. In addition, the Kaplan–Meier plot, ESTIMATE algorithm, and TIMER 2.0 analysis indicated that Krüppel-like factor 15 (KLF15) p = 0.030, Aquaporin 7 (AQP7) p = 0.001, and Human 1-acylglycerol-3-phosphate O-acyltransferase 9 (AGPAT9) p = 0.005 are significantly associated in glioma. Hence, they may be possible prognostic biomarkers in glioma. Meanwhile, in the glioblastoma, only KLF15 has a significant association with glioblastoma (p = 0.025). Stromal and immune scores of gliomas were determined from transcriptomic profiles of LGG cohort from TCGA (The Cancer Genome Atlas) using the ESTIMATE (Estimation of Stromal and Immune cells in Malignant Tumours using Expression data algorithm). The immune infiltration of the KLF15, AQP7, and AGPAT9 for low-grade glioma and glioblastoma was determined using TIMER immune 2.0 which indicates correlation with tumor purity for KLF15, AQP7, and AGPAT9, but only KLF15 and AGPAT9 are significantly associated in both glioma and glioblastoma, respectively. Conclusions These results highlight the significance of microenvironment monitoring, analysis of glioma and glioblastoma prognosis, and targeted immunotherapy. To our knowledge, this is the first time to investigate an analysis that revealed that KLF15, AQP7, and AGPAT9 may be important prognostic biomarkers for patients with glioma and KLF15 for patients with glioblastoma. Meanwhile, KLF15 and AGPAT9 are significantly associated in both glioma and glioblastoma, respectively, for tumor purity.

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Downregulation of Serum miR-133b and miR-206 Associate with Clinical Outcomes of Progression as Monitoring Biomarkers for Metastasis Colorectal Cancer Patients

Wanram,

Klaewkla,

Pinyosri

2024

MIRNA

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Background: Colorectal cancer (CRC) is the third most common cancer in the world. Non-coding RNAs or microRNAs (miRNAs; miRs) biomarkers can play a role in cancer carcin-ogenesis and progression. Specific KRAS and EGFR mutation are associated with CRC develop-ment playing a role in controlling the cellular process as epigenetic events. Circulating serum miRs can serve for early diagnosis, monitoring, and prognosis of CRC as biomarkers but it is still unclear, clinically. Objective: To determine potential biomarkers of circulating serum miR-133b and miR-206 in CRC patients Methods: Bioinformatic prediction of microRNA was screened followed by TargetScanHu-man7.2, miRTar2GO, miRDB, MiRanda, and DIANA-microT-CDS. Forty-four CRC serum (19 locally advanced, 23 distant advanced CRC) and 12 normal serum samples were subsequently extracted for RNA isolation, cDNA synthesis, and miR validation. The candidate circulating se-rum miR-133b and miR-206 were validated resulting in a relative expression via quantitative RT-PCR. Relative expression was normalized to the spike-internal control and compared to normal samples as 1 using the 2-ΔΔCt method in principle. Results: Our results represented 9 miRs of miR-206, miR-155-5p, miR-143-3p, miR-193a-3p, miR-30a-5p, miR-30d-5p, miR-30e-5p, miR-543, miR-877-5p relate to KRAS-specific miRs, whereas, 9 miRs of miR-133b, miR-302a-3p, miR-302b-3p, miR-302d-3p, miR-302e, miR-520a-3p, miR-520b, miR-520c-3p and miR-7-5p relevance to EGFR-specific miRs by using the bioin-formatic prediction tools. Our results showed a decreased expression level of circulating serum miR-133b as well as miR-206 associating with CRC patients (local and advanced metastasis) when compared to normal (P < 0.05), significantly. Conclusion: The circulating serum miR-133b and miR-206 can serve as significant biomarkers for monitoring the clinical outcome of progression with metastatic CRC patients. Increased drug-responsive CRC patients associated with crucial molecular intervention should be further ex-plored, clinically.

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Role of miR‑181a‑5p in cancer (Review)

Cited by 4 publications

References 177 publications

Clinical utility of hsa-miR-181a-5p expression level in Egyptian colorectal cancer patients

Clinical utility of hsa-miR-181a-5p expression level in Egyptian colorectal cancer patients

Prognostic values and immune infiltration of KLF15, AQP7, AGPAT9 in glioma and glioblastoma

Downregulation of Serum miR-133b and miR-206 Associate with Clinical Outcomes of Progression as Monitoring Biomarkers for Metastasis Colorectal Cancer Patients

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