Abstract:Background: MicroRNAs play important roles in dendritic cell (DCs)-mediated immunity, but their specific functions in lung cancer remain unclear.Objective: To investigate miR-124-3p regulation of DC-mediated immune response via CYLD/4-1BBL pathway, and the inhibitory effect of miR-124-3p on lung cancer.Methods: DCs were cultured and amplified in vitro, and then transfected with miR-124-3p mimic, miR-124-3P inhibitor, or siRNA CYLD. Double luciferase reporter genes were used to detect the target relationship be… Show more
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