MIP-based sensor platforms for the detection of histamine in the nano- and micromolar range in aqueous media

Horemans, Frederik; Alenus, Jan; Bongaers, Evi; Weustenraed, Ans; Thoelen, Ronald; Duchateau, Jan; Lutsen, Laurence; Vanderzande, Dirk; Wagner, Patrick; Cleij, Thomas J.

doi:10.1016/j.snb.2010.05.003

Cited by 77 publications

(77 citation statements)

References 36 publications

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“…However, it should be considered that this read-out technique can also be employed for other targets that are of higher interest for biomedical research, for instance histamine and serotonin. We will demonstrate that optimization of the PID parameters is a key element for future measurements in biological samples [26,27]. Summarizing, the HTM method enables fast and low-cost measurements and optimizing the sensor performance is an important step for real analytical applications.…”

Section: Introductionmentioning

confidence: 99%

Optimizing the Thermal Read-Out Technique for MIP-Based Biomimetic Sensors: Towards Nanomolar Detection Limits

Geerets

Peeters

Grinsven

et al. 2013

Sensors

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Abstract:In previous work, the novel heat-transfer method (HTM) for the detection of small molecules with Molecularly Imprinted Polymers (MIP)-type receptors was presented. In this study we focus on optimization of this sensor performance, with as final aim to lower the detection limit by reducing the noise level. It was determined that the noise originates foremost from the power supply, which can be controlled by varying the PID parameters. Therefore, the effect of the individual parameters was evaluated by tuning P, I and D separately at a temperature of 37 °C, giving a first indication of the optimal configuration. Next, a temperature profile was programmed and the standard deviation of the heat-transfer resistance over the entire regime was studied for a set of parameters. The optimal configuration, P1-I6-D0, reduced the noise level with nearly a factor of three compared to the original parameters of P10-I5-D0. With the optimized settings, the detection of L-nicotine in buffer solutions was studied and the detection limit improved significantly from 100 nM to 35 nM. Summarizing, optimization of the PID parameters and thereby improving the detection limit is a key parameter for first applications of the HTM-method for MIP receptors in analytical research.

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Section: Introductionmentioning

confidence: 99%

Optimizing the Thermal Read-Out Technique for MIP-Based Biomimetic Sensors: Towards Nanomolar Detection Limits

Geerets

Peeters

Grinsven

et al. 2013

Sensors

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“…The functional monomer MAA [43] (the pKa 6.5), which was used by Bongaers et al [42], Horemans et al [40], and Trikka et al [35], is a deprotonated form (COO − ) at neutral pH, which binds to histamine. The MIP synthesized from MAA is suitable for rebinding of histamine at pH 7.4 [34,35].…”

Section: Resultsmentioning

confidence: 99%

“…In this direction, MIP-based sensors have attracted much interest due to easy preparation, good stability, and robustness. In the literature, histamine-imprinted polymers and MIP-based sensors have already been reported for histamine recognition [35,36,37] in surface enhanced Raman spectroscopy (SER) [38], thermal [39], quartz crystal microbalance (QCM) [40], amperometric [41], and impedimetric [34,42] sensors.…”

Section: Introductionmentioning

confidence: 99%

Ultratrace Detection of Histamine Using a Molecularly-Imprinted Polymer-Based Voltammetric Sensor

Akhoundian

Rüter

Shinde

2017

Sensors

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Rapid and cost-effective analysis of histamine, in food, environmental, and diagnostics research has been of interest recently. However, for certain applications, the already-existing biological receptor-based sensing methods have usage limits in terms of stability and costs. As a result, robust and cost-effective imprinted polymeric receptors can be the best alternative. In the present work, molecularly-imprinted polymers (MIPs) for histamine were synthesized using methacrylic acid in chloroform and acetonitrile as two different porogens. The binding affinity of the MIPs with histamine was evaluated in aqueous media. MIPs synthesized in chloroform displayed better imprinting properties for histamine. We demonstrate here histamine MIPs incorporated into a carbon paste (CP) electrode as a MIP-CP electrode sensor platforms for detection of histamine. This simple sensor format allows accurate determination of histamine in the sub-nanomolar range using an electrochemical method. The sensor exhibited two distinct linear response ranges of 1 × 10−10–7 × 10−9 M and 7 × 10−9–4 × 10−7 M. The detection limit of the sensor was calculated equal to 7.4 × 10−11 M. The specificity of the proposed electrode for histamine is demonstrated by using the analogous molecules and other neurotransmitters such as serotonin, dopamine, etc. The MIP sensor was investigated with success on spiked serum samples. The easy preparation, simple procedure, and low production cost make the MIP sensor attractive for selective and sensitive detection of analytes, even in less-equipped laboratories with minimal training.

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“…Binding sites with molecular recognition properties are formed after removing template molecules from the polymer, leaving behind cavities complementary in size and shape to the template for the subsequent rebinding process. Nowadays, MIPs are of growing interest for their potential applications as artificial enzymes [33], advanced materials for solid-phase extraction [34], thin coatings for sensor devices [35] and for determination of drugs [36,37], small analytes [38], peptides [39], proteins [40][41][42][43], and cancer biomarkers and viruses [44]. So, nanoparticles were used for selectivity enhancement to improve the cavity accessibility in MIP layer on the electrode surface.…”

Section: Introductionmentioning

confidence: 99%

Fabrication of electrochemical sensor based on molecularly imprinted polymer and nanoparticles for determination trace amounts of morphine

Rezaei

Foroughi-Dehnavi

Ensafi

2015

Ionics

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A simple and rapid electrochemical method developed for the detection of trace amounts of morphine (MO) at the surface of modified pencil graphite electrode (PGE) with multiwall carbon nanotubes (MWCNTs), molecularly imprinted polymer (MIP), and gold nanoparticles (AuNPs).Various types of electrochemical methods containing cyclic voltammetry (CV), square wave voltammetry (SWV), and electrochemical impedance spectroscopy (EIS) were employed to probe the characteristics of the constructed electrode toward morphine. After optimization of several effective parameters, the calibration curve by SWV was linear in two linear domains, over the range of 0.008 to 5 μmol L −1 vs. Ag/AgCl, and the detection limit was 2.9 nM. The relative standard deviation (RSD) for six replicate determinations of 0.05 μmol L −1 MO was found to be 2.57 % (S/N = 3). Finally, the ability of the electrochemical sensor was successfully applied for MO determination in real samples such as human urine and plasma.

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MIP-based sensor platforms for the detection of histamine in the nano- and micromolar range in aqueous media

Cited by 77 publications

References 36 publications

Optimizing the Thermal Read-Out Technique for MIP-Based Biomimetic Sensors: Towards Nanomolar Detection Limits

Optimizing the Thermal Read-Out Technique for MIP-Based Biomimetic Sensors: Towards Nanomolar Detection Limits

Ultratrace Detection of Histamine Using a Molecularly-Imprinted Polymer-Based Voltammetric Sensor

Fabrication of electrochemical sensor based on molecularly imprinted polymer and nanoparticles for determination trace amounts of morphine

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